ataluren (CID 11219835) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(10)
 
 
Inactive(84)
 
 
Inconclusive(4)
 
 
Unspecified(44)
 
 
Top Targets:
7TM GPCR Srx(3)
 
 
Firefly Luc l..(3)
 
 
7TM GPCR Srw(2)
 
 
Geminin(2)
 
 
PMP22 Claudin(2)
 
 
 
BioAssay Types:
Literature(114)
 
 
 
 
Confirmatory(21)
 
 
 
 
Screening(7)
 
 
 
BioActivity Types:
Potency(21)
 
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 81    Data Row: 142   Total Pages: 3   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85852879]
Potency 0.0072Biochemical firefly luciferase enzyme assay for NPC [AID624030, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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2
[SID85852879]
Potency 0.3013Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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3
[SID85852879]
Potency 0.7079VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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4
[SID87334013]
 Thermal Shift Assay for Inhibitors of FLuc (Firefly Luciferase, Photinus pyralis) in Absence of ATP [AID2229, Type: screening]Luciferase [Photinus pyralis] [gi:160794]
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5
[SID87334013]
 Thermal Shift Assay for Inhibitors of FLuc (Firefly Luciferase, Photinus pyralis) in Presence of ATP [AID2228, Type: screening]Luciferase [Photinus pyralis] [gi:160794]
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6
[SID103563347]
 Induction of ribosomal readthrough of dystrophin mRNA premature nonsense codons in primary muscle cell culture at 17 uM by immunocytometry [AID330976, Type: Literature]
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7
[SID103563347]
 Reduction in serum creatinine levels in orally and ip dosed mdx mouse Extensor digitorum longus muscle after 2 weeks [AID330978, Type: Literature]
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8
[SID103563347]
 Increase in level of gamma sarcoplycan in mdx mouse muscle [AID330979, Type: Literature]
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9
[SID103563347]
 Effect on production of dystrophin in mdx mouse muscle by western blotting [AID330980, Type: Literature]
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10
[SID103563347]
 Induction of readthrough of normal termination codon of beta-2 microglobulin mRNA in human pooled PBMC cells at 200 mg/kg, po by western blotting [AID331013, Type: Literature]
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11
[SID103563347]
 Decrease in AW4749 genebank mRNA level in human HEK293 cells at 5 uM after 48 hrs by microarray analysis [AID331014, Type: Literature]
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12
[SID103563347]
 Increase in AA844509 genebank mRNA level in human HEK293 cells at 5 uM after 48 hrs by microarray analysis [AID331015, Type: Literature]
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13
[SID103563347]
 Increase in AI075924 genebank mRNA level in human HEK293 cells at 5 uM after 48 hrs by microarray analysis [AID331016, Type: Literature]
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14
[SID103563347]
 Increase in AI521273 genebank mRNA level in human HEK293 cells at 5 uM after 48 hrs by microarray analysis [AID331017, Type: Literature]
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15
[SID103563347]
 Increase in BG054539 genebank mRNA level in human HEK293 cells at 5 uM after 48 hrs by microarray analysis [AID331018, Type: Literature]
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16
[SID103563347]
 Increase in AI668569 genebank mRNA level in human HEK293 cells at 5 uM after 48 hrs by microarray analysis [AID331019, Type: Literature]
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17
[SID103563347]
 Increase in N64758 genebank mRNA level in human HEK293 cells at 5 uM after 48 hrs by microarray analysis [AID331020, Type: Literature]
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18
[SID103563347]
 Induction of ribosomal readthrough of premature nonsense codon UAG LUC190 in human HEK293 cells after 16 hrs by luciferase assay [AID331021, Type: Literature]
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19
[SID103563347]
 Induction of ribosomal readthrough of premature nonsense codon UGA LUC190 in human HEK293 cells after 16 hrs by luciferase assay [AID331022, Type: Literature]
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20
[SID103563347]
 Antimicrobial activity against Escherichia coli BAS849 [AID330982, Type: Literature]
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21
[SID103563347]
 Antimicrobial activity against Pseudomonas aeruginosa 27853 [AID330983, Type: Literature]
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22
[SID103563347]
 Antimicrobial activity against Staphylococcus aureus 29213 [AID330984, Type: Literature]
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23
[SID103563347]
 Antimicrobial activity against Staphylococcus epidermis [AID330985, Type: Literature]
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24
[SID103563347]
