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ataluren (CID 11219835) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(22)
 
 
Inactive(130)
 
 
Inconclusive(41)
 
 
Unspecified(44)
 
 
Top Targets:
NR LBD PPAR(8)
 
 
 
NR LBD AR(7)
 
 
 
 
NR LBD ER(7)
 
 
 
 
7TM GPCR Srx(5)
 
 
NR LBD GR(4)
 
 
 
BioAssay Types:
Literature(114)
 
 
 
 
Confirmatory(92)
 
 
 
 
Summary(24)
 
 
 
 
Screening(7)
 
 
 
BioActivity Types:
Potency(110)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 176    Data Row: 237   Total Pages: 5   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144206184]
AhR Potency (uM) 0.00211317qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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2
[SID85852879]
Potency 0.0072Biochemical firefly luciferase enzyme assay for NPC [AID624030, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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3
[SID144206184]
Potency-Replicate_1 0.0119qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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4
[SID144206184]
Potency-Replicate_1 0.0237qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 [AID651632, Type: confirmatory]ATPase family AAA domain-containing protein 5 [gi:296439460]
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5
[SID144206184]
ATAD5 Potency (uM) 0.027644qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5: Summary [AID720516, Type: summary]ATPase family AAA domain-containing protein 5 [gi:296439460]
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6
[SID85852879]
Potency 0.3013Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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7
[SID144206184]
Potency-Replicate_1 0.4731qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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8
[SID85852879]
Potency 0.7079VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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9
[SID99460885]
Potency 2.6351qHTS Assay for Lipid Storage Modulators: 3T3L1 Assay against Probe and Analogs [AID652180, Type: confirmatory]
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10
[SID144206184]
Potency 3.1623qHTS for Inhibitors of binding or entry into cells for Marburg Virus [AID720532, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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11
[SID144206184]
Potency 8.9125qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID720533, Type: confirmatory]
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12
[SID144206184]
TR Potency (uM) 9.99848qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway: Summary [AID743067, Type: summary]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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13
[SID144206184]
Potency-Replicate_1 10.5909qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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14
[SID170466862]
Potency-Replicate_1 11.8823qHTS assay to identify small molecule antagonists of the farnesoid-X-receptor (FXR) signaling pathway - cell viability counter screen [AID743221, Type: confirmatory]
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15
[SID144206184]
Potency-Replicate_1 29.8493qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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16
[SID103563347]
Induction of ribosomal readthrough of dystrophin mRNA premature nonsense codons in primary muscle cell culture at 17 uM by immunocytometry [AID330976, Type: Literature]
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17
[SID87334013]
Thermal Shift Assay for Inhibitors of FLuc (Firefly Luciferase, Photinus pyralis) in Presence of ATP [AID2228, Type: screening]Luciferase [Photinus pyralis] [gi:160794]
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18
[SID87334013]
Thermal Shift Assay for Inhibitors of FLuc (Firefly Luciferase, Photinus pyralis) in Absence of ATP [AID2229, Type: screening]Luciferase [Photinus pyralis] [gi:160794]
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19
[SID103563347]
Reduction in serum creatinine levels in orally and ip dosed mdx mouse Extensor digitorum longus muscle after 2 weeks [AID330978, Type: Literature]
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20
[SID103563347]
Increase in level of gamma sarcoplycan in mdx mouse muscle [AID330979, Type: Literature]
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21
[SID103563347]
Effect on production of dystrophin in mdx mouse muscle by western blotting [AID330980, Type: Literature]
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22
[SID103563347]
Induction of readthrough of normal termination codon of beta-2 microglobulin mRNA in human pooled PBMC cells at 200 mg/kg, po by western blotting [AID331013, Type: Literature]
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23
[SID103563347]
Decrease in AW4749 genebank mRNA level in human HEK293 cells at 5 uM after 48 hrs by microarray analysis [AID331014, Type: Literature]
