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BioActivity Data for Compound 3-benzenesulfonyl-8-piperazin-1-ylquinoline (CID 11256720)

BioActivity Outcomes:
Active(5)
 
 
Unspecified(5)
 
 
BioAssay Types:
Literature(10)
 
 
 
BioAssay Categories:
In vivo(4)
 
 
Biochemical(5)
 
 
ADME(5)
 
 
Cell-based(3)
 
 
BioActivity Types:
Ki(3)
 
 
IC50(1)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 10    Data Row: 10   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103756096]
Ki 0.00017Displacement of [3H]LSD from human 5-HT6 receptor expressed in human HeLa cells after 1 hr by scintillation spectroscopic analysis [AID1154620, Type: Literature]5-hydroxytryptamine receptor 6 [gi:1703010]
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2
[SID103756096]
Ki 0.000234Binding affinity to 5HT6 receptor [AID482331, Type: Literature]
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3
[SID103756096]
Ki 0.01Displacement of [3H]LSD from human 5HT6 receptor expressed in HeLa cells [AID599941, Type: Literature]5-hydroxytryptamine receptor 6 [gi:1703010]
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4
[SID103756096]
Antagonist activity at human 5-HT6 receptor expressed in CHO cells assessed as reduction in serotonin-induced cAMP accumulation after 30 mins by HTRF assay [AID1154622, Type: Literature]5-hydroxytryptamine receptor 6 [gi:1703010]
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5
[SID103756096]
IC50 Antagonist activity at 5-HT6 receptor (unknown origin) [AID763551, Type: Literature]5-hydroxytryptamine receptor 6 [gi:1703010]
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6
[SID103756096]
Half life in rat at 1 mg/kg, iv [AID647185, Type: Literature]
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7
[SID103756096]
Plasma clearance in rat at 1 mg/kg, iv [AID647186, Type: Literature]
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8
[SID103756096]
Volume of distribution in rat at 1 mg/kg, iv [AID647187, Type: Literature]
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9
[SID103756096]
Oral bioavailability in rat at 5 mg/kg at 24 hrs [AID647188, Type: Literature]
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10
[SID103756096]
Ratio of drug uptake in brain to plasma in rat at 5 mg/kg, po [AID647189, Type: Literature]
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