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ML130 (CID 1088438) - Compound BioActivity Data
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BioActivity Outcomes:
Probe(1)
 
 
Active(30)
 
 
Inactive(553)
 
 
Inconclusive(10)
 
 
Unspecified(38)
 
 
Top Targets:
7tm 4(37)
 
 
 
NACHT(21)
 
 
 
 
 
Chemokine CXC(12)
 
 
 
TRP 2(10)
 
 
 
TNF(6)
 
 
BioAssay Types:
Screening(379)
 
 
 
 
Confirmatory(189)
 
 
 
 
 
Literature(51)
 
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(121)
 
 
 
 
 
IC50(64)
 
 
 
 
EC50(5)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 574    Data Row: 632   Total Pages: 32   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85248360]
Summary assay for the identification of compounds that inhibit NOD1 [AID1575, Type: summary]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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2
[SID85176678]
IC50_Mean 0.257SAR analysis of compounds that inhibit NOD1 - Set 3 [AID2798, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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3
[SID47203507]
EC50 0.46uHTS luminescence assay for the identification of compounds that inhibit NOD1 [AID1578, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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4
[SID85248360]
IC50 0.5507SAR analysis of GM-Tri-DAP induced IL-8 secretion in MCF-7/NOD1 cells - Set 2 [AID2505, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
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5
[SID160671861]
IC50 0.56Inhibition of NOD-1 mediated NFkappaB activation in HEK293T cells assessed as inhibition of gamma-tri-DAP-induced luciferase activity after 14 hrs by reporter gene assay [AID655843, Type: Literature]Nucleotide-binding oligomerization domain-containing protein 1 [gi:20137579]
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6
[SID85176678]
IC50_Mean 0.56SAR analysis of compounds that inhibit NOD1 revised [AID2333, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
View
7
[SID85176678]
IC50 0.596SAR analysis of GM-Tri-DAP induced IL-8 secretion in MCF-7/NOD1 cells - Set 2 [AID2505, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
View
8
[SID85176678]
IC50_Mean 0.62SAR analysis of GM-Tri-DAP induced IL-8 secretion in MCF-7/NOD1 cells [AID2250, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
View
9
[SID85248360]
IC50_Mean 0.706SAR analysis of compounds that inhibit NOD1 revised [AID2333, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
View
10
[SID85248360]
IC50_Mean 0.72SAR analysis of compounds that inhibit NOD1 - Set 2 [AID2466, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
View
11
[SID85248360]
IC50_Mean 0.81SAR analysis of GM-Tri-DAP induced IL-8 secretion in MCF-7/NOD1 cells [AID2250, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
View
12
[SID85176678]
IC50 0.9724SAR analysis of NF-kB dependent luciferase using DAP as an inducer [AID2264, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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13
[SID85176678]
IC50 17.25SAR analysis of Muramyl dipeptide (MDP) induced IL-8 secretion in MCF-7/NOD2 cells - Set 2 [AID2503, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
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14
[SID47203507]
EC50 17.78Confirmation dose response assay for compounds that inhibit transient receptor potential cation channel C6 (TRPC6). [AID2696, Type: confirmatory]short transient receptor potential channel 6 isoform 1 [Mus musculus] [gi:160333370]
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15
[SID85248360]
IC50 18.77SAR analysis of Muramyl dipeptide (MDP) induced IL-8 secretion in MCF-7/NOD2 cells - Set 2 [AID2503, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
View
16
[SID47203507]
Potency 50.1187qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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17
[SID160671861]
Inhibition of NOD-1 in human MCF7 cells assessed as inhibition of gamma-tri-DAP-induced IL8 secretion at 0.25 to 5 uM by ELISA [AID655849, Type: Literature]Nucleotide-binding oligomerization domain-containing protein 1 [gi:20137579]
View
18
[SID160671861]
Inhibition of NOD-1 mediated NFkappaB activation in HEK293T cells assessed as inhibition of gamma-tri-DAP-induced luciferase activity at 0.25 to 25 uM by reporter gene assay [AID655852, Type: Literature]Nucleotide-binding oligomerization domain-containing protein 1 [gi:20137579]
View
19
[SID47203507]
Primary cell-based high-throughput screening assay for identification of compounds that potentiate/activate regulator of G-protein signaling 4 (RGS4) [AID463111, Type: screening]regulator of G-protein signaling 4 isoform 2 [Homo sapiens] [gi:5032039]
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20
[SID47203507]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]muscarinic acetylcholine receptor M1 [Homo sapiens] [gi:37622910]
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