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BAS 07162071 (CID 1088439) - Compound BioActivity Data
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BioActivity Outcomes:
Active(12)
 
 
Inactive(205)
 
 
Inconclusive(2)
 
 
Unspecified(3)
 
 
Top Targets:
7TM GPCR Srsx(10)
 
 
NACHT(9)
 
 
 
7TM GPCR Srx(7)
 
 
 
RasGEF(4)
 
 
Anthrax-tox M(3)
 
 
BioAssay Types:
Screening(149)
 
 
 
Confirmatory(47)
 
 
 
 
Literature(19)
 
 
 
 
BioActivity Types:
Potency(34)
 
 
 
IC50(17)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 205    Data Row: 222   Total Pages: 12   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID160671893]
IC50 0.09Inhibition of NOD-1 mediated NFkappaB activation in HEK293T cells assessed as inhibition of gamma-tri-DAP-induced luciferase activity after 14 hrs by reporter gene assay [AID655843, Type: Literature]Nucleotide-binding oligomerization domain-containing protein 1 [gi:20137579]
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2
[SID85256232]
IC50_Mean 0.094SAR analysis of compounds that inhibit NOD1 revised [AID2333, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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3
[SID85248349]
IC50_Mean 0.485SAR analysis of compounds that inhibit NOD1 revised [AID2333, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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4
[SID85248349]
IC50 1.077SAR analysis of NF-kB dependent luciferase using DAP as an inducer [AID2264, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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5
[SID160671893]
IC50 1.2Inhibition of human ALDH3A1-mediated benzaldehyde oxidation preincubated for 1 min followed by substrate addition by spectrophotometric analysis [AID1068474, Type: Literature]Aldehyde dehydrogenase, dimeric NADP-preferring [gi:311033473]
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6
[SID85248349]
IC50_Mean 1.46SAR analysis of GM-Tri-DAP induced IL-8 secretion in MCF-7/NOD1 cells [AID2250, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
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7
[SID85256232]
IC50_Mean 19.7SAR analysis of compounds that inhibit NOD2 revised [AID2334, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 isoform 1 [Homo sapiens] [gi:11545912]
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8
[SID160671893]
IC50 19.9Inhibition of NOD-2 mediated NFkappaB activation in HEK293T cells assessed as inhibition of MDP-induced luciferase activity after 14 hrs by reporter gene assay [AID655844, Type: Literature]Nucleotide-binding oligomerization domain-containing protein 2 [gi:20137973]
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9
[SID99495605]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 5 (CHRM5) [AID624040, Type: screening]muscarinic acetylcholine receptor M5 [Homo sapiens] [gi:7108336]
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10
[SID99495605]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 4 (CHRM4) [AID624125, Type: screening]muscarinic acetylcholine receptor M4 [Homo sapiens] [gi:52426748]
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11
[SID99495605]
Luminescence-based cell-based primary high throughput screening assay for inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1): repression of SF-1 (NR5A1) activated StAR promoter by full-length DAX-1 [AID652010, Type: screening]nuclear receptor subfamily 0 group B member 1 [Homo sapiens] [gi:5016090]
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12
[SID99495605]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]muscarinic acetylcholine receptor M1 [Homo sapiens] [gi:37622910]
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13
[SID160671893]
IC50 20Inhibition of TNFalpha-induced NFkappaB activation in HEK293T cells after 14 hrs by luciferase reporter gene assay [AID655845, Type: Literature]
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14
[SID160671893]
Cytotoxicity against HEK293T cells at 20 uM by alamar blue assay [AID655846, Type: Literature]
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15
[SID160671893]
Activation of human ALDH1A1 using propionaldehyde as substrate at 100 uM preincubated for 1 min followed by substrate addition by spectrophotometric analysis [AID1068464, Type: Literature]Retinal dehydrogenase 1 [gi:118495]
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16
[SID85248349]
IC50_Mean 5SAR analysis of muramyl dipeptide (MDP) induced IL-8 secretion in MCF-7/NOD2 cells. [AID2260, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
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17
[SID85248349]
IC50_Mean 5SAR analysis of tumor necrosis factor alpha (TNF-alpha) induced IL-8 secretion in MCF-7/NOD1 cells. [AID2245, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
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18
[SID85248349]
IC50_Mean 20SAR analysis of compounds that are cytotoxic to HEK293 revised [AID2335, Type: confirmatory]
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19
[SID85256232]
IC50_Mean 20SAR analysis of compounds that are cytotoxic to HEK293 revised [AID2335, Type: confirmatory]
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20
[SID85248349]
IC50_Mean 20SAR analysis of inhibitors of TNFa specific NF-kB induction revised [AID2337, Type: confirmatory]tumor necrosis factor [Homo sapiens] [gi:25952111]
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