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BioActivity Data for Compound pirarubicin (CID 11296583)

BioActivity Outcomes:
Active(50)
 
 
Inactive(36)
 
 
Inconclusive(35)
 
 
Top Targets:
NR LBD PPAR(8)
 
 
 
 
NR LBD AR(7)
 
 
 
 
NR LBD ER(7)
 
 
 
NR LBD Fxr(4)
 
 
 
NR LBD VDR(4)
 
 
BioAssay Types:
Confirmatory(87)
 
 
 
 
Summary(24)
 
 
 
 
Screening(10)
 
 
 
BioActivity Types:
Potency(85)
 
 
 
 
IC50(17)
 
 
 
AC50(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 121    Data Row: 121   Total Pages: 7   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID170465822]
IC50 0.0063VEGF stimulated ADSC/ECFC co-culture CD31-stained tube area decrease-IC50 [AID1117337, Type: confirmatory]
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2
[SID144206155]
Potency-Replicate_1 0.0298qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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3
[SID170465822]
IC50 0.05143Decreased HeLa cell count-IC50 [AID1117347, Type: confirmatory]
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4
[SID170465822]
IC50 0.0795Increased HeLa cells with 2N DNA content-IC50 [AID1117349, Type: confirmatory]
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5
[SID170465822]
IC50 0.08063Increased HeLa cells with 4N DNA content-IC50 [AID1117351, Type: confirmatory]
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6
[SID144206155]
Potency-Replicate_1 0.1883qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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7
[SID144206155]
Potency 0.1884qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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8
[SID144206155]
Potency-Replicate_1 0.2371qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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9
[SID144206155]
Potency 0.335qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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10
[SID144206155]
Ratio Potency (uM) 0.604487qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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11
[SID144206155]
Potency-Replicate_1 0.6987qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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12
[SID144206155]
Potency-Replicate_1 0.8413qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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13
[SID170465822]
IC50 0.9107HCT116 viability from Cell TiterGlo-IC50 [AID1117332, Type: confirmatory]
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14
[SID170465822]
IC50 0.99489VEGF stimulated ADSC/ECFC co-culture nuclear area decrease (viability)-IC50 [AID1117324, Type: confirmatory]
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15
[SID170465822]
IC50 1.00957RKO viability from Cell TiterGlo-IC50 [AID1117322, Type: confirmatory]
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16
[SID144206155]
Potency 1.1175qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID720533, Type: confirmatory]
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17
[SID144206155]
Potency 1.2538qHTS for Inhibitors of binding or entry into cells for Marburg Virus [AID720532, Type: confirmatory]gene 4 small orf - Marburg virus [Marburg marburgvirus] [gi:420597]
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18
[SID170465822]
IC50 1.27514GSK3B-pretreated HCT116 viability from Cell TiterGlo-IC50 [AID1117339, Type: confirmatory]
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19
[SID144206155]
Potency-Replicate_1 1.6785qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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20
[SID170465822]
IC50 1.74634Increased HeLa cells in S-phase-IC50 [AID1117348, Type: confirmatory]
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