Glycylglycine (CID 11163) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(1)
 
 
Inactive(2)
 
 
Unspecified(15)
 
 
Top Targets:
PTR2(5)
 
 
PTR2(1)
 
 
BioAssay Types:
Literature(13)
 
 
 
 
BioActivity Types:
Ki(5)
 
 
IC50(2)
 
 
EC50(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 18    Data Row: 18   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103242284]
 Inhibition of Streptococcus pyogenes His-tagged IdeS expressed in Escherichia coli BL21 using IgG1 as substrate at 30 mM incubated for 15 mins prior to substrate addition measured after 20 mins [AID664607, Type: Literature]
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2
[SID103242284]
Ki 42TP_TRANSPORTER: inhibition of Gly-Sar uptake in PEPT2-expressing LLC-PK1 cells [AID681124, Type: other]
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3
[SID103242284]
Ki 54Binding affinity to human PepT2 in SKTP cells [AID612540, Type: Literature]Solute carrier family 15 member 2 [gi:209572672]
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4
[SID103242284]
EC50 480Activation of human PEPT1 expressed in MDCK cells [AID266246, Type: Literature]Solute carrier family 15 member 1 [gi:1172435]
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5
[SID103242284]
IC50 820Binding affinity to human PEPT1 assessed as inhibition of [14C]Gly-Sar uptake in MDCK cells [AID266249, Type: Literature]Solute carrier family 15 member 1 [gi:1172435]
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6
[SID103242284]
Ki 860TP_TRANSPORTER: inhibition of Gly-Sar uptake in PEPT1-expressing LLC-PK1 cells [AID681125, Type: other]
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7
[SID103242284]
Ki 1000Binding affinity against membrane transport protein PEPT1 in human Caco-2 cells [AID238858, Type: Literature]Solute carrier family 15 member 1 [gi:1172435]
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8
[SID103242284]
Ki 1000Inhibition constant (Ki) for human intestinal peptide carrier [AID92023, Type: Literature]
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9
[SID103242284]
IC50 7244.36Biological activity was measured against Angiotensin I converting enzyme [AID38876, Type: Literature]
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10
[SID103242284]
 Partition coefficient (logP) [AID26797, Type: Literature]
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11
[SID103242284]
 Bitter threshold value; NB denotes 'Not bitter' [AID233320, Type: Literature]
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12
[SID103242284]
Km TP_TRANSPORTER: uptake in PEPT2-expressing HeLa cells [AID678988, Type: other]
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13
[SID103242284]
 TP_TRANSPORTER: inhibition of VACV uptake (VACV: 20 uM, Gly-Gly: 10000 uM) in PEPT1-expressing CHO cells [AID680827, Type: other]
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14
[SID103242284]
 Ratio of %GSmax to EC50 for human PEPT1 activation [AID266248, Type: Literature]Solute carrier family 15 member 1 [gi:1172435]
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15
[SID103242284]
 Inhibition of nitrogen-starved wild type sigma1278b yeast Gap1-mediated amino acid uptake at 5 mM after 60 secs relative to L-citrulline [AID500816, Type: Literature]
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16
[SID103242284]
 Activation of human PEPT1 expressed in MDCK cells relative to Gly-Sar [AID266247, Type: Literature]Solute carrier family 15 member 1 [gi:1172435]
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17
[SID101550]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model P388 Leukemia (intraperitoneal) in CD2F1 (CDF1) mice [AID330, Type: other]
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18
[SID103242284]
 Inhibition of Streptococcus pyogenes His-tagged IdeS expressed in Escherichia coli BL21 using IgG1 as substrate at 30 mM incubated for 15 mins prior to substrate addition measured after 20 mins by SDS-PAGE analysis [AID664611, Type: Literature]
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