Bookmark and Share
CHEMBL190346 (CID 11198061) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(52)
 
 
Inactive(492)
 
 
Inconclusive(27)
 
 
Unspecified(6)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
 
7TM GPCR Srsx(16)
 
 
 
KCNQ channel(9)
 
 
 
ABCC CFTR1(9)
 
 
 
 
CAP ED(5)
 
 
BioAssay Types:
Screening(385)
 
 
 
 
Confirmatory(167)
 
 
 
 
 
Literature(17)
 
 
 
 
BioActivity Types:
Potency(121)
 
 
 
 
 
IC50(41)
 
 
 
 
EC50(7)
 
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 518    Data Row: 577   Total Pages: 29   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103459736]
EC50 0.0026Effective concentration against Abeta(sw) peptide [AID246039, Type: Literature]
View
2
[SID103459736]
EC50 0.0114Beta-secretase inhibitory activity as inhibition of secreted alkaline phosphatase in HEK293 cells expressing SEAP-APP fusion protein [AID240366, Type: Literature]Beta-secretase 2 [gi:6685260]
View
3
[SID103459736]
EC50 0.0114Beta-secretase inhibitory activity as inhibition of secreted alkaline phosphatase in HEK293 cells expressing SEAP-APP fusion protein [AID240366, Type: Literature]Beta-secretase 1 [gi:296434407]
View
4
[SID103459736]
CC50 0.0233Cytotoxic concentration against human and other tumor cell lines [AID245927, Type: Literature]
View
5
[SID49641958]
IC50 1.2705HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction [AID2485, Type: confirmatory]tumor necrosis factor [Homo sapiens] [gi:25952111]
View
6
[SID49641958]
IC50_Mean 1.77Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a TNFa-induced IL8 counterscreen [AID624347, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
View
7
[SID49641958]
IC50 2.39uHTS luminescence assay for the identification of compounds that inhibit NOD2 in MDP treated cells [AID2001, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 isoform 1 [Homo sapiens] [gi:11545912]
View
8
[SID49641958]
EC50 4.27uHTS luminescence assay for the identification of compounds that inhibit NOD1 [AID1578, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
View
9
[SID49641958]
IC50_Mean 5.42Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a PAF-induced IL8 counterscreen [AID624343, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
View
10
[SID49641958]
EC50 6.47uHTS luminescence assay for the identification of compounds that inhibit NOD2 [AID1566, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 isoform 1 [Homo sapiens] [gi:11545912]
View
11
[SID49641958]
Potency 10qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [Marburg marburgvirus] [gi:420597]
View
12
[SID49641958]
Potency 11.2202qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
View
13
[SID49641958]
Potency 16.3601A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
View
14
[SID49641958]
Potency 19.0115qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
View
15
[SID49641958]
Potency 25.1189qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS [AID624288, Type: confirmatory]Guanine nucleotide-binding protein G(s) subunit alpha isoforms short [gi:52000961]
View
16
[SID103459736]
Ki 28.8Predicted binding affinity for beta secretase by linear interaction energy continuum electrostatics [AID239369, Type: Literature]
View
17
[SID49641958]
Full deck counterscreen for agonists of the human M1 muscarinic receptor (CHRM1): Fluorescence-based cell-based high throughput screening assay to identify nonselective activators and assay artifacts using the parental CHOK1 cell line [AID602248, Type: screening]
View
18
[SID49641958]
Full deck counterscreen for antagonists of the human M1 muscarinic receptor (CHRM1): Fluorescence-based cell-based high throughput screening assay to identify nonselective inhibitors and assay artifacts using the parental CHOK1 cell line [AID602250, Type: screening]
View
19
[SID49641958]
uHTS identification of small molecule inhibitors of the mitochondrial permeability transition pore via an absorbance assay [AID602449, Type: screening]
View
20
[SID49641958]
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]Breast cancer type 1 susceptibility protein [gi:728984]
View