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314042-01-8 (CID 1067700) - Compound BioActivity Data
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BioActivity Outcomes:
Probe(1)
 
 
Active(55)
 
 
Inactive(677)
 
 
Inconclusive(10)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
Ras like GTPa..(14)
 
 
 
 
7TM GPCR Srsx(14)
 
 
Bcl-2 like(11)
 
 
Rac1 like(10)
 
 
 
BioAssay Types:
Screening(467)
 
 
 
 
Confirmatory(236)
 
 
 
 
 
Literature(5)
 
 
Summary(1)
 
 
BioActivity Types:
Potency(145)
 
 
 
 
 
IC50(44)
 
 
 
 
EC50(41)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 662    Data Row: 744   Total Pages: 15   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85747738]
Project utilizing multiplex HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases [AID1772, Type: summary]ras protein, partial [Homo sapiens] [gi:190938]
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2
[SID85747738]
EC50_MICROM 0.02SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras wildtype, round 2 [AID588630, Type: confirmatory]ras protein, partial [Homo sapiens] [gi:190938]
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3
[SID85747738]
EC50_MICROM 0.021SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras activated mutant, round 2 [AID588628, Type: confirmatory]ras protein, partial [Homo sapiens] [gi:190938]
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4
[SID85747738]
EC50_MICROM 0.022SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype, round 2 [AID588631, Type: confirmatory]GTP-binding protein (rab7) [Canis lupus familiaris] [gi:164058]
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5
[SID24798006]
EC50_MICROM 0.05627Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype [AID1334, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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6
[SID57578339]
EC50_MICROM 0.0563Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype [AID1334, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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7
[SID57578339]
EC50_MICROM 0.078SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras wildtype, round 1 [AID588388, Type: confirmatory]ras protein, partial [Homo sapiens] [gi:190938]
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8
[SID57578339]
EC50_MICROM 0.078SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype, round 1 [AID588383, Type: confirmatory]ras protein, partial [Homo sapiens] [gi:190938]
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9
[SID24798006]
EC50_MICROM 0.08056Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype [AID1340, Type: confirmatory]Rac1 protein [Homo sapiens] [gi:8574038]
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10
[SID57578339]
EC50_MICROM 0.0806Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype [AID1340, Type: confirmatory]Rac1 protein [Homo sapiens] [gi:8574038]
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11
[SID57578339]
EC50_MICROM 0.082SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras activated mutant, round 1 [AID588387, Type: confirmatory]ras protein, partial [Homo sapiens] [gi:190938]
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12
[SID57578339]
EC50_MICROM 0.082SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras activated mutant, round 1 [AID588381, Type: confirmatory]ras protein, partial [Homo sapiens] [gi:190938]
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13
[SID57578339]
EC50_MICROM 0.084SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype, round 1 [AID588393, Type: confirmatory]GTP-binding protein (rab7) [Canis lupus familiaris] [gi:164058]
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14
[SID57578339]
EC50_MICROM 0.084SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype, round 1 [AID588394, Type: confirmatory]GTP-binding protein (rab7) [Canis lupus familiaris] [gi:164058]
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15
[SID57578339]
EC50_MICROM 0.091SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant, round 1 [AID588373, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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16
[SID57578339]
EC50_MICROM 0.091SAR compounds for Rab7 project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant, round 1 [AID588384, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
View
17
[SID24798006]
EC50_MICROM 0.09198Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant [AID1333, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
View
18
[SID57578339]
EC50_MICROM 0.092Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant [AID1333, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
View
19
[SID57578339]
EC50_MICROM 0.0993Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype [AID1335, Type: confirmatory]ras protein, partial [Homo sapiens] [gi:190938]
View
20
[SID24798006]
EC50_MICROM 0.09933Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype [AID1335, Type: confirmatory]ras protein, partial [Homo sapiens] [gi:190938]
View
21
[SID57578339]
EC50_MICROM 0.129SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype, round 1 [AID588377, Type: confirmatory]cell division control protein 42 homolog isoform 1 precursor [Homo sapiens] [gi:4757952]
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22
[SID57578339]
EC50_MICROM 0.129SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype, round 1 [AID588385, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
View
23
[SID24798006]
