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ABT-737 (CID 11228183) - Compound BioActivity Data
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BioActivity Outcomes:
Active(109)
 
 
Inactive(21)
 
 
Inconclusive(2)
 
 
Unspecified(43)
 
 
Top Targets:
Bcl-2 like(30)
 
 
 
 
BioAssay Types:
Literature(162)
 
 
 
 
 
Confirmatory(7)
 
 
BioActivity Types:
IC50(48)
 
 
 
 
Ki(36)
 
 
 
EC50(25)
 
 
 
 
Potency(7)
 
 
Kd(4)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 175    Data Row: 175   Total Pages: 4   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103505845]
IC50 0.0003Inhibition of GST-tagged Bcl-xl/FITC-conjugated PUMA interaction by fluorescence polarisation assay [AID515601, Type: Literature]
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2
[SID103505845]
Kd 0.00037Binding affinity to Bcl-Xl [AID587007, Type: Literature]
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3
[SID103505845]
Ki 0.0005Binding affinity to Bcl-xL [AID654462, Type: Literature]
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4
[SID103505845]
Kd 0.0006Binding affinity to Bcl-2 (unknown origin) by surface plasmon resonance analysis [AID727592, Type: other]Apoptosis regulator Bcl-2 [gi:231632]
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5
[SID103505845]
Ki 0.0006Binding affinity to Bcl-XL assessed as inhibition of Bcl-XL-BAD derived peptide interaction [AID318565, Type: Literature]
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6
[SID103505845]
Ki 0.001Displacement of fluorescein labeled BAD peptide from Bcl-XL by fluorescence polarization assay [AID389260, Type: Literature]
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7
[SID103505845]
Ki 0.001Displacement of fluorescein labeled Bax peptide from Bcl2 by fluorescence polarization assay [AID389261, Type: Literature]
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8
[SID103505845]
Ki 0.001Displacement of BODIPY-Bak conjugated peptide from GST-tagged human Bcl-2-like protein 1 G196A mutant expressed in Escherichia coli BL21 cells at 10 uM after 3 hrs by fluorescence polarization competition assay [AID628488, Type: Literature]
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9
[SID103505845]
Ki 0.001Binding affinity to Bcl-xL by competitive fluorescence polarization assay [AID640027, Type: Literature]
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10
[SID103505845]
Ki 0.001Binding affinity to Bcl-2 by competitive fluorescence polarization assay [AID640028, Type: Literature]
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11
[SID103505845]
IC50 0.001Inhibition of Bcl-XL [AID671072, Type: Literature]
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12
[SID103505845]
IC50 0.001Inhibition of Bcl2 [AID671073, Type: Literature]
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13
[SID103505845]
IC50 0.001Inhibition of Bcl-w [AID671074, Type: Literature]
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14
[SID103505845]
Ki 0.001Binding affinity to Bcl-2 [AID654461, Type: Literature]
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15
[SID103505845]
Ki 0.001Binding affinity to Bcl-w [AID701526, Type: Literature]
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16
[SID103505845]
Ki 0.001Binding affinity to Bcl2 [AID701527, Type: Literature]
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17
[SID103505845]
Ki 0.001Binding affinity to Bcl-XL [AID701528, Type: Literature]
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18
[SID103505845]
Ki 0.001Binding affinity to Bcl-2 [AID710843, Type: Literature]
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19
[SID103505845]
Ki 0.001Binding affinity to Bcl-XL [AID710850, Type: Literature]
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20
[SID103505845]
Ki 0.001Binding affinity to Bcl-2 (unknown origin) fluorescence polarization assay [AID721471, Type: Literature]Apoptosis regulator Bcl-2 [gi:231632]
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21
[SID103505845]
Ki 0.001Displacement of Bax-derived peptide from Bcl2 by fluorescence polarization assay [AID277486, Type: Literature]Apoptosis regulator Bcl-2 [gi:231632]
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22
[SID103505845]
Ki 0.0014Displacement of BODIPY-Bak conjugated peptide from GST-tagged human Bcl-2-like protein 1 A93V mutant expressed in Escherichia coli BL21 cells at 10 uM after 3 hrs by fluorescence polarization competition assay [AID628396, Type: Literature]
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23
[SID103505845]
Ki 0.0015Displacement of BODIPY-Bak conjugated peptide from GST-tagged human Bcl-2-like protein 1 Y195F mutant expressed in Escherichia coli BL21 cells at 10 uM after 3 hrs by fluorescence polarization competition assay [AID628487, Type: Literature]
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24
[SID103505845]
IC50 0.002Inhibition of human N-terminal His6-tagged Bcl2 isoform 2 expressed in Escherichia coli BL21(DE3) assessed as inhibition of Fluorescein-labeled BIM binding after 1 to 2 hrs by fluorescence polarization assay [AID694151, Type: Literature]
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25
[SID103505845]
IC50 0.002Binding affinity to N-terminus 6X His-tagged human Bcl2 expressed in Escherichia coli BL21 (DE3) cells after 2 hrs by fluorescence polarization assay [AID675720, Type: Literature]Apoptosis regulator Bcl-2 [gi:231632]
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26
[SID103505845]
IC50 0.002Inhibition of GST-tagged Bcl-xl/FITC-conjugated Bim interaction by fluorescence polarisation assay [AID515600, Type: Literature]
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27
[SID103505845]
