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Spermidine (CID 1102) - Compound BioActivity Data
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BioActivity Outcomes:
Active(30)
 
 
Inactive(262)
 
 
Inconclusive(25)
 
 
Unspecified(96)
 
 
Top Targets:
p450(18)
 
 
 
HSD10-like SD..(8)
 
 
7TM GPCR Srx(6)
 
 
 
PLN02808(6)
 
 
PLDc mTdp1 2(4)
 
 
BioAssay Types:
Confirmatory(247)
 
 
 
 
Literature(138)
 
 
 
 
 
Screening(3)
 
 
BioActivity Types:
Potency(206)
 
 
 
 
IC50(25)
 
 
 
 
Ki(16)
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 317    Data Row: 413   Total Pages: 21   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103185577]
Km 0.11Michaelis-Menten constant of compound was determined at MDA-MB-231 cell line mediated by polyamine transporter [AID162587, Type: Literature]
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2
[SID103185577]
Ki 0.112Inhibition of human carbonic anhydrase 4 by stopped flow CO2 hydration method [AID496916, Type: Literature]Carbonic anhydrase 4 [gi:115465]
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3
[SID103185577]
Ki 0.113Inhibition of [3H]spermidine transport into MDA-MB-231 (human breast cancer) cells. [AID101790, Type: Literature]
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4
[SID103185577]
Ki 1Inhibition of human carbonic anhydrase 14 by stopped flow CO2 hydration method [AID496924, Type: Literature]Carbonic anhydrase 14 [gi:8928036]
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5
[SID103185577]
Ki 1.11Inhibition of human carbonic anhydrase 2 by stopped flow CO2 hydration method [AID496914, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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6
[SID103185577]
Ki 1.22Inhibition of human carbonic anhydrase 5A by stopped flow CO2 hydration method [AID496917, Type: Literature]Carbonic anhydrase 5A, mitochondrial [gi:461680]
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7
[SID103185577]
Ki 1.23Inhibition of human carbonic anhydrase 7 by stopped flow CO2 hydration method [AID496920, Type: Literature]Carbonic anhydrase 7 [gi:1168744]
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8
[SID103185577]
Ki 1.37Inhibition of human carbonic anhydrase 9 by stopped flow CO2 hydration method [AID496921, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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9
[SID103185577]
Ki 1.4Inhibition of human carbonic anhydrase 1 by stopped flow CO2 hydration method [AID496913, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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10
[SID103185577]
Ki 1.41Inhibition of human carbonic anhydrase 6 by stopped flow CO2 hydration method [AID496919, Type: Literature]Carbonic anhydrase 6 [gi:116241278]
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11
[SID103185577]
Ki 1.44Inhibition of human carbonic anhydrase 5B by stopped flow CO2 hydration method [AID496918, Type: Literature]Carbonic anhydrase 5B, mitochondrial [gi:8928041]
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12
[SID103185577]
Ki 2.2Binding affinity values for polyamine transporter was determined [AID160318, Type: Literature]
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13
[SID103185577]
Km 2.46Binding affinity towards polyamine transporter on the L1210 cell surface [AID160319, Type: Literature]
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14
[SID46392889]
Kd 3.2Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Spermidine/putrescine-binding Protein Complexed With Spermidine (monomer Form) [gi:157833547]
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15
[SID103185577]
Km 4.4Inhibition of spermidine transport determined in T-47D human breast cancer cells [AID210120, Type: Literature]
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16
[SID103185577]
Ki 4.4Inhibition of [3H]spermidine transport by the compound was evaluated in T-47D human breast cancer cells [AID210103, Type: Literature]
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17
[SID11111787]
Potency 6.3096qHTS Assay for Identification of Small Molecule Antagonists for Thrombopoietin (TPO) Signaling Pathway [AID918, Type: confirmatory]Thrombopoietin [Homo sapiens] [gi:120660324]
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18
[SID103185577]
Ki 10Inhibition of mouse carbonic anhydrase 15 by stopped flow CO2 hydration method [AID496925, Type: Literature]Carbonic anhydrase 15 [gi:30580362]
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19
[SID90340561]
Potency 10.6213qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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20
[SID103185577]
Ki 11.5Inhibition of human carbonic anhydrase 3 by stopped flow CO2 hydration method [AID496915, Type: Literature]Carbonic anhydrase 3 [gi:134047703]
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