1-(4-Bromo-phenyl)-4-(2-hydroxy-3-methoxy-benzylidene)-pyrazolidine-3,5-dione (CID 1104827) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(9)
 
 
Inactive(398)
 
 
Inconclusive(18)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(17)
 
 
7TM GPCR Srsx(6)
 
 
TRP 2(5)
 
 
alkPPc(4)
 
 
Peptidase C48(4)
 
 
BioAssay Types:
Screening(282)
 
 
 
Confirmatory(135)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(101)
 
 
 
 
 
IC50(25)
 
 
 
EC50(4)
 
 
AC50(3)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 426    Data Row: 426   Total Pages: 9   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49645153]
Potency 0.6702qHTS for Inhibitors of WRN Helicase [AID651768, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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2
[SID49645153]
Potency 1.9012qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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3
[SID49645153]
Potency 79.4328qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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4
[SID49645153]
Potency 79.4328qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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5
[SID49645153]
Potency 100.392qHTS Fluorescence Polarization (FP) Assay for Inhibitors of MLL CXXC domain - DNA interaction: Fluorescein FP [AID624160, Type: confirmatory]
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6
[SID49645153]
 Fluorescence-based confirmation biochemical high throughput screening assay for inhibitors of the Hepatitis C Virus non-structural protein 3 helicase (NS3) [AID1943, Type: screening]NS3 [Hepatitis C virus] [gi:125541954]
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7
[SID49645153]
 Fluorescence-based primary biochemical high throughput screening assay to identify inhibitors of the Hepatitis C Virus non-structural protein 3 helicase (NS3) [AID1800, Type: screening]NS3 [Hepatitis C virus] [gi:125541954]
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8
[SID49645153]
 uHTS identification of small molecule modulators of myocardial damage [AID588492, Type: screening]
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9
[SID49645153]
 Luminescence Microorganism Primary HTS to Identify Inhibitors of the SUMOylation Pathway Using a Temperature Sensitive Growth Reversal Mutant Mot1-301 [AID2716, Type: screening]
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10
[SID49645153]
 Primary cell-based screen for identification of compounds that inhibit the Choline Transporter (CHT) [AID488975, Type: screening]SLC5A7 gene product [Homo sapiens] [gi:11141885]
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11
[SID49645153]
 Primary cell-based screen for identification of compounds that inhibit the Choline Transporter (CHT) [AID488975, Type: screening]SLC5A7 gene product [Homo sapiens] [gi:11141885]
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12
[SID49645153]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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13
[SID49645153]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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14
[SID49645153]
Potency 1.9953qHTS Assay for Inhibitors of Influenza NS1 Protein Function [AID2326, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/WSN/1933(H1N1))] [gi:194352380]
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15
[SID49645153]
Potency 10qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS [AID624287, Type: confirmatory]Guanine nucleotide-binding protein G(s) subunit alpha isoforms short [gi:52000961]
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16
[SID49645153]
AC50 420Luminescence Whole-Organism Secondary Assay to Identify Compounds Inducing Growth of Temperature Sensitive Mutant Burl-1 [AID463199, Type: confirmatory]
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17
[SID49645153]
AC50 420Luminescence Whole-Organism Dose Retest to Confirm Inhibitors of the SUMOylation Pathway Using a Temperature Sensitive Growth Reversal Mutant Mot1-301 [AID463204, Type: confirmatory]
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18
[SID49645153]
 Phenotypic HTS multiplex for antifungal efflux pump inhibitors [AID485275, Type: screening]
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19
[SID49645153]
Potency qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
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20
[SID49645153]
 Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_SinglePoint_HTS_Activity [AID488862, Type: screening]
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21
[SID49645153]
 uHTS luminescence assay for the identification of chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation [AID435003, Type: screening]
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22
[SID49645153]
 uHTS luminescence assay for the identification of chemical inhibitors of B-cell specific antigen receptor-induced NF-kB activation [AID435022, Type: screening]
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23
[SID49645153]
 uHTS identification of small molecule activators of the adaptive arm of the Unfolded Protein response via a luminescent-based reporter assay [AID463104, Type: screening]