EC50_MICROM 0.1445Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant [AID1341, Type: confirmatory]ras protein, partial [Homo sapiens] [gi:190938]
View
24
[SID57578339]
EC50_MICROM 0.145Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant [AID1341, Type: confirmatory]ras protein, partial [Homo sapiens] [gi:190938]
View
25
[SID24798006]
EC50_MICROM 0.1708Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype [AID1337, Type: confirmatory]Ras-related protein Rab-2A [gi:46577642]
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26
[SID57578339]
EC50_MICROM 0.171Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype [AID1337, Type: confirmatory]Ras-related protein Rab-2A [gi:46577642]
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27
[SID24798006]
EC50_MICROM 0.4954Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype [AID1336, Type: confirmatory]GTP-binding protein (rab7) [Canis lupus familiaris] [gi:164058]
View
28
[SID24798006]
IC50_Mean 13.1Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay [AID588400, Type: confirmatory]phospholipase A2 precursor [Homo sapiens] [gi:4505847]
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29
[SID24798006]
Potency 22.3872qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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30
[SID24798006]
Potency 39.8107qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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31
[SID85747738]
Active GTPase Screen Compounds affects on binding of VLA-4 specific ligand [AID602148, Type: other]integrin alpha-4 precursor [Homo sapiens] [gi:67191027]
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32
[SID24798006]
HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_SinglePoint_HTS [AID485317, Type: screening]FAD-linked sulfhydryl oxidase ALR [Homo sapiens] [gi:54112432]
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33
[SID24798006]
HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype [AID761, Type: screening]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
View
34
[SID24798006]
uHTS fluorescent assay for identification of inhibitors of ATG4B [AID504462, Type: screening]cysteine protease ATG4B isoform a [Homo sapiens] [gi:47132611]
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35
[SID57578339]
Dose Response of round 1 SAR compounds for Cdc42 probe extension project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588477_1, Type: other]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
View
36
[SID57578339]
Dose Response of round 1 SAR compounds for Cdc42 probe extension project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588477_2, Type: other]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
View
37
[SID24798006]
HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype [AID760, Type: screening]Ras-related protein Rab-2A [gi:46577642]
View
38
[SID24798006]
uHTS Identification of Diaphorase Inhibitors and Chemcical Oxidizers: Counter Screen for Diaphorase-based Primary Assays [AID1217, Type: screening]Dihydrolipoamide dehydrogenase [Homo sapiens] [gi:17391426]
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39
[SID24798006]
Single concentration confirmation of inhibitors of ATG4B via a fluorescent assay [AID504757, Type: screening]cysteine protease ATG4B isoform a [Homo sapiens] [gi:47132611]
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40
[SID24798006]
HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype [AID757, Type: screening]Rac1 protein [Homo sapiens] [gi:8574038]
View
41
[SID24798006]
HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac activated mutant [AID764, Type: screening]Rac1 protein [Homo sapiens] [gi:8574038]
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42
[SID24798006]
Small Molecule Inhibitors of FGF22-Mediated Excitatory Synaptogenesis & Epilepsy Measured in Biochemical System Using RT-PCR - 7012-01_Inhibitor_SinglePoint_HTS_Activity [AID651658, Type: screening]fibroblast growth factor 22 precursor [Homo sapiens] [gi:10190672]
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43
[SID85747738]
Dose Response of round 2 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588622_3, Type: other]Rac1 protein [Homo sapiens] [gi:8574038]
View
44
[SID85747738]
Dose Response of round 2 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588622_4, Type: other]Rac1 protein [Homo sapiens] [gi:8574038]
View
45
[SID57578339]
Dose Response of round 1 SAR compounds for Cdc42 probe extension project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588477_4, Type: other]Rac1 protein [Homo sapiens] [gi:8574038]
View
46
[SID57578339]
Dose Response of round 1 SAR compounds for Cdc42 probe extension project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588477_5, Type: other]Rac1 protein [Homo sapiens] [gi:8574038]
View
47
[SID85747738]
Dose Response of round 2 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588622_5, Type: other]GTPase [Homo sapiens] [gi:407699]
View
48
[SID57578339]
Dose Response of round 1 SAR compounds for Cdc42 probe extension project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588477_8, Type: other]GTPase [Homo sapiens] [gi:407699]
View
49
[SID85747738]
Dose Response of round 2 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588622_2, Type: other]GTP-binding protein (rab7) [Canis lupus familiaris] [gi:164058]
View
50
[SID57578339]
Dose Response of round 1 SAR compounds for Cdc42 probe extension project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588477_3, Type: other]GTP-binding protein (rab7) [Canis lupus familiaris] [gi:164058]
View