Spermine (CID 1103) - BioAssay Data Summary for Compound
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BioActivity Outcomes:
Active(41)
 
 
Top Targets:
alpha CA(3)
 
 
alpha CA XII..(3)
 
 
p450(3)
 
 
7TM GPCR Srx(1)
 
 
alpha CA IV X..(1)
 
 
BioAssay Types:
Literature(34)
 
 
Confirmatory(4)
 
 
BioActivity Types:
Ki(19)
 
 
IC50(6)
 
 
Potency(3)
 
 
EC50(2)
 
 
SAR
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 41    Data Row: 41   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103192063]
Ki 0.01Inhibition of human carbonic anhydrase 4 by stopped flow CO2 hydration method [AID496916, Type: Literature]Carbonic anhydrase 4 [gi:115465]
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2
[SID103192063]
Ki 0.2Inhibition of [3H]spermine transport by the compound was evaluated in ZR-75-1 human breast cancer cells [AID220401, Type: Literature]
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3
[SID103192063]
Ki 0.28Inhibition of [3H]spermidine transport into MDA-MB-231 (human breast cancer) cells. [AID101790, Type: Literature]
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4
[SID103192063]
IC50 0.39Compound was tested for inhibitory concentration required to inhibit 50% of [14C]- putrescine uptake. [AID101071, Type: Literature]
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5
[SID103192063]
Ki 0.65Inhibition of [3H]putrescine transport by the compound was evaluated in T-47D human breast cancer cells [AID210101, Type: Literature]
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6
[SID103192063]
Ki 0.71Inhibition of human carbonic anhydrase 7 by stopped flow CO2 hydration method [AID496920, Type: Literature]Carbonic anhydrase 7 [gi:1168744]
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7
[SID103192063]
Ki 0.83Inhibition of human carbonic anhydrase 5B by stopped flow CO2 hydration method [AID496918, Type: Literature]Carbonic anhydrase 5B, mitochondrial [gi:8928041]
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8
[SID103192063]
Ki 0.84Inhibition of human carbonic anhydrase 5A by stopped flow CO2 hydration method [AID496917, Type: Literature]Carbonic anhydrase 5A, mitochondrial [gi:461680]
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9
[SID103192063]
Ki 0.86Inhibition of human carbonic anhydrase 14 by stopped flow CO2 hydration method [AID496924, Type: Literature]Carbonic anhydrase 14 [gi:8928036]
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10
[SID103192063]
Ki 0.92Inhibition of [3H]spermidine transport by the compound was evaluated in T-47D human breast cancer cells [AID210103, Type: Literature]
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11
[SID103192063]
Ki 0.99Inhibition of human carbonic anhydrase 6 by stopped flow CO2 hydration method [AID496919, Type: Literature]Carbonic anhydrase 6 [gi:116241278]
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12
[SID103192063]
Ki 1.34Inhibition of [14C]spermidine uptake at polyamine transport system in mouse L1210 cells after 10 mins [AID536842, Type: Literature]
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13
[SID103192063]
Ki 1.34Binding affinity to the mouse polyamine transporter on the L1210 cell surface [AID160317, Type: Literature]
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14
[SID103192063]
ED50 2Effective dose required for binding to lipopolysaccharide using Fluorescence Displacement Assay; Range is ~1-2 uM [AID240418, Type: Literature]
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15
[SID103192063]
Km 2Michaelis menton constant of compound was determined at MDA-MB-231 cell line mediated by polyamine transporter [AID162587, Type: Literature]
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16
[SID103192063]
Ki 2.1Inhibition of spermidine transport determined in T-47D human breast cancer cells [AID210118, Type: Literature]
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17
[SID103192063]
Ki 2.7Inhibition of [3H]spermine transport by the compound was evaluated in T-47D human breast cancer cells [AID210105, Type: Literature]
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18
[SID103192063]
IC50 2.8Ability to displace ethidium bromide from double stranded synthetic Poly (dA-dT) [AID162413, Type: Literature]
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19
[SID103192063]
IC50 3Concentration required to decrease the fluorescence of the ethidium bromide-calf thymus DNA complex by 50% [AID54446, Type: other]
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20
[SID103192063]
IC50 4.3Ability to displace ethidium bromide from calf thymus DNA [AID54444, Type: Literature]
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21
[SID90341642]
Potency 4.6109HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: Hit Validation in HTRF [AID624455, Type: confirmatory]dopamine D1 receptor [Homo sapiens] [gi:299681]
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22
[SID90341642]