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24
[SID49645153]
IC50 Primary and Confirmatory Screening for Inhibitors of Bacterial Capsule Biogenesis [AID488966, Type: confirmatory]
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25
[SID49645153]
AC50 SUMO pathway Measured in Whole Organism System Using Plate Reader - 2059-03_Inhibitor_Dose_CherryPick_Activity [AID493004, Type: confirmatory]
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26
[SID49645153]
Potency qHTS Assay to Find Inhibitors of Chronic Active B-Cell Receptor Signaling [AID493014, Type: confirmatory]
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27
[SID49645153]
 Heat Shock Factor-1 (HSF-1) Measured in Cell-Based System Using Plate Reader - 2038-01_Activator_SinglePoint_HTS_Activity [AID504408, Type: screening]
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28
[SID49645153]
Potency Nrf2 qHTS screen for inhibitors: counterscreen for cytotoxicity [AID504648, Type: confirmatory]
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29
[SID49645153]
Potency Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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30
[SID49645153]
Potency Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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31
[SID49645153]
 Small Molecules that selectively kill Giardia lamblia: qHTS [AID540267, Type: screening]
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32
[SID49645153]
 Luminescence-based cell-based primary high throughput screening assay to identify activators of the GAA850 frataxin (FXN) promoter [AID540364, Type: screening]
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33
[SID49645153]
 MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_SinglePoint_HTS_Activity [AID588334, Type: screening]
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34
[SID49645153]
 Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis: Absorbance-based biochemical high throughput Glycerophosphate Dehydrogenase-Triosephosphate Isomerase (GDH-TPI) full deck assay to identify assay artifacts [AID588335, Type: screening]
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35
[SID49645153]
 HTS to Find Inhibitors of Pathogenic Pemphigus Antibodies [AID588358, Type: screening]
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36
[SID49645153]
 Cholera Quorum: HTS for inducers of light production in the absence ofautoinducers using BH1578 (luxS deficient, cqsA deficient) Measured in Microorganism System Using Plate Reader - 2132-01_Agonist_SinglePoint_HTS_Activity [AID588436, Type: screening]
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37
[SID49645153]
 MLPCN Ras selective lethality-BJeLR viability [AID1554, Type: screening]
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38
[SID49645153]
IC50 A Cell Based Assay for the Identification of Lead Compounds with Anti-Viral Activity Against West Nile Virus [AID1621, Type: confirmatory]
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39
[SID49645153]
 High Throughput Imaging Assay for Hepatic Lipid Droplet Formation [AID1656, Type: screening]
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40
[SID49645153]
 MLPCN Platelet Activation -Dense Granule Release [AID1663, Type: screening]
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41
[SID49645153]
 MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - inhibitors [AID1813, Type: screening]
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42
[SID49645153]
 MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - activators [AID1814, Type: screening]
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43
[SID49645153]
 Luminescence-based counterscreen assay for KLF5 inhibitors: cell-based high throughput screening assay to identify cytotoxic compounds using the IEC-6 intestinal epithelial cell line. [AID1825, Type: screening]
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44
[SID49645153]
IC50 A small molecule screen for inhibitors of the PhoP regulon in Salmonella Typhimurium [AID1863, Type: confirmatory]
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45
[SID49645153]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Polyadenylation [AID1875, Type: screening]
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46
[SID49645153]
 Luminescence Cell-Based/Microorganism Primary HTS to Identify Inhibitors of T.Cruzi Replication [AID1885, Type: screening]
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47
[SID49645153]
 Luminescence Cell-Based Primary HTS to Identify Transcriptional Activators of Hypoxia-Inducible Factor Pathway [AID1910, Type: screening]
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48
[SID49645153]
 Fluorescence Biochemical Primary HTS to Identify Inhibitors of GASC-1 Activity [AID2099, Type: screening]
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49
[SID49645153]
 Fluorescence Cell-Free Homogeneous Primary HTS to Identify Inhibitors of the RanGTP-Importin-beta complex [AID2216, Type: screening]
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50
[SID49645153]
IC50 A small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID1850, Type: confirmatory]
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