841290-80-0 (CID 11213558) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(380)
 
 
Inactive(82)
 
 
Inconclusive(3)
 
 
Unspecified(145)
 
 
Top Targets:
PKc(55)
 
 
 
PKc like(34)
 
 
 
STKc AGC(24)
 
 
 
PTKc Abl(16)
 
 
 
PTKc EGFR(12)
 
 
 
BioAssay Types:
Literature(595)
 
 
 
 
Confirmatory(11)
 
 
 
 
BioActivity Types:
Kd(442)
 
 
 
Potency(11)
 
 
 
 
IC50(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 456    Data Row: 610   Total Pages: 13   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103596121]
Kd 0.00037Binding constant for FLT3(D835Y) kinase domain [AID624936, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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2
[SID103596121]
Kd 0.00037Binding constant for FLT3(D835Y) kinase domain [AID624936, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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3
[SID103596121]
Kd 0.00037Binding constant for FLT3(D835Y) kinase domain [AID624936, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
4
[SID103596121]
Kd 0.00054Binding constant for FLT3(ITD) kinase domain [AID624937, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
5
[SID103596121]
Kd 0.00054Binding constant for FLT3(ITD) kinase domain [AID624937, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
6
[SID103596121]
Kd 0.00054Binding constant for FLT3(ITD) kinase domain [AID624937, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
7
[SID103596121]
Kd 0.00065Binding constant for FLT3(D835H) kinase domain [AID624935, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
8
[SID103596121]
Kd 0.00065Binding constant for FLT3(D835H) kinase domain [AID624935, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
9
[SID103596121]
Kd 0.00065Binding constant for FLT3(D835H) kinase domain [AID624935, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
10
[SID103596121]
Kd 0.00068Binding constant for FLT3(K663Q) kinase domain [AID624938, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
11
[SID103596121]
Kd 0.00068Binding constant for FLT3(K663Q) kinase domain [AID624938, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
12
[SID103596121]
Kd 0.00068Binding constant for FLT3(K663Q) kinase domain [AID624938, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
13
[SID103596121]
Kd 0.00071Binding constant for FLT3 kinase domain [AID624934, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
14
[SID103596121]
Kd 0.00071Binding constant for FLT3 kinase domain [AID624934, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
15
[SID103596121]
Kd 0.00071Binding constant for FLT3 kinase domain [AID624934, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
16
[SID103596121]
Kd 0.0015Binding constant for FLT3(N841I) kinase domain [AID624939, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
17
[SID103596121]
Kd 0.0015Binding constant for FLT3(N841I) kinase domain [AID624939, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
18
[SID103596121]
Kd 0.0015Binding constant for FLT3(N841I) kinase domain [AID624939, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
19
[SID103596121]
Kd 0.0017Binding constant for STK16 kinase domain [AID624775, Type: Literature]Serine/threonine-protein kinase 16 [gi:46577677]
View
20
[SID103596121]
Kd 0.0017Binding constant for STK16 kinase domain [AID624775, Type: Literature]Serine/threonine-protein kinase 16 [gi:46577677]
View
21
[SID103596121]
Kd 0.0017Binding constant for STK16 kinase domain [AID624775, Type: Literature]Serine/threonine-protein kinase 16 [gi:46577677]
View
22
[SID103596121]
Kd 0.0022Binding constant for RET(V804L) kinase domain [AID625123, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
View
23
[SID103596121]
Kd 0.0022Binding constant for RET(V804L) kinase domain [AID625123, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
View
24
[SID103596121]
Kd 0.0025Binding constant for KIT(D816V) kinase domain [AID624789, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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25
[SID103596121]
Kd 0.0025Binding constant for KIT(D816V) kinase domain [AID624789, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View
26
[SID103596121]
Kd 0.0031Binding constant for RET(V804M) kinase domain [AID625124, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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27
