Bookmark and Share
841290-80-0 (CID 11213558) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(399)
 
 
Inactive(91)
 
 
Inconclusive(4)
 
 
Unspecified(149)
 
 
Top Targets:
PKc(48)
 
 
 
PKc like(40)
 
 
 
STKc AGC(17)
 
 
 
PTKc Abl(16)
 
 
 
PTKc EGFR(12)
 
 
 
BioAssay Types:
Literature(618)
 
 
 
 
Confirmatory(21)
 
 
 
 
BioActivity Types:
Kd(442)
 
 
 
Potency(23)
 
 
 
 
EC50(14)
 
 
IC50(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 488    Data Row: 643   Total Pages: 13   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103596121]
Kd 0.00037Binding constant for FLT3(D835Y) kinase domain [AID624936, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
2
[SID103596121]
Kd 0.00054Binding constant for FLT3(ITD) kinase domain [AID624937, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
3
[SID103596121]
Kd 0.00065Binding constant for FLT3(D835H) kinase domain [AID624935, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
4
[SID103596121]
Kd 0.00068Binding constant for FLT3(K663Q) kinase domain [AID624938, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
5
[SID103596121]
Kd 0.00071Binding constant for FLT3 kinase domain [AID624934, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
6
[SID103596121]
Kd 0.0015Binding constant for FLT3(N841I) kinase domain [AID624939, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
7
[SID103596121]
Kd 0.0017Binding constant for STK16 kinase domain [AID624775, Type: Literature]Serine/threonine-protein kinase 16 [gi:46577677]
View
8
[SID103596121]
Kd 0.0022Binding constant for RET(V804L) kinase domain [AID625123, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
View
9
[SID103596121]
Kd 0.0025Binding constant for KIT(D816V) kinase domain [AID624789, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View
10
[SID103596121]
Kd 0.0031Binding constant for RET(V804M) kinase domain [AID625124, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
View
11
[SID103596121]
Kd 0.0033Binding constant for PDGFRB kinase domain [AID624875, Type: Literature]Platelet-derived growth factor receptor beta [gi:129890]
View
12
[SID103596121]
Kd 0.0033Binding constant for GCN2(Kin.Dom.2,S808G) kinase domain [AID624810, Type: Literature]Eukaryotic translation initiation factor 2-alpha kinase 4 [gi:296439368]
View
13
[SID103596121]
Kd 0.0035Binding constant for KIT(A829P) kinase domain [AID624787, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View
14
[SID103596121]
Kd 0.0035Binding constant for JAK2(JH1domain-catalytic) kinase domain [AID624973, Type: Literature]Tyrosine-protein kinase JAK2 [gi:12643404]
View
15
[SID103596121]
Kd 0.0038Binding constant for MLK2 kinase domain [AID624867, Type: Literature]Mitogen-activated protein kinase kinase kinase 10 [gi:145559494]
View
16
[SID103596121]
Kd 0.0041Binding constant for RET kinase domain [AID625121, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
View
17
[SID103596121]
Kd 0.0041Binding constant for RET(M918T) kinase domain [AID625122, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
View
18
[SID103596121]
Kd 0.0042Binding constant for PLK4 kinase domain [AID625076, Type: Literature]Serine/threonine-protein kinase PLK4 [gi:160113150]
View
19
[SID103596121]
Kd 0.0043Binding constant for MLK1 kinase domain [AID624706, Type: Literature]Mitogen-activated protein kinase kinase kinase 9 [gi:116242625]
View
20
[SID103596121]
Kd 0.0044Binding constant for FLT3(R834Q) kinase domain [AID624940, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
21
[SID103596121]
IC50 0.005Inhibition of Ret by biochemical assay [AID700931, Type: Literature]
View
22
[SID103596121]
Kd 0.0051Binding constant for PLK3 kinase domain [AID624933, Type: Literature]Serine/threonine-protein kinase PLK3 [gi:51338822]
View
23
[SID103596121]
Kd 0.0056Binding constant for KIT(L576P) kinase domain [AID624790, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View
24
[SID103596121]
Kd 0.0057Binding constant for KIT(V559D) kinase domain [AID624791, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View