Potency 4.6109HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: Hit Validation in HTRF [AID624455, Type: confirmatory]dopamine D1 receptor [Homo sapiens] [gi:299681]
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23
[SID90341642]
Potency 4.6109HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: Hit Validation in HTRF [AID624455, Type: confirmatory]dopamine D1 receptor [Homo sapiens] [gi:299681]
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24
[SID90341642]
Potency 4.6109HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: Hit Validation in HTRF [AID624455, Type: confirmatory]dopamine D1 receptor [Homo sapiens] [gi:299681]
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25
[SID103192063]
EC50 5.2Ability to enhance [3H]MK-801 binding to NMDA receptors in rat forebrain membranes was calculated with respect to spermine [AID144318, Type: Literature]
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26
[SID103192063]
IC50 6Ability to displace ethidium bromide from double stranded synthetic poly (dG-dC) [AID162553, Type: Literature]
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27
[SID103192063]
CC50 6.8Drug concentration required to produce 50% inhibition of fluorescence bound ethidium to CT-DNA (1.26:1) (+/-SEM 5%) [AID220346, Type: Literature]
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28
[SID11113818]
Potency 7.9433qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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29
[SID11113818]
Potency 7.9433qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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30
[SID103192063]
EC50 8.5Activation of procaspase 2 after 24 hrs [AID328670, Type: Literature]
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31
[SID90341642]
Potency 12.5893qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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32
[SID103192063]
Ki 13.3Inhibition of human carbonic anhydrase 9 by stopped flow CO2 hydration method [AID496921, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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33
[SID103192063]
Ki 13.3Inhibition of human carbonic anhydrase 9 preincubated for 15 mins by CO2 hydration stopped-flow assay [AID568364, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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34
[SID103192063]
IC50 17Binding of compound to calf thymus DNA was determined by an ethidium bromide displacement assay [AID46156, Type: Literature]
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35
[SID103192063]
Ki 22.6Inhibition of mouse carbonic anhydrase 13 by stopped flow CO2 hydration method [AID496923, Type: Literature]Carbonic anhydrase 13 [gi:30580372]
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36
[SID103192063]
Ki 27.6Inhibition of human carbonic anhydrase 12 by stopped flow CO2 hydration method [AID496922, Type: Literature]Carbonic anhydrase 12 [gi:5915866]
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37
[SID103192063]
Ki 27.6Inhibition of human carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration stopped-flow assay [AID568365, Type: Literature]Carbonic anhydrase 12 [gi:5915866]
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38
[SID11113818]
 Cytochrome panel assay with activity outcomes [AID1851_1, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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39
[SID11113818]
 p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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40
[SID11113818]
 Cytochrome panel assay with activity outcomes [AID1851_1, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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41
[SID11113818]
 p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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42
[SID11113818]
 p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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43
[SID85209806]
 Ligands of Class C GPCRs [AID2059, Type: other]
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44
[SID103192063]
 Activation of chymotrypsin after 30 mins [AID328671, Type: Literature]
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45
[SID103192063]
 Activation of caspase 3 after 30 mins [AID328681, Type: Literature]
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46
[SID103192063]
 Growth inhibition of Escherichia coli K12 at 1 mM measured by growth curve [AID325459, Type: Literature]
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47
[SID103192063]
 Growth inhibition of Escherichia coli K10 at 2 to 4 mM measured by growth curve [AID325460, Type: Literature]
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48
[SID103192063]
 Growth inhibition of Salmonella enterica serovar Typhimurium LT2 at 2 to 4 mM measured by growth curve [AID325461, Type: Literature]
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