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24
[SID103563347]
Increase in AA844509 genebank mRNA level in human HEK293 cells at 5 uM after 48 hrs by microarray analysis [AID331015, Type: Literature]
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25
[SID103563347]
Increase in AI075924 genebank mRNA level in human HEK293 cells at 5 uM after 48 hrs by microarray analysis [AID331016, Type: Literature]
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26
[SID103563347]
Increase in AI521273 genebank mRNA level in human HEK293 cells at 5 uM after 48 hrs by microarray analysis [AID331017, Type: Literature]
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27
[SID103563347]
Increase in BG054539 genebank mRNA level in human HEK293 cells at 5 uM after 48 hrs by microarray analysis [AID331018, Type: Literature]
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28
[SID103563347]
Increase in AI668569 genebank mRNA level in human HEK293 cells at 5 uM after 48 hrs by microarray analysis [AID331019, Type: Literature]
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29
[SID103563347]
Increase in N64758 genebank mRNA level in human HEK293 cells at 5 uM after 48 hrs by microarray analysis [AID331020, Type: Literature]
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30
[SID103563347]
Induction of ribosomal readthrough of premature nonsense codon UAG LUC190 in human HEK293 cells after 16 hrs by luciferase assay [AID331021, Type: Literature]
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31
[SID103563347]
Induction of ribosomal readthrough of premature nonsense codon UGA LUC190 in human HEK293 cells after 16 hrs by luciferase assay [AID331022, Type: Literature]
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32
[SID103563347]
Aqueous solubility of the compound [AID330973, Type: Literature]
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33
[SID103563347]
Induction of ribosomal readthrough of premature nonsense codon UAA LUC190 in human HEK293 cells after 16 hrs by luciferase assay [AID330974, Type: Literature]
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34
[SID103563347]
Antimicrobial activity against Escherichia coli BAS849 [AID330982, Type: Literature]
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35
[SID103563347]
Antimicrobial activity against Pseudomonas aeruginosa 27853 [AID330983, Type: Literature]
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36
[SID103563347]
Antimicrobial activity against Staphylococcus aureus 29213 [AID330984, Type: Literature]
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37
[SID103563347]
Antimicrobial activity against Staphylococcus epidermis [AID330985, Type: Literature]
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38
[SID103563347]
Antimicrobial activity against Enterococcus faecium 49624 [AID330986, Type: Literature]
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39
[SID103563347]
Antimicrobial activity against Enterococcus faecalis 29212 [AID330987, Type: Literature]
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40
[SID103563347]
Drug level in Sprague-Dawley male rat plasma at 300 mg/kg after 14 days [AID330988, Type: Literature]
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41
[SID103563347]
Drug level in Sprague-Dawley female rat plasma at 300 mg/kg after 14 days [AID330989, Type: Literature]
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42
[SID103563347]
Drug level in Sprague-Dawley male rat plasma at 600 mg/kg after 14 days [AID330990, Type: Literature]
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43
[SID103563347]
Drug level in Sprague-Dawley female rat plasma at 600 mg/kg after 14 days [AID330991, Type: Literature]
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44
[SID103563347]
Drug level in Sprague-Dawley male rat plasma at 1800 mg/kg after 14 days [AID330992, Type: Literature]
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45
[SID103563347]
Drug level in Sprague-Dawley female rat plasma at 1800 mg/kg after 14 days [AID330993, Type: Literature]
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46
[SID103563347]
Drug level in dog plasma at 500 mg/kg after 11 days [AID330994, Type: Literature]
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47
[SID103563347]
Drug level in dog plasma at 1500 mg/kg after 11 days [AID330995, Type: Literature]
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48
[SID103563347]
Decrease in LCN8 mRNA level in human HEK293 cells at 5 uM after 48 hrs by microarray analysis [AID330996, Type: Literature]
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49
[SID103563347]
Decrease in MECP2 mRNA level in human HEK293 cells at 5 uM after 48 hrs by microarray analysis [AID330997, Type: Literature]
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50
[SID103563347]
Decrease in CSMD1 mRNA level in human HEK293 cells at 5 uM after 48 hrs by microarray analysis [AID330998, Type: Literature]
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