epicatechin gallate (CID 107905) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(45)
 
 
Inactive(29)
 
 
Inconclusive(2)
 
 
Unspecified(50)
 
 
Top Targets:
HIF-1a CTAD(7)
 
 
 
7TM GPCR Srx(4)
 
 
 
PAS(4)
 
 
 
ABCC MRP doma..(3)
 
 
ALBUMIN(1)
 
 
BioAssay Types:
Literature(101)
 
 
 
 
 
Screening(3)
 
 
BioActivity Types:
IC50(25)
 
 
 
Ki(3)
 
 
EC50(1)
 
 
Kd(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 126    Data Row: 126   Total Pages: 3   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103215553]
Ki 0.016Inhibition of Plasmodium falciparum ENR in presence of triclosan [AID277587, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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2
[SID103215553]
IC50 0.036Binding affinity to opiate receptor [AID311289, Type: Literature]
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3
[SID103215553]
Ki 0.102Inhibition of Plasmodium falciparum ENR using crotonyl-CoA substrate [AID277586, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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4
[SID103215553]
IC50 0.18Inhibition of yeast G6PD [AID319369, Type: Literature]Glucose-6-phosphate 1-dehydrogenase [gi:120734]
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5
[SID103215553]
IC50 0.2Inhibition of FabI [AID265759, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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6
[SID103215553]
IC50 0.21Inhibition of 6PGD [AID319370, Type: Literature]
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7
[SID103215553]
Ki 0.291Inhibition of Plasmodium falciparum ENR using NADH substrate [AID277585, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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8
[SID103215553]
IC50 0.4Inhibition of FabZ [AID265758, Type: Literature]Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein) [gi:74844869]
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9
[SID103215553]
IC50 0.5Inhibition of Plasmodium falciparum ENR [AID277583, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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10
[SID103215553]
IC50 0.76Inhibition of polymerization in wild type HIV-1 RT with poly rC/dG12-18 template primer and [3H]dGTP [AID83435, Type: Literature]Reverse transcriptase/RNaseH [gi:82310930]
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11
[SID103215553]
IC50 1Inhibition of FabG [AID265760, Type: Literature]3-oxoacyl-acyl-carrier protein reductase precursor [gi:75020671]
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12
[SID103215553]
IC50 1.47Inhibition of p38alpha after 1 hr by ELISA [AID566611, Type: Literature]
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13
[SID103215553]
IC50 1.5Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by spectrophotometry [AID650645, Type: Literature]
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14
[SID103215553]
IC50 5.4Inhibition of lipid peroxidation in Sprague-Dawley rat heart mitochondria assessed as inhibition of FeSO4-induced malondialdehyde formation [AID398697, Type: other]
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15
[SID103215553]
IC50 8.4Inhibition of lipid peroxidation in Sprague-Dawley rat heart mitochondria assessed as inhibition of FeSO4-induced oxygen consumption [AID398696, Type: other]
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16
[SID103215553]
IC50 10Inhibition of Escherichia coli ENR [AID277584, Type: Literature]
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17
[SID103215553]
IC50 10Inhibition of MET kinase [AID437510, Type: Literature]
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18
[SID103215553]
IC50 10.8Inhibition of IDH [AID319371, Type: Literature]
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19
[SID103215553]
IC50 11.3Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 [AID265762, Type: Literature]
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20
[SID103215553]
IC50 25Inhibition of G6PD-mediated NADPH production in mouse 3T3-L1 cells [AID319372, Type: Literature]
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21
[SID103215553]
MIC 25Antibacterial activity against Escherichia coli [AID310895, Type: Literature]
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22
[SID103215553]
IC50 28Inhibitory activity towards acetylcholine esterase (AChE) [AID240567, Type: Literature]
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23
[SID103215553]
Kd 36Displacement of fluorescent quercetin from Escherichia coli BL21 (DE3) recombinant DNA gyrase B G24 [AID310889, Type: Literature]
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24
[SID103215553]
IC50 40Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 [AID265761, Type: Literature]
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25
[SID103215553]
 Growth inhibition of human Caco-2 cells at 25 uM after 6 days [AID318322, Type: Literature]
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26
[SID103215553]
 Induction of VEGF mRNA expression in human T47D cells under normoxic condition at 100 uM after 16 hrs by RT-PCR [AID333765, Type: Literature]
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27
[SID103215553]
 Induction of GLUT1 mRNA expression in human T47D cells under normoxic condition at 100 uM after 16 hrs by RT-PCR [AID333766, Type: Literature]
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28
[SID103215553]
 Induction of CDKN1A mRNA expression in human T47D cells under normoxic condition at 100 uM after 16 hrs by RT-PCR [AID333767, Type: Literature]
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29
[SID103215553]
 Inhibition of Escherichia coli DNA gyrase B ATPase activity [AID310890, Type: Literature]
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30
[SID103215553]