 Antimicrobial activity against Enterococcus faecium 49624 [AID330986, Type: Literature]
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25
[SID103563347]
 Antimicrobial activity against Enterococcus faecalis 29212 [AID330987, Type: Literature]
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26
[SID103563347]
 Drug level in Sprague-Dawley male rat plasma at 300 mg/kg after 14 days [AID330988, Type: Literature]
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27
[SID103563347]
 Drug level in Sprague-Dawley female rat plasma at 300 mg/kg after 14 days [AID330989, Type: Literature]
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28
[SID103563347]
 Drug level in Sprague-Dawley male rat plasma at 600 mg/kg after 14 days [AID330990, Type: Literature]
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29
[SID103563347]
 Drug level in Sprague-Dawley female rat plasma at 600 mg/kg after 14 days [AID330991, Type: Literature]
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30
[SID103563347]
 Drug level in Sprague-Dawley male rat plasma at 1800 mg/kg after 14 days [AID330992, Type: Literature]
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31
[SID103563347]
 Drug level in Sprague-Dawley female rat plasma at 1800 mg/kg after 14 days [AID330993, Type: Literature]
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32
[SID103563347]
 Drug level in dog plasma at 500 mg/kg after 11 days [AID330994, Type: Literature]
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33
[SID103563347]
 Drug level in dog plasma at 1500 mg/kg after 11 days [AID330995, Type: Literature]
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34
[SID103563347]
 Decrease in LCN8 mRNA level in human HEK293 cells at 5 uM after 48 hrs by microarray analysis [AID330996, Type: Literature]
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35
[SID103563347]
 Decrease in MECP2 mRNA level in human HEK293 cells at 5 uM after 48 hrs by microarray analysis [AID330997, Type: Literature]
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36
[SID103563347]
 Decrease in CSMD1 mRNA level in human HEK293 cells at 5 uM after 48 hrs by microarray analysis [AID330998, Type: Literature]
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37
[SID103563347]
 Decrease in MRPL41mRNA level in human HEK293 cells at 5 uM after 48 hrs by microarray analysis [AID330999, Type: Literature]
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38
[SID103563347]
 Decrease in ARHGEF12 mRNA level in human HEK293 cells at 5 uM after 48 hrs by microarray analysis [AID331000, Type: Literature]
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39
[SID103563347]
 Decrease in LOC255798 mRNA level in human HEK293 cells at 5 after 48 hrs uM by microarray analysis [AID331001, Type: Literature]
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40
[SID103563347]
 Decrease in SLC7A1 mRNA level in human HEK293 cells at 5 uM after 48 hrs by microarray analysis [AID331002, Type: Literature]
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41
[SID103563347]
 Decrease in ZNF206 mRNA level in human HEK293 cells at 5 uM after 48 hrs by microarray analysis [AID331003, Type: Literature]
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42
[SID103563347]
 Decrease in HRASLS2 mRNA level in human HEK293 cells at 5 uM after 48 hrs by microarray analysis [AID331004, Type: Literature]
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43
[SID103563347]
 Increase in LOC220980 mRNA level in human HEK293 cells at 5 uM after 48 hrs by microarray analysis [AID331005, Type: Literature]
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44
[SID103563347]
 Increase in CTRC mRNA level in human HEK293 cells at 5 uM after 48 hrs by microarray analysis [AID331006, Type: Literature]
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45
[SID103563347]
 Increase in INSL3 mRNA level in human HEK293 cells at 5 uM after 48 hrs by microarray analysis [AID331007, Type: Literature]
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46
[SID103563347]
 Induction of ribosomal readthrough of premature nonsense codon UAA LUC190 in human HEK293 cells after 16 hrs by luciferase assay [AID330974, Type: Literature]
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47
[SID103563347]
 Increase in ORTC1 mRNA level in human HEK293 cells at 5 uM after 48 hrs by microarray analysis [AID331008, Type: Literature]
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48
[SID103563347]
 Increase in XLHSRF1 mRNA level in human HEK293 cells at 5 uM after 48 hrs by microarray analysis [AID331009, Type: Literature]
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49
[SID103563347]
 Ratio of dystrophin to myosine in mdx mouse myotubes at 10 ug/ml relative to wild type C57-mouse [AID331010, Type: Literature]
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50
[SID103563347]
 Effect on LUC190 CD40 mRNA assessed as luciferase accumulation in human HEK293 cells by western blotting [AID331011, Type: Literature]
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