CHEMBL1812859 (CID 10902085) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(4)
 
 
Unspecified(3)
 
 
Top Targets:
Esterase lipa..(7)
 
 
 
BioAssay Types:
Literature(7)
 
 
 
BioActivity Types:
Ki(6)
 
 
 
SAR
Target summary
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 7    Data Row: 7   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID134447799]
Ki 0.00084Inhibition of human liver carboxylesterase1 using o-nitrophenyl acetate as substrate after 5 mins by spectrophotometry [AID612130, Type: Literature]Liver carboxylesterase 1 [gi:119576]
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2
[SID134447799]
Ki 0.00084Inhibition of human liver carboxylesterase1 using o-nitrophenyl acetate as substrate after 5 mins by spectrophotometry [AID612130, Type: Literature]Liver carboxylesterase 1 [gi:119576]
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3
[SID134447799]
Ki 0.0057Inhibition of human intestinal carboxylesterase using o-nitrophenyl acetate as substrate after 5 mins by spectrophotometry [AID612131, Type: Literature]Cocaine esterase [gi:46576349]
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4
[SID134447799]
Ki 0.009Inhibition of rabbit liver carboxylesterase using o-nitrophenyl acetate as substrate after for 5 mins by spectrophotometry [AID612132, Type: Literature]Liver carboxylesterase 1 [gi:51338757]
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5
[SID134447799]
Ki 0.0245Inhibition of human intestinal carboxylesterase assessed as hydrolysis of CPT-11 after 5 mins by HPLC [AID612137, Type: Literature]Cocaine esterase [gi:46576349]
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6
[SID134447799]
Ki 100Inhibition of human acetylcholinesterase using acetylthiocholine as substrate by spectrophotometry [AID612134, Type: Literature]Acetylcholinesterase [gi:113037]
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7
[SID134447799]
Ki 100Inhibition of human butyrylcholinesterase using butyrylthiocholine as substrate by spectrophotometry [AID612135, Type: Literature]Cholinesterase [gi:116353]
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8
[SID134447799]
 Inhibition of intestinal carboxylesterase in human U373MG cells using 4-methylumbelliferone acetate as substrate at 10 uM after 1 hrs pre-incubation by fluorimetry [AID612138, Type: Literature]Cocaine esterase [gi:46576349]
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