 Inhibition of FCepsilonRI expression in human HMC1 cells at 100 uM after 72 hrs by flow cytometry [AID474215, Type: Literature]
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31
[SID103215553]
 Chemical stability in 100 mM phosphate buffer at pH 7.4 at 100 uM after 60 mins by HPLC analysis [AID492403, Type: Literature]
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32
[SID103215553]
 Antimigratory activity against Swiss albino mouse 3T3 cells assessed as increase of cell numbers at 1 uM after 12 hrs by by scratch-wound assay [AID566605, Type: Literature]
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33
[SID103215553]
 Potentiation of oxacillin-induced antistaphylococcal activity against epidemic Staphylococcus aureus isolate 16 at 12.5 ug/mL by CLSI broth microplate assay [AID632948, Type: Literature]
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34
[SID103215553]
 Inhibition of hypoxia-induced increase in HIF1alpha protein in human T47D cells at 100 uM after 4 hrs by western blot analysis [AID333772, Type: Literature]Hypoxia-inducible factor 1-alpha [gi:2498017]
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35
[SID103215553]
 Inhibition of hypoxia-induced increase in HIF1alpha protein in human T47D cells at 100 uM after 4 hrs by western blot analysis [AID333772, Type: Literature]Hypoxia-inducible factor 1-alpha [gi:2498017]
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36
[SID103215553]
 Inhibition of hypoxia-induced increase in HIF1alpha protein in human T47D cells at 100 uM after 4 hrs by western blot analysis [AID333772, Type: Literature]Hypoxia-inducible factor 1-alpha [gi:2498017]
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37
[SID103215553]
 Induction of HIF1alpha protein in human T47D cells under normoxic condition at 100 uM after 4 hrs by western blot analysis [AID333770, Type: Literature]Hypoxia-inducible factor 1-alpha [gi:2498017]
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38
[SID103215553]
 Induction of HIF1alpha protein in human T47D cells under normoxic condition at 100 uM after 4 hrs by western blot analysis [AID333770, Type: Literature]Hypoxia-inducible factor 1-alpha [gi:2498017]
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39
[SID103215553]
 Induction of HIF1alpha protein in human T47D cells under normoxic condition at 100 uM after 4 hrs by western blot analysis [AID333770, Type: Literature]Hypoxia-inducible factor 1-alpha [gi:2498017]
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40
[SID103215553]
 Induction of HIF1alpha protein in human T47D cells under normoxic condition at 100 uM after 4 hrs by western blot analysis in presence of trolox [AID333787, Type: Literature]Hypoxia-inducible factor 1-alpha [gi:2498017]
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41
[SID103215553]
 Induction of HIF1alpha protein in human T47D cells under normoxic condition at 100 uM after 4 hrs by western blot analysis in presence of trolox [AID333787, Type: Literature]Hypoxia-inducible factor 1-alpha [gi:2498017]
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42
[SID103215553]
 Induction of HIF1alpha protein in human T47D cells under normoxic condition at 100 uM after 4 hrs by western blot analysis in presence of trolox [AID333787, Type: Literature]Hypoxia-inducible factor 1-alpha [gi:2498017]
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43
[SID103215553]
 Binding affinity to human serum albumin in 100 mM phosphate buffer at pH 7.4 assessed as formation of biotin-LC-hydrazide labeled protein carbonyls at 100 uM pretreated 60 mins before biotin-LC-hydrazide challenge measured after 60 mins by SDS-PAGE/Western blotting [AID492404, Type: Literature]Serum albumin [gi:113576]
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44
[SID103215553]
 Induction of HIF1beta protein in human T47D cells under normoxic condition at 100 uM after 4 hrs by western blot analysis in presence of 300 uM iron(2) [AID333779, Type: Literature]Aryl hydrocarbon receptor nuclear translocator [gi:114163]
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45
[SID103215553]
 Induction of HIF1beta protein in human T47D cells under normoxic condition at 100 uM after 4 hrs by western blot analysis in presence of 300 uM iron(2) [AID333779, Type: Literature]Aryl hydrocarbon receptor nuclear translocator [gi:114163]
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46
[SID103215553]
 Induction of HIF1beta protein in human T47D cells under normoxic condition at 100 uM after 4 hrs by western blot analysis in presence of ascorbate [AID333786, Type: Literature]Aryl hydrocarbon receptor nuclear translocator [gi:114163]
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47
[SID103215553]
 Induction of HIF1beta protein in human T47D cells under normoxic condition at 100 uM after 4 hrs by western blot analysis in presence of ascorbate [AID333786, Type: Literature]Aryl hydrocarbon receptor nuclear translocator [gi:114163]
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48
[SID103215553]
 Induction of HIF1beta protein in human T47D cells under normoxic condition at 100 uM after 4 hrs by western blot analysis in presence of 150 uM iron(3) [AID333783, Type: Literature]Aryl hydrocarbon receptor nuclear translocator [gi:114163]
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49
[SID103215553]
 Induction of HIF1beta protein in human T47D cells under normoxic condition at 100 uM after 4 hrs by western blot analysis in presence of 150 uM iron(3) [AID333783, Type: Literature]Aryl hydrocarbon receptor nuclear translocator [gi:114163]
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50
[SID103215553]
 Inhibition of hepatocyte growth factor-induced MET phosphorylation in human HCT116 cells at 5 uM after 30 mins by immunoblot [AID437509, Type: Literature]Hepatocyte growth factor receptor [gi:251757497]
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