SMR000297947 (CID 1067700) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Probe(1)
 
 
Active(55)
 
 
Inactive(581)
 
 
Inconclusive(9)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(16)
 
 
Ras like GTPa..(14)
 
 
 
 
alkPPc(10)
 
 
Bcl-2 like(10)
 
 
Rac1 like(10)
 
 
 
BioAssay Types:
Screening(400)
 
 
 
 
Confirmatory(209)
 
 
 
 
 
Literature(5)
 
 
Summary(1)
 
 
BioActivity Types:
Potency(123)
 
 
 
 
 
EC50(41)
 
 
 
IC50(40)
 
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 625    Data Row: 647   Total Pages: 13   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85747738]
 Project utilizing multiplex HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases [AID1772, Type: summary]ras protein [Homo sapiens] [gi:190938]
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2
[SID85747738]
 Project utilizing multiplex HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases [AID1772, Type: summary]ras protein [Homo sapiens] [gi:190938]
View
3
[SID85747738]
 Project utilizing multiplex HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases [AID1772, Type: summary]ras protein [Homo sapiens] [gi:190938]
View
4
[SID85747738]
EC50 0.02SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras wildtype, round 2 [AID588630, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
View
5
[SID85747738]
EC50 0.02SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras wildtype, round 2 [AID588630, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
View
6
[SID85747738]
EC50 0.02SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras wildtype, round 2 [AID588630, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
View
7
[SID85747738]
EC50 0.021SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras activated mutant, round 2 [AID588628, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
View
8
[SID85747738]
EC50 0.021SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras activated mutant, round 2 [AID588628, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
View
9
[SID85747738]
EC50 0.021SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras activated mutant, round 2 [AID588628, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
View
10
[SID85747738]
EC50 0.022SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype, round 2 [AID588631, Type: confirmatory]GTP-binding protein (rab7) [Canis lupus familiaris] [gi:164058]
View
11
[SID24798006]
EC50 0.05627Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype [AID1334, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
View
12
[SID57578339]
EC50 0.0563Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype [AID1334, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
View
13
[SID57578339]
EC50 0.078SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype, round 1 [AID588383, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
View
14
[SID57578339]
EC50 0.078SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype, round 1 [AID588383, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
View
15
[SID57578339]
EC50 0.078SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype, round 1 [AID588383, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
View
16
[SID57578339]
EC50 0.078SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras wildtype, round 1 [AID588388, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
View
17
[SID57578339]
EC50 0.078SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras wildtype, round 1 [AID588388, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
View
18
[SID57578339]
EC50 0.078SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras wildtype, round 1 [AID588388, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
View
19
[SID24798006]
EC50 0.08056Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype [AID1340, Type: confirmatory]Rac1 protein [Homo sapiens] [gi:8574038]
View
20
[SID24798006]
EC50 0.08056Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype [AID1340, Type: confirmatory]Rac1 protein [Homo sapiens] [gi:8574038]
View
21
[SID57578339]
EC50 0.0806Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype [AID1340, Type: confirmatory]Rac1 protein [Homo sapiens] [gi:8574038]
View
22
[SID57578339]
EC50 0.0806Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype [AID1340, Type: confirmatory]Rac1 protein [Homo sapiens] [gi:8574038]
View
23
[SID57578339]
EC50 0.082SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras activated mutant, round 1 [AID588381, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
View
24
[SID57578339]
EC50 0.082SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras activated mutant, round 1 [AID588381, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
View
25
[SID57578339]
EC50 0.082SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras activated mutant, round 1 [AID588381, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
View
26
[SID57578339]
EC50 0.082SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras activated mutant, round 1 [AID588387, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
View
27
[SID57578339]
EC50 0.082SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras activated mutant, round 1 [AID588387, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
View
28
[SID57578339]
EC50 0.082SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras activated mutant, round 1 [AID588387, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
View
29
[SID57578339]
EC50 0.084SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype, round 1 [AID588393, Type: confirmatory]GTP-binding protein (rab7) [Canis lupus familiaris] [gi:164058]
View
30
[SID57578339]
EC50 0.084SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype, round 1 [AID588394, Type: confirmatory]GTP-binding protein (rab7) [Canis lupus familiaris] [gi:164058]
View
31
[SID57578339]
EC50 0.091SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant, round 1 [AID588373, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
View
32
[SID57578339]
EC50 0.091SAR compounds for Rab7 project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant, round 1 [AID588384, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
View
33
[SID24798006]
EC50 0.09198Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant [AID1333, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
View
34
[SID57578339]
EC50 0.092Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant [AID1333, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
View
35
[SID57578339]
EC50 0.0993Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype [AID1335, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
View
36
[SID57578339]
EC50 0.0993Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype [AID1335, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
View
37
[SID57578339]
EC50 0.0993Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype [AID1335, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
View
38
[SID24798006]
EC50 0.09933Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype [AID1335, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
View
39
[SID24798006]
EC50 0.09933Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype [AID1335, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
View
40
[SID24798006]
EC50 0.09933Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype [AID1335, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
View
41
[SID57578339]
EC50 0.129SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype, round 1 [AID588385, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
View
42
[SID57578339]
EC50 0.129SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype, round 1 [AID588377, Type: confirmatory]cell division control protein 42 homolog isoform 1 [Homo sapiens] [gi:4757952]
View
43
[SID57578339]
EC50 0.129SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype, round 1 [AID588377, Type: confirmatory]cell division control protein 42 homolog isoform 1 [Homo sapiens] [gi:4757952]
View
44
[SID24798006]
EC50 0.1445Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant [AID1341, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
View
45
[SID24798006]
EC50 0.1445Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant [AID1341, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
View
46
[SID24798006]
EC50 0.1445Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant [AID1341, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
View
47
[SID57578339]
EC50 0.145Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant [AID1341, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
View
48
[SID57578339]
EC50 0.145Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant [AID1341, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
View
49
[SID57578339]
EC50 0.145Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant [AID1341, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
View
50
[SID24798006]
EC50 0.1708Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype [AID1337, Type: confirmatory]Ras-related protein Rab-2 [gi:46577642]
View