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AGN-PC-0NGRB1 (CID 11153014) - Compound BioActivity Data
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BioActivity Outcomes:
Active(33)
 
 
Unspecified(23)
 
 
Top Targets:
PTKc Lck Blk(2)
 
 
SH2 Src Fgr(1)
 
 
SH2 Src HCK(1)
 
 
PTKc EGFR(1)
 
 
PTKc Src(1)
 
 
BioAssay Types:
Literature(56)
 
 
 
BioActivity Types:
IC50(34)
 
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 55    Data Row: 56   Total Pages: 3   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103454583]
Ki 0.00013In vitro inhibitory activity against recombinant p56 lck tyrosine kinase expressed as a His-tagged protein in insect cells [AID239502, Type: Literature]
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2
[SID103454583]
IC50 0.0008Inhibition of Fgr [AID271956, Type: Literature]Tyrosine-protein kinase Fgr [gi:125358]
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3
[SID103454583]
IC50 0.001Inhibition of Fyn [AID271967, Type: Literature]Tyrosine-protein kinase Fyn [gi:125370]
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4
[SID103454583]
IC50 0.001Inhibition of human Lck in presence of ATP [AID271946, Type: Literature]Tyrosine-protein kinase Lck [gi:125474]
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5
[SID103454583]
IC50 0.001inhibitory activity against Fyn protein kinase [AID240651, Type: Literature]
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6
[SID103454583]
IC50 0.001Inhibitory activity against Lck tyrosine kinase [AID240659, Type: Literature]
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7
[SID103454583]
IC50 0.001Inhibitory activity against Src tyrosine kinase [AID240660, Type: Literature]
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8
[SID103454583]
IC50 0.001Inhibitory activity against B lymphoid tyrosine kinase [AID240817, Type: Literature]
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9
[SID103454583]
IC50 0.001Inhibitory activity against Fgr kinase [AID240534, Type: Literature]
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10
[SID103454583]
IC50 0.0012In vitro inhibitory activity against recombinant p56 lck tyrosine kinase expressed as a His-tagged protein in insect cells [AID242530, Type: Literature]
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11
[SID103454583]
IC50 0.0016Antiproliferative activity against human K562 cells after 72 hrs [AID282221, Type: Literature]
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12
[SID103454583]
IC50 0.002Inhibition of Src in presence of ATP [AID271950, Type: Literature]Proto-oncogene tyrosine-protein kinase Src [gi:125711]
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13
[SID103454583]
IC50 0.002Inhibition of Yes [AID271968, Type: Literature]Tyrosine-protein kinase Yes [gi:125870]
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14
[SID103454583]
IC50 0.002Inhibition of Hck [AID271955, Type: Literature]Tyrosine-protein kinase HCK [gi:20141296]
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15
[SID103454583]
IC50 0.002inhibitory activity against Hck kinase [AID240535, Type: Literature]
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16
[SID103454583]
IC50 0.003Inhibition of Bcr-Abl in presence of ATP [AID271951, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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17
[SID103454583]
IC50 0.003Inhibition of Bcr-Abl in presence of ATP [AID271951, Type: Literature]Breakpoint cluster region protein [gi:143811366]
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18
[SID103454583]
IC50 0.004Inhibition of Lyn [AID271969, Type: Literature]Tyrosine-protein kinase Lyn [gi:125480]
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19
[SID103454583]
IC50 0.006inhibitory activity against Janus kinase 3 [AID240595, Type: Literature]
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20
[SID103454583]
IC50 0.067Antiproliferative activity against human PC3 cells after 72 hrs [AID282222, Type: Literature]
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