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ML130 (CID 1088438) - Compound BioActivity Data
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BioActivity Outcomes:
Probe(1)
 
 
Active(30)
 
 
Inactive(548)
 
 
Inconclusive(8)
 
 
Unspecified(38)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
 
NACHT(21)
 
 
 
 
 
7TM GPCR Srsx(15)
 
 
Chemokine CXC(12)
 
 
 
TRP 2(10)
 
 
 
BioAssay Types:
Screening(378)
 
 
 
 
Confirmatory(189)
 
 
 
 
 
Literature(45)
 
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(121)
 
 
 
 
 
IC50(64)
 
 
 
 
EC50(5)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 573    Data Row: 625   Total Pages: 13   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85248360]
Summary assay for the identification of compounds that inhibit NOD1 [AID1575, Type: summary]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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2
[SID85176678]
IC50_Mean 0.257SAR analysis of compounds that inhibit NOD1 - Set 3 [AID2798, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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3
[SID47203507]
EC50 0.46uHTS luminescence assay for the identification of compounds that inhibit NOD1 [AID1578, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
View
4
[SID85248360]
IC50 0.5507SAR analysis of GM-Tri-DAP induced IL-8 secretion in MCF-7/NOD1 cells - Set 2 [AID2505, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
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5
[SID85176678]
IC50_Mean 0.56SAR analysis of compounds that inhibit NOD1 revised [AID2333, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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6
[SID160671861]
IC50 0.56Inhibition of NOD-1 mediated NFkappaB activation in HEK293T cells assessed as inhibition of gamma-tri-DAP-induced luciferase activity after 14 hrs by reporter gene assay [AID655843, Type: Literature]Nucleotide-binding oligomerization domain-containing protein 1 [gi:20137579]
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7
[SID85176678]
IC50 0.596SAR analysis of GM-Tri-DAP induced IL-8 secretion in MCF-7/NOD1 cells - Set 2 [AID2505, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
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8
[SID85176678]
IC50_Mean 0.62SAR analysis of GM-Tri-DAP induced IL-8 secretion in MCF-7/NOD1 cells [AID2250, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
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9
[SID85248360]
IC50_Mean 0.706SAR analysis of compounds that inhibit NOD1 revised [AID2333, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
View
10
[SID85248360]
IC50_Mean 0.72SAR analysis of compounds that inhibit NOD1 - Set 2 [AID2466, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
View
11
[SID85248360]
IC50_Mean 0.81SAR analysis of GM-Tri-DAP induced IL-8 secretion in MCF-7/NOD1 cells [AID2250, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
View
12
[SID85176678]
IC50 0.9724SAR analysis of NF-kB dependent luciferase using DAP as an inducer [AID2264, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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13
[SID85176678]
IC50 17.25SAR analysis of Muramyl dipeptide (MDP) induced IL-8 secretion in MCF-7/NOD2 cells - Set 2 [AID2503, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
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14
[SID47203507]
EC50 17.78Confirmation dose response assay for compounds that inhibit transient receptor potential cation channel C6 (TRPC6). [AID2696, Type: confirmatory]short transient receptor potential channel 6 isoform 1 [Mus musculus] [gi:160333370]
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15
[SID85248360]
IC50 18.77SAR analysis of Muramyl dipeptide (MDP) induced IL-8 secretion in MCF-7/NOD2 cells - Set 2 [AID2503, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
View
16
[SID47203507]
Potency 50.1187qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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17
[SID47203507]
Confirmatory screen for identification of compounds that inhibit transient receptor potential cation channel C6 (TRPC6) [AID488960, Type: screening]short transient receptor potential channel 6 isoform 1 [Mus musculus] [gi:160333370]
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18
[SID47203507]
High throughput screening of inhibitors of transient receptor potential cation channel C6 (TRPC6) [AID2553, Type: screening]short transient receptor potential channel 6 isoform 1 [Mus musculus] [gi:160333370]
View
19
[SID47203507]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]muscarinic acetylcholine receptor M1 [Homo sapiens] [gi:37622910]
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20
[SID47203507]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of human platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (PAFAH1B2) [AID492953, Type: screening]platelet-activating factor acetylhydrolase IB subunit beta isoform b [Homo sapiens] [gi:296080766]
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21
[SID47203507]
Fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of human platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (PAFAH1B2) [AID493034, Type: screening]platelet-activating factor acetylhydrolase IB subunit beta isoform b [Homo sapiens] [gi:296080766]
View
22
[SID160671861]
