Bookmark and Share
Spermine (CID 1103) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(40)
 
 
Inactive(263)
 
 
Inconclusive(26)
 
 
Unspecified(141)
 
 
Top Targets:
p450(18)
 
 
 
 
HSD10-like SD..(8)
 
 
 
CXCR4 N(6)
 
 
alpha CA I II..(6)
 
 
 
7TM GPCR Srx(6)
 
 
 
 
BioAssay Types:
Confirmatory(243)
 
 
 
 
Literature(197)
 
 
 
 
 
Screening(2)
 
 
BioActivity Types:
Potency(202)
 
 
 
 
IC50(26)
 
 
 
 
 
Ki(24)
 
 
 
EC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 364    Data Row: 470   Total Pages: 24   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103192063]
Ki 0.01Inhibition of human carbonic anhydrase 4 by stopped flow CO2 hydration method [AID496916, Type: Literature]Carbonic anhydrase 4 [gi:115465]
View
2
[SID103192063]
Ki 0.2Inhibition of [3H]spermine transport by the compound was evaluated in ZR-75-1 human breast cancer cells [AID220401, Type: Literature]
View
3
[SID103192063]
Ki 0.28Inhibition of [3H]spermidine transport into MDA-MB-231 (human breast cancer) cells. [AID101790, Type: Literature]
View
4
[SID103192063]
IC50 0.39Compound was tested for inhibitory concentration required to inhibit 50% of [14C]- putrescine uptake. [AID101071, Type: Literature]
View
5
[SID103192063]
Ki 0.65Inhibition of [3H]putrescine transport by the compound was evaluated in T-47D human breast cancer cells [AID210101, Type: Literature]
View
6
[SID103192063]
Ki 0.71Inhibition of human carbonic anhydrase 7 by stopped flow CO2 hydration method [AID496920, Type: Literature]Carbonic anhydrase 7 [gi:1168744]
View
7
[SID103192063]
Ki 0.83Inhibition of human carbonic anhydrase 5B by stopped flow CO2 hydration method [AID496918, Type: Literature]Carbonic anhydrase 5B, mitochondrial [gi:8928041]
View
8
[SID103192063]
Ki 0.84Inhibition of human carbonic anhydrase 5A by stopped flow CO2 hydration method [AID496917, Type: Literature]Carbonic anhydrase 5A, mitochondrial [gi:461680]
View
9
[SID103192063]
Ki 0.86Inhibition of human carbonic anhydrase 14 by stopped flow CO2 hydration method [AID496924, Type: Literature]Carbonic anhydrase 14 [gi:8928036]
View
10
[SID103192063]
Ki 0.92Inhibition of [3H]spermidine transport by the compound was evaluated in T-47D human breast cancer cells [AID210103, Type: Literature]
View
11
[SID103192063]
Ki 0.99Inhibition of human carbonic anhydrase 6 by stopped flow CO2 hydration method [AID496919, Type: Literature]Carbonic anhydrase 6 [gi:116241278]
View
12
[SID103192063]
Ki 1.34Binding affinity to the mouse polyamine transporter on the L1210 cell surface [AID160317, Type: Literature]
View
13
[SID103192063]
ED50 2Effective dose required for binding to lipopolysaccharide using Fluorescence Displacement Assay; Range is ~1-2 uM [AID240418, Type: Literature]
View
14
[SID103192063]
Km 2Michaelis-Menten constant of compound was determined at MDA-MB-231 cell line mediated by polyamine transporter [AID162587, Type: Literature]
View
15
[SID103192063]
Ki 2.1Inhibition of spermidine transport determined in T-47D human breast cancer cells [AID210118, Type: Literature]
View
16
[SID103192063]
Ki 2.7Inhibition of [3H]spermine transport by the compound was evaluated in T-47D human breast cancer cells [AID210105, Type: Literature]
View
17
[SID103192063]
IC50 2.8Ability to displace ethidium bromide from double stranded synthetic Poly (dA-dT) [AID162413, Type: Literature]
View
18
[SID103192063]
IC50 3Concentration required to decrease the fluorescence of the ethidium bromide-calf thymus DNA complex by 50% [AID54446, Type: Literature]
View
19
[SID103192063]
IC50 4.3Ability to displace ethidium bromide from calf thymus DNA [AID54444, Type: Literature]
View
20
[SID90341642]
Potency 4.6109HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: Hit Validation in HTRF [AID624455, Type: confirmatory]dopamine D1 receptor [Homo sapiens] [gi:299681]
View