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Spermidine (CID 1102) - Compound BioActivity Data
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BioActivity Outcomes:
Active(28)
 
 
Inactive(261)
 
 
Inconclusive(25)
 
 
Unspecified(96)
 
 
Top Targets:
p450(18)
 
 
 
HSD10-like SD..(8)
 
 
PLN02808(6)
 
 
7TM GPCR Srx(6)
 
 
 
Menin(4)
 
 
BioAssay Types:
Confirmatory(246)
 
 
 
 
Literature(135)
 
 
 
 
 
Screening(3)
 
 
BioActivity Types:
Potency(205)
 
 
 
 
IC50(25)
 
 
 
 
Ki(16)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 314    Data Row: 410   Total Pages: 9   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103185577]
Km 0.11Michaelis menton constant of compound was determined at MDA-MB-231 cell line mediated by polyamine transporter [AID162587, Type: Literature]
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2
[SID103185577]
Ki 0.112Inhibition of human carbonic anhydrase 4 by stopped flow CO2 hydration method [AID496916, Type: Literature]Carbonic anhydrase 4 [gi:115465]
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3
[SID103185577]
Ki 0.113Inhibition of [3H]spermidine transport into MDA-MB-231 (human breast cancer) cells. [AID101790, Type: Literature]
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4
[SID103185577]
Ki 1Inhibition of human carbonic anhydrase 14 by stopped flow CO2 hydration method [AID496924, Type: Literature]Carbonic anhydrase 14 [gi:8928036]
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5
[SID103185577]
Ki 1.11Inhibition of human carbonic anhydrase 2 by stopped flow CO2 hydration method [AID496914, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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6
[SID103185577]
Ki 1.22Inhibition of human carbonic anhydrase 5A by stopped flow CO2 hydration method [AID496917, Type: Literature]Carbonic anhydrase 5A, mitochondrial [gi:461680]
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7
[SID103185577]
Ki 1.23Inhibition of human carbonic anhydrase 7 by stopped flow CO2 hydration method [AID496920, Type: Literature]Carbonic anhydrase 7 [gi:1168744]
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8
[SID103185577]
Ki 1.37Inhibition of human carbonic anhydrase 9 by stopped flow CO2 hydration method [AID496921, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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9
[SID103185577]
Ki 1.4Inhibition of human carbonic anhydrase 1 by stopped flow CO2 hydration method [AID496913, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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10
[SID103185577]
Ki 1.41Inhibition of human carbonic anhydrase 6 by stopped flow CO2 hydration method [AID496919, Type: Literature]Carbonic anhydrase 6 [gi:116241278]
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11
[SID103185577]
Ki 1.44Inhibition of human carbonic anhydrase 5B by stopped flow CO2 hydration method [AID496918, Type: Literature]Carbonic anhydrase 5B, mitochondrial [gi:8928041]
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12
[SID103185577]
Ki 2.2Binding affinity values for polyamine transporter was determined [AID160318, Type: Literature]
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13
[SID103185577]
Km 2.46Binding affinity towards polyamine transporter on the L1210 cell surface [AID160319, Type: Literature]
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14
[SID103185577]
Km 4.4Inhibition of spermidine transport determined in T-47D human breast cancer cells [AID210120, Type: Literature]
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15
[SID103185577]
Ki 4.4Inhibition of [3H]spermidine transport by the compound was evaluated in T-47D human breast cancer cells [AID210103, Type: Literature]
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16
[SID11111787]
Potency 6.3096qHTS Assay for Identification of Small Molecule Antagonists for Thrombopoietin (TPO) Signaling Pathway [AID918, Type: confirmatory]Thrombopoietin [Homo sapiens] [gi:120660324]
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17
[SID103185577]
Ki 10Inhibition of mouse carbonic anhydrase 15 by stopped flow CO2 hydration method [AID496925, Type: Literature]Carbonic anhydrase 15 [gi:30580362]
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18
[SID90340561]
Potency 10.6213qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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19
[SID103185577]
Ki 11.5Inhibition of human carbonic anhydrase 3 by stopped flow CO2 hydration method [AID496915, Type: Literature]Carbonic anhydrase 3 [gi:134047703]
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20
[SID103185577]
Ki 11.6Inhibition of mouse carbonic anhydrase 13 by stopped flow CO2 hydration method [AID496923, Type: Literature]Carbonic anhydrase 13 [gi:30580372]
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21
[SID11113819]
Potency 12.5893qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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22
[SID103185577]
Ki 44.1Inhibition of human carbonic anhydrase 12 by stopped flow CO2 hydration method [AID496922, Type: Literature]Carbonic anhydrase 12 [gi:5915866]
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23
[SID11113819]
Cytochrome panel assay with activity outcomes [AID1851_5, Type: other]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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24
