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ABT-737 (CID 11228183) - Compound BioActivity Data
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BioActivity Outcomes:
Active(119)
 
 
Inactive(21)
 
 
Inconclusive(2)
 
 
Unspecified(47)
 
 
Top Targets:
Bcl-2 like(36)
 
 
 
 
BioAssay Types:
Literature(182)
 
 
 
 
 
Confirmatory(7)
 
 
BioActivity Types:
IC50(54)
 
 
 
 
Ki(39)
 
 
 
EC50(29)
 
 
 
 
Potency(7)
 
 
Kd(5)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 188    Data Row: 189   Total Pages: 10   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103505845]
Kd 0.00013Binding affinity to human GST-tagged Bcl-Xl assessed as dissociation rate by surface plasmon resonance assay [AID756752, Type: Literature]Bcl-2-like protein 1 [gi:728955]
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2
[SID103505845]
IC50 0.0003Inhibition of GST-tagged Bcl-xl/FITC-conjugated PUMA interaction by fluorescence polarisation assay [AID515601, Type: Literature]
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3
[SID103505845]
Kd 0.00037Binding affinity to Bcl-Xl [AID587007, Type: Literature]
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4
[SID87557472]
Ki 0.0005Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, Crystal Structure Of Bcl-Xl In Complex With Abt-737 [gi:149244054]
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5
[SID87557472]
Ki 0.0005Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, Crystal Structure Of Bcl-Xl In Complex With Abt-737 [gi:149244054]
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6
[SID103505845]
IC50 0.0005Binding affinity to human GST-tagged Bcl-Xl by luminescence proximity assay [AID756759, Type: Literature]Bcl-2-like protein 1 [gi:728955]
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7
[SID103505845]
Ki 0.0005Binding affinity to human GST-tagged Bcl-Xl by fluorescence polarization assay [AID756765, Type: Literature]Bcl-2-like protein 1 [gi:728955]
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8
[SID103505845]
Ki 0.0005Binding affinity to Bcl-xL [AID654462, Type: Literature]
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9
[SID103505845]
Ki 0.0006Binding affinity to Bcl-XL assessed as inhibition of Bcl-XL-BAD derived peptide interaction [AID318565, Type: Literature]
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10
[SID103505845]
Kd 0.0006Binding affinity to Bcl-2 (unknown origin) by surface plasmon resonance analysis [AID727592, Type: Literature]Apoptosis regulator Bcl-2 [gi:231632]
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11
[SID103505845]
Ki 0.001Binding affinity to Bcl-2 (unknown origin) fluorescence polarization assay [AID721471, Type: Literature]Apoptosis regulator Bcl-2 [gi:231632]
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12
[SID103505845]
Ki 0.001Displacement of fluorescein labeled BAD peptide from Bcl-XL by fluorescence polarization assay [AID389260, Type: Literature]
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13
[SID103505845]
Ki 0.001Displacement of fluorescein labeled Bax peptide from Bcl2 by fluorescence polarization assay [AID389261, Type: Literature]
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14
[SID103505845]
Ki 0.001Binding affinity to Bcl-xL by competitive fluorescence polarization assay [AID640027, Type: Literature]
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15
[SID103505845]
Ki 0.001Binding affinity to Bcl-2 by competitive fluorescence polarization assay [AID640028, Type: Literature]
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16
[SID103505845]
Ki 0.001Displacement of Bax-derived peptide from Bcl2 by fluorescence polarization assay [AID277486, Type: Literature]Apoptosis regulator Bcl-2 [gi:231632]
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17
[SID103505845]
Ki 0.001Binding affinity to Bcl-2 [AID654461, Type: Literature]
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18
[SID103505845]
Ki 0.001Binding affinity to Bcl-w [AID701526, Type: Literature]
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19
[SID103505845]
Ki 0.001Binding affinity to Bcl2 [AID701527, Type: Literature]
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20
[SID103505845]
Ki 0.001Binding affinity to Bcl-XL [AID701528, Type: Literature]
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