25
[SID103596121]
Kd 0.0063Binding constant for NEK6 kinase domain [AID625079, Type: Literature]Serine/threonine-protein kinase Nek6 [gi:37537993]
View
26
[SID103596121]
Kd 0.0065Binding constant for KIT(D816H) kinase domain [AID624788, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View
27
[SID103596121]
Kd 0.0068Binding constant for KIT kinase domain [AID624786, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View
28
[SID103596121]
Kd 0.0071Binding constant for ULK3 kinase domain [AID624818, Type: Literature]Serine/threonine-protein kinase ULK3 [gi:259016166]
View
29
[SID103596121]
Kd 0.0084Binding constant for SRC kinase domain [AID625016, Type: Literature]Proto-oncogene tyrosine-protein kinase Src [gi:125711]
View
30
[SID103596121]
Kd 0.0091Binding constant for FLT4 kinase domain [AID624854, Type: Literature]Vascular endothelial growth factor receptor 3 [gi:357529070]
View
31
[SID103596121]
Kd 0.0092Binding constant for DRAK2 kinase domain [AID624942, Type: Literature]Serine/threonine-protein kinase 17B [gi:14423909]
View
32
[SID103596121]
Kd 0.0093Binding constant for DDR1 kinase domain [AID624850, Type: Literature]Epithelial discoidin domain-containing receptor 1 [gi:729008]
View
33
[SID103596121]
Kd 0.0097Binding constant for IRAK1 kinase domain [AID624837, Type: Literature]Interleukin-1 receptor-associated kinase 1 [gi:8928535]
View
34
[SID103596121]
EC50 0.01Inhibition of Mitogen-activated protein kinase p38 in OVA-challenged and IgE-sensitized cells [AID701074, Type: Literature]
View
35
[SID103596121]
EC50 0.01Inhibition of ERK1/2 in OVA-challenged and IgE-sensitized cells [AID701075, Type: Literature]
View
36
[SID103596121]
EC50 0.01Inhibition of SYK in OVA-challenged and IgE-sensitized cells assessed as reduction in IL2 release [AID701078, Type: Literature]
View
37
[SID103596121]
EC50 0.01Inhibition of JNK2 in OVA-challenged and IgE-sensitized cells [AID700924, Type: Literature]
View
38
[SID103596121]
EC50 0.01Inhibition of JNK1 in OVA-challenged and IgE-sensitized cells [AID700925, Type: Literature]
View
39
[SID103596121]
EC50 0.01Inhibition of SYK in OVA-challenged and IgE-sensitized cells assessed as reduction in TNFalpha release [AID700926, Type: Literature]
View
40
[SID103596121]
EC50 0.01Inhibition of SYK in OVA-challenged and IgE-sensitized cells assessed as reduction in IL13 release [AID700927, Type: Literature]
View
41
[SID103596121]
EC50 0.01Inhibition of SYK in OVA-challenged and IgE-sensitized cells assessed as reduction in IL6 release [AID700928, Type: Literature]
View
42
[SID103596121]
Kd 0.011Binding constant for KIT(V559D,T670I) kinase domain [AID624792, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View
43
[SID103596121]
Kd 0.011Binding constant for NEK7 kinase domain [AID624754, Type: Literature]Serine/threonine-protein kinase Nek7 [gi:37537965]
View
44
[SID103596121]
Kd 0.011Binding constant for MLK3 kinase domain [AID624866, Type: Literature]Mitogen-activated protein kinase kinase kinase 11 [gi:71153819]
View
45
[SID103596121]
Kd 0.011Binding constant for IRAK3 kinase domain [AID625066, Type: Literature]Interleukin-1 receptor-associated kinase 3 [gi:322510038]
View
46
[SID103596121]
Kd 0.013Binding constant for NEK5 kinase domain [AID624742, Type: Literature]Serine/threonine-protein kinase Nek5 [gi:74758252]
View
47
[SID103596121]
Kd 0.013Binding constant for DAPK3 kinase domain [AID624834, Type: Literature]Death-associated protein kinase 3 [gi:38604691]
View
48
[SID103596121]
Kd 0.013Binding constant for IKK-epsilon kinase domain [AID625074, Type: Literature]Inhibitor of nuclear factor kappa-B kinase subunit epsilon [gi:14548079]
View
49
[SID103596121]
Kd 0.014Binding constant for CSNK2A2 kinase domain [AID624849, Type: Literature]Casein kinase II subunit alpha' [gi:125266]
View
50
[SID103596121]
Kd 0.014Binding constant for ULK1 kinase domain [AID624916, Type: Literature]Serine/threonine-protein kinase ULK1 [gi:317373288]
View