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GSK 8470 (CID 10883540) - Compound BioActivity Data
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BioActivity Outcomes:
Active(7)
 
 
Inactive(1)
 
 
Unspecified(4)
 
 
Top Targets:
NR LBD Lrh-1(6)
 
 
 
NR LBD SF-1(5)
 
 
 
 
BioAssay Types:
Literature(11)
 
 
 
Summary(1)
 
 
BioActivity Types:
EC50(5)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 12    Data Row: 12   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103501294]
EC50 0.054Binding affinity to human SF1 by FRET-based peptide recruitment assay [AID271722, Type: Literature]Steroidogenic factor 1 [gi:3121738]
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2
[SID103501294]
EC50 0.15849Agonist activity at human SF-1 assessed as DAX1 1-23 peptide recruitment by TR-FRET assay relative to control [AID593529, Type: Literature]Steroidogenic factor 1 [gi:3121738]
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3
[SID103501294]
EC50 0.43Binding affinity to human LRH1 by FRET-based peptide recruitment assay [AID271721, Type: Literature]Nuclear receptor subfamily 5 group A member 2 [gi:7676156]
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4
[SID103501294]
EC50 0.63096Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control [AID593528, Type: Literature]Nuclear receptor subfamily 5 group A member 2 [gi:7676156]
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5
[SID103501294]
EC50 1Agonist activity at human LRH1 expressed in CV1 cells assessed as SHP reporter gene transactivation by luciferase assay [AID271717, Type: Literature]Nuclear receptor subfamily 5 group A member 2 [gi:7676156]
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6
[SID103501294]
Agonist activity at human LRH1 assessed as induction of SHP mRNA expression in human primary hepatocytes at 10 uM [AID271718, Type: Literature]Nuclear receptor subfamily 5 group A member 2 [gi:7676156]
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7
[SID103501294]
Agonist activity at human LRH1 assessed as induction of SHP mRNA expression in HepG2 cells at 10 uM [AID271719, Type: Literature]Nuclear receptor subfamily 5 group A member 2 [gi:7676156]
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8
[SID103501294]
Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay [AID593526, Type: Literature]Nuclear receptor subfamily 5 group A member 2 [gi:7676156]
View
9
[SID103501294]
Binding affinity to human SF1 relative to 3-Hexyl-1-phenylamino-2-phenyl-cis-bicyclo[3.3.0]oct-2-ene1 by FRET-based peptide recruitment assay [AID271716, Type: Literature]Steroidogenic factor 1 [gi:3121738]
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10
[SID103501294]
Agonist activity at human SF-1 assessed as DAX1 1-23 peptide recruitment by TR-FRET assay [AID593527, Type: Literature]Steroidogenic factor 1 [gi:3121738]
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11
[SID103501294]
Stability in 1 M acetic acid [AID271720, Type: Literature]
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12
[SID74380218]
Summary of probe development efforts to identify activators of the nuclear receptor Steroidogenic Factor 1 (SF-1). [AID1951, Type: summary]steroidogenic factor 1 [Homo sapiens] [gi:20070193]
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