[SID103596121]
Kd 0.0031Binding constant for RET(V804M) kinase domain [AID625124, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
View
28
[SID103596121]
Kd 0.0033Binding constant for GCN2(Kin.Dom.2,S808G) kinase domain [AID624810, Type: Literature]Eukaryotic translation initiation factor 2-alpha kinase 4 [gi:296439368]
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29
[SID103596121]
Kd 0.0033Binding constant for GCN2(Kin.Dom.2,S808G) kinase domain [AID624810, Type: Literature]Eukaryotic translation initiation factor 2-alpha kinase 4 [gi:296439368]
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30
[SID103596121]
Kd 0.0033Binding constant for PDGFRB kinase domain [AID624875, Type: Literature]Platelet-derived growth factor receptor beta [gi:129890]
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31
[SID103596121]
Kd 0.0033Binding constant for PDGFRB kinase domain [AID624875, Type: Literature]Platelet-derived growth factor receptor beta [gi:129890]
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32
[SID103596121]
Kd 0.0035Binding constant for KIT(A829P) kinase domain [AID624787, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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33
[SID103596121]
Kd 0.0035Binding constant for KIT(A829P) kinase domain [AID624787, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View
34
[SID103596121]
Kd 0.0035Binding constant for JAK2(JH1domain-catalytic) kinase domain [AID624973, Type: Literature]Tyrosine-protein kinase JAK2 [gi:12643404]
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35
[SID103596121]
Kd 0.0035Binding constant for JAK2(JH1domain-catalytic) kinase domain [AID624973, Type: Literature]Tyrosine-protein kinase JAK2 [gi:12643404]
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36
[SID103596121]
Kd 0.0035Binding constant for JAK2(JH1domain-catalytic) kinase domain [AID624973, Type: Literature]Tyrosine-protein kinase JAK2 [gi:12643404]
View
37
[SID103596121]
Kd 0.0038Binding constant for MLK2 kinase domain [AID624867, Type: Literature]Mitogen-activated protein kinase kinase kinase 10 [gi:145559494]
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38
[SID103596121]
Kd 0.0038Binding constant for MLK2 kinase domain [AID624867, Type: Literature]Mitogen-activated protein kinase kinase kinase 10 [gi:145559494]
View
39
[SID103596121]
Kd 0.0041Binding constant for RET kinase domain [AID625121, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
View
40
[SID103596121]
Kd 0.0041Binding constant for RET kinase domain [AID625121, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
View
41
[SID103596121]
Kd 0.0041Binding constant for RET(M918T) kinase domain [AID625122, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
View
42
[SID103596121]
Kd 0.0041Binding constant for RET(M918T) kinase domain [AID625122, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
View
43
[SID103596121]
Kd 0.0042Binding constant for PLK4 kinase domain [AID625076, Type: Literature]Serine/threonine-protein kinase PLK4 [gi:160113150]
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44
[SID103596121]
Kd 0.0042Binding constant for PLK4 kinase domain [AID625076, Type: Literature]Serine/threonine-protein kinase PLK4 [gi:160113150]
View
45
[SID103596121]
Kd 0.0043Binding constant for MLK1 kinase domain [AID624706, Type: Literature]Mitogen-activated protein kinase kinase kinase 9 [gi:116242625]
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46
[SID103596121]
Kd 0.0043Binding constant for MLK1 kinase domain [AID624706, Type: Literature]Mitogen-activated protein kinase kinase kinase 9 [gi:116242625]
View
47
[SID103596121]
Kd 0.0044Binding constant for FLT3(R834Q) kinase domain [AID624940, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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48
[SID103596121]
Kd 0.0044Binding constant for FLT3(R834Q) kinase domain [AID624940, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
49
[SID103596121]
Kd 0.0044Binding constant for FLT3(R834Q) kinase domain [AID624940, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
50
[SID103596121]
Kd 0.0051Binding constant for PLK3 kinase domain [AID624933, Type: Literature]Serine/threonine-protein kinase PLK3 [gi:51338822]
View