EC50 0.00203Cytotoxicity against mouse mcl-1 deficient MEF cells after 24 hrs by Cell titer glo assay in presence of 1% serum [AID587090, Type: Literature]
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28
[SID103505845]
IC50 0.003Displacement of biotinylated Bim-BH3 from GST-tagged Bcl-Xl by AlphaScreen competitive assay [AID587008, Type: Literature]
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29
[SID103505845]
Ki 0.0034Displacement of BODIPY-Bak conjugated peptide from GST-tagged human Wild type Bcl-2-like protein 1 expressed in Escherichia coli BL21 cells at 10 uM after 3 hrs by fluorescence polarization competition assay [AID628395, Type: Literature]Bcl-2-like protein 1 [gi:728955]
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30
[SID103505845]
EC50 0.0045Induction of apoptosis in human CLL cells [AID526651, Type: Literature]
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31
[SID103505845]
Ki 0.0045Displacement of BODIPY-Bak conjugated peptide from GST-tagged human Bcl-2-like protein 1 E129H mutant expressed in Escherichia coli BL21 cells at 10 uM after 3 hrs by fluorescence polarization competition assay [AID628401, Type: Literature]
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32
[SID103505845]
Ki 0.0058Displacement of BODIPY-Bak conjugated peptide from GST-tagged human Bcl-2-like protein 1 E96G mutant expressed in Escherichia coli BL21 cells at 10 uM after 3 hrs by fluorescence polarization competition assay [AID628397, Type: Literature]
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33
[SID103505845]
IC50 0.006Inhibition of human N-terminal His8-tagged Bcl-XL expressed in Escherichia coli BL21(DE3) assessed as inhibition of Fluorescein-labeled BAK binding after 1 to 2 hrs by fluorescence polarization assay [AID694152, Type: Literature]Bcl-2-like protein 1 [gi:728955]
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34
[SID103505845]
IC50 0.006Binding affinity to N-terminus 8X His-tagged human Bcl-xL expressed in Escherichia coli BL21 (DE3) cells after 2 hrs by fluorescence polarization assay [AID675721, Type: Literature]Bcl-2-like protein 1 [gi:728955]
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35
[SID103505845]
IC50 0.0061Displacement of wild type mBimBH3 from human Bcl-2 by solution competition assay [AID587010, Type: Literature]Apoptosis regulator Bcl-2 [gi:231632]
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36
[SID103505845]
EC50 0.0077Cytotoxicity against IL3-dependent mouse FL5.12 cells overexpressing human Bcl2 assessed as cell viability after 24 hrs by MTS assay in absence of serum [AID389262, Type: Literature]
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37
[SID103505845]
Ki 0.008Binding affinity to BCl2 [AID526646, Type: Literature]
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38
[SID103505845]
EC50 0.008Reversal of cytokine withdrawal protection in IL3 dependent Bcl2 overexpressing mouse FL5.12 cells in presence of bovine gelatin [AID277497, Type: Literature]Apoptosis regulator Bcl-2 [gi:231632]
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39
[SID103505845]
EC50 0.0083Inhibition of cell growth in human DoHH2 cells overexpressing Bcl2 in presence of 3% FBS [AID277489, Type: Literature]Apoptosis regulator Bcl-2 [gi:231632]
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40
[SID103505845]
EC50 0.01Inhibition of GST-tagged recombinant Bcl-XL interaction with biotinylated Bim peptide by ELISA based competitive binding assay [AID701519, Type: Literature]
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41
[SID103505845]
Ki 0.01Displacement of BODIPY-Bak conjugated peptide from GST-tagged human Bcl-2-like protein 1 A142Gdelta136T mutant expressed in Escherichia coli BL21 cells at 10 uM after 3 hrs by fluorescence polarization competition assay [AID628489, Type: Literature]
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42
[SID103505845]
IC50 0.01Inhibition of GST-tagged Bel-xl/FITC-conjugated Bak interaction by fluorescence polarisation assay [AID515598, Type: Literature]
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43
[SID103505845]
EC50 0.014Inhibition of cell growth in human RS11380 cells overexpressing Bcl2 in presence of 3% FBS [AID277491, Type: Literature]Apoptosis regulator Bcl-2 [gi:231632]
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44
[SID103505845]
IC50 0.02Inhibition of Bcl-2/biotinylated BAK (unknown origin) interaction incubated for 1 hr by surface plasmon resonance analysis [AID727591, Type: other]Apoptosis regulator Bcl-2 [gi:231632]
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45
[SID103505845]
EC50 0.02Inhibition of Bcl2-BAK interaction after 1 hr by surface plasmon resonance assay [AID683531, Type: other]
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46
[SID103505845]
Ki 0.021Displacement of BODIPY-Bak conjugated peptide from GST-tagged human Bcl-2-like protein 1 A142G mutant expressed in Escherichia coli BL21 cells at 10 uM after 3 hrs by fluorescence polarization competition assay [AID628485, Type: Literature]
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47
[SID103505845]
IC50 0.023Inhibition of GST-tagged Bcl-xl/FITC-conjugated Bax interaction by fluorescence polarisation assay [AID515597, Type: Literature]
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48
[SID103505845]
EC50 0.02999Inhibition of Bcl-XL [AID539959, Type: Literature]
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49
[SID103505845]
Ki 0.03Binding affinity to Bcl-xl [AID526645, Type: Literature]
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50
[SID103505845]
EC50 0.03Cytotoxicity against IL3-dependent mouse FL5.12 cells overexpressing human Bcl-XL assessed as cell viability after 24 hrs by MTS assay in absence of serum [AID389263, Type: Literature]
View