Inhibition of NOD-1 mediated NFkappaB activation in HEK293T cells assessed as inhibition of gamma-tri-DAP-induced luciferase activity at 0.25 to 25 uM by reporter gene assay [AID655852, Type: Literature]Nucleotide-binding oligomerization domain-containing protein 1 [gi:20137579]
View
23
[SID160671861]
Inhibition of NOD-1 in human MCF7 cells assessed as inhibition of gamma-tri-DAP-induced IL8 secretion at 0.25 to 5 uM by ELISA [AID655849, Type: Literature]Nucleotide-binding oligomerization domain-containing protein 1 [gi:20137579]
View
24
[SID47203507]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 4 (CHRM4) [AID624125, Type: screening]muscarinic acetylcholine receptor M4 [Homo sapiens] [gi:52426748]
View
25
[SID47203507]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 5 (CHRM5) [AID624040, Type: screening]muscarinic acetylcholine receptor M5 [Homo sapiens] [gi:7108336]
View
26
[SID47203507]
EC50 uHTS luminescence assay for the identification of compounds that inhibit NOD2 [AID1566, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
View
27
[SID47203507]
Validation assay for identification of compounds that activate the regulator of G-protein signaling 4 (RGS4) [AID602282, Type: screening]regulator of G-protein signaling 4 isoform 2 [Homo sapiens] [gi:5032039]
View
28
[SID47203507]
Primary cell-based high-throughput screening assay for identification of compounds that potentiate/activate regulator of G-protein signaling 4 (RGS4) [AID463111, Type: screening]regulator of G-protein signaling 4 isoform 2 [Homo sapiens] [gi:5032039]
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29
[SID47203507]
Second counter screen for compounds that inhibit transient receptor potential cation channel C6 (TRPC6) [AID2779, Type: screening]
View
30
[SID47203507]
Parallel artificial membrane permeability assay at pH 7.4 [AID624339, Type: other]
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31
[SID47203507]
Counter screen for identification of compounds that activate the regulator of G-protein signaling 4 (RGS4): Non-induced cells with the primary screen assay [AID602283, Type: screening]
View
32
[SID160671861]
IC50 20Inhibition of TNFalpha-induced NFkappaB activation in HEK293T cells after 14 hrs by luciferase reporter gene assay [AID655845, Type: Literature]
View
33
[SID160671861]
IC50 20Inhibition of NOD-2 mediated NFkappaB activation in HEK293T cells assessed as inhibition of MDP-induced luciferase activity after 14 hrs by reporter gene assay [AID655844, Type: Literature]Nucleotide-binding oligomerization domain-containing protein 2 [gi:20137973]
View
34
[SID160671861]
LD50 50Cytotoxicity against human Fa2N-4 cells after 24 hrs by ATP-lite assay [AID655855, Type: Literature]
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35
[SID160671861]
Solubility of the compound at pH 5 [AID655856, Type: Literature]
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36
[SID160671861]
Solubility of the compound at pH 6.2 [AID655857, Type: Literature]
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37
[SID160671861]
Solubility of the compound at pH 7.4 [AID655858, Type: Literature]
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38
[SID160671861]
Effective Permeability of the compound at 50 uM at pH 5 after 30 mins by PAMPA assay [AID655859, Type: Literature]
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39
[SID160671861]
Effective Permeability of the compound at 50 uM at pH 6.2 after 30 mins by PAMPA assay [AID655860, Type: Literature]
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40
[SID160671861]
Effective Permeability of the compound at 50 uM at pH 7.4 after 30 mins by PAMPA assay [AID655861, Type: Literature]
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41
[SID160671861]
Plasma protein binding in human at 1 uM after 4 hrs [AID655862, Type: Literature]
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42
[SID160671861]
Plasma protein binding in human at 10 uM after 4 hrs [AID655863, Type: Literature]
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43
[SID160671861]
Plasma protein binding in mouse at 1 uM after 4 hrs [AID655864, Type: Literature]
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44
[SID160671861]
Plasma protein binding in mouse at 10 uM after 4 hrs [AID655865, Type: Literature]
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45
[SID160671861]
Metabolic stability in human plasma assessed as compound remaining at 1 uM after 180 mins [AID655866, Type: Literature]
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46
[SID160671861]
Metabolic stability in mouse plasma assessed as compound remaining at 1 uM after 180 mins [AID655867, Type: Literature]
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47
[SID160671861]
Metabolic stability in human liver microsomes assessed as compound remaining at 1 uM preincubated for 10 mins measured after 60 mins [AID655868, Type: Literature]
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48
[SID160671861]
Metabolic stability in mouse liver microsomes assessed as compound remaining at 1 uM preincubated for 10 mins measured after 60 mins [AID655869, Type: Literature]
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49
[SID160671861]
Plasma concentration in mouse at 15 mg/kg, ip at 20 mins [AID655870, Type: Literature]
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50
[SID160671861]
Plasma concentration in mouse at 30 mg/kg, ip at 20 mins [AID655871, Type: Literature]
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