[SID11113819]
Cytochrome panel assay with activity outcomes [AID1851_4, Type: other]cytochrome P450 1A2 [Homo sapiens] [gi:73915100]
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25
[SID103185577]
Displacement of [14C]-spermidine from polyamine transporter in human DU145 cells at 1 to 100 uM after 10 mins [AID704415, Type: Literature]
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26
[SID103185577]
Metabolic stability of the compound in human DU145 cells assessed as metabolites-mediated cell toxicity at 10 uM after 48 hrs by MTT assay in presence of bovine serum amine oxidase [AID704417, Type: Literature]
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27
[SID46392889]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Spermidine/putrescine-binding Protein Complexed With Spermidine (monomer Form) [gi:157833547]
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28
[SID11113819]
p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450 1A2 [Homo sapiens] [gi:73915100]
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29
[SID103185577]
IC50 98DNA binding affinity (conc to decrease the fluorescence of the ethidium bromide-DNA complex by 50%) [AID54447, Type: Literature]
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30
[SID103185577]
IC50 100Growth inhibitory activity against L1210 cells (48h) [AID98715, Type: Literature]
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31
[SID103185577]
IC50 100Growth inhibitory activity against L1210 cells (96h) [AID98716, Type: Literature]
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32
[SID103185577]
IC50 100Inhibition of cell growth in CHO-MG cells in the presence of DFMO [AID259076, Type: Literature]
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33
[SID103185577]
IC50 100Cytotoxicity against mouse L1210 ATCC CCL 219 cells after 48 hrs by MTT assay [AID343351, Type: Literature]
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34
[SID103185577]
IC50 100Cytotoxicity against CHO cells after 48 hrs by MTT assay [AID343352, Type: Literature]
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35
[SID103185577]
IC50 100Cytotoxicity against polyamine transport-deficient mutant CHO cells after 48 hrs by MTT assay [AID343353, Type: Literature]
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36
[SID103185577]
IC50 100Concentration required to produce a 50% reduction in the uptake of [3H]TdR, by F98 glioma cells [AID68930, Type: Literature]
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37
[SID103185577]
IC50 100In Vitro Toxicity measured as the conc. required for 50% reduction in SRBabsorbance by F98 glioma cells [AID68931, Type: Literature]
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38
[SID103185577]
IC50 100Ability to inhibit 50% growth of HeLa cells [AID86842, Type: Literature]
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39
[SID103185577]
IC50 105Concentration required to decrease the fluorescence of the ethidium bromide-calf thymus DNA complex by 50% [AID54446, Type: Literature]
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40
[SID103185577]
IC50 110Ability to displace ethidium bromide from double stranded synthetic Poly (dA-dT) [AID162413, Type: Literature]
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41
[SID103185577]
IC50 130Ability to displace ethidium bromide from calf thymus DNA [AID54444, Type: Literature]
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42
[SID103185577]
Km 151Activity of mouse recombinant SSAT expressed in Escherichia coli strain BL21(DE3) [AID704424, Type: Literature]Sulfate anion transporter 1 [gi:20140013]
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43
[SID103185577]
IC50 175Binding of compound to calf thymus DNA was determined by an ethidium bromide displacement assay [AID46156, Type: Literature]
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44
[SID103185577]
IC50 300Ability to displace ethidium bromide from double stranded synthetic poly (dG-dC) [AID162553, Type: Literature]
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45
[SID103185577]
IC50 500Inhibition of bovine calmodulin-activated cAMP dependent phosphodiesterase [AID259074, Type: Literature]Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [gi:544050]
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46
[SID103185577]
IC50 500Inhibition of bovine calmodulin-activated cAMP dependent phosphodiesterase [AID259074, Type: Literature]Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [gi:544051]
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47
[SID103185577]
IC50 1500Ability to cause aggregation of purified HeLa cell DNA [AID87901, Type: Literature]
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48
[SID103185577]
Percentage of putrescine (after 48 hr exposure to 100 uM) in L1210 cells. [AID96497, Type: Literature]
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49
[SID103185577]
Percentage of putrescine after 48 hr exposure to the compound (500 uM ) in L1210 cells [AID96510, Type: Literature]
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50
[SID103185577]
Percentage of spermine (after 48 hr exposure to 100 uM) in L1210 cells. [AID96517, Type: Literature]
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