Quinolinic Acid (CID 1066) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(17)
 
 
Inactive(662)
 
 
Inconclusive(58)
 
 
Unspecified(47)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
p450(13)
 
 
 
 
HELICc(9)
 
 
 
PLN02808(9)
 
 
Pyr redox dim(8)
 
 
BioAssay Types:
Confirmatory(393)
 
 
 
 
 
Screening(270)
 
 
 
 
Literature(48)
 
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(337)
 
 
 
 
 
IC50(16)
 
 
 
Ki(2)
 
 
 
EC50(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 640    Data Row: 784   Total Pages: 16   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26747101]
Potency 0.6295qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-Biphosphate Aldolase In Complex With Phosphoglycolohydrox [gi:122920737]
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2
[SID57260132]
Potency 0.7079qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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3
[SID57260132]
Potency 0.8913qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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4
[SID57260132]
Potency 1.5849qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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5
[SID11113416]
Potency 1.7783qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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6
[SID26747101]
Potency 1.9953qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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7
[SID90341105]
Potency 3.5481qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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8
[SID57260132]
Potency 6.3096qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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9
[SID50104349]
Potency 14.1254qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: Hit Validation [AID504374, Type: confirmatory]core-binding factor subunit beta isoform 2 [Homo sapiens] [gi:13124873]
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10
[SID50104349]
Potency 14.1254qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: Hit Validation [AID504374, Type: confirmatory]core-binding factor subunit beta isoform 2 [Homo sapiens] [gi:13124873]
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11
[SID11113416]
Potency 89.1251qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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12
[SID103193195]
 Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay [AID521220, Type: Literature]
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13
[SID11111698]
 qHTS Assay for Disrupters of an Hsp90 Co-Chaperone Interaction [AID595, Type: confirmatory]
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14
[SID11113416]
 qHTS Assay for Disrupters of an Hsp90 Co-Chaperone Interaction [AID595, Type: confirmatory]
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15
[SID11113416]
 qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Coupling assay counterscreen [AID2472, Type: screening]glyceraldehyde-3-phosphate dehydrogenase [Homo sapiens] [gi:7669492]
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16
[SID11113416]
 qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Coupling assay counterscreen [AID2472, Type: screening]glyceraldehyde-3-phosphate dehydrogenase [Homo sapiens] [gi:7669492]
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17
[SID26747101]
 qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Coupling assay counterscreen [AID2472, Type: screening]glyceraldehyde-3-phosphate dehydrogenase [Homo sapiens] [gi:7669492]
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18
[SID26747101]
 qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Coupling assay counterscreen [AID2472, Type: screening]glyceraldehyde-3-phosphate dehydrogenase [Homo sapiens] [gi:7669492]
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19
[SID57260132]
 ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_SinglePoint_HTS_Activity [AID623870, Type: screening]aryl hydrocarbon receptor nuclear translocator [Homo sapiens] [gi:2702319]
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20
[SID57260132]
 ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_SinglePoint_HTS_Activity [AID623870, Type: screening]aryl hydrocarbon receptor nuclear translocator [Homo sapiens] [gi:2702319]
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21
[SID57260132]
 uHTS Fluorescent Assay Using Nedd8 Protein Substrate for Identification of Inhibitors of Sentrin-Specific Protease 8 (SENP8) [AID602440, Type: screening]SENP8 gene product [Homo sapiens] [gi:262118306]
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22
[SID103193195]
IC50 100Tested in vitro for the concentration required to inhibit [3H]CPP radioligand at EAA receptor sites in rat cortical membranes [AID144992, Type: Literature]
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23
[SID103193195]
IC50 100Tested in vitro for the concentration required to inhibit [3H]AMPA radioligand at EAA receptor sites in rat cortical membranes [AID31587, Type: Literature]
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24
[SID103193195]
IC50 100Compound was evaluated for its ability to displace [3H]Glu/[3H]-AP5 from rat brain membrane [AID144611, Type: Literature]
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25
[SID103193195]
Ki 200Inhibition of Aeromonas hydrophila beta lactamase CphA by competitive inhibition assay [AID323626, Type: Literature]
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26
[SID103193195]
EC50 1500Effective concentration in vitro as electropharmacological activity in the rat cortical wedge preparation [AID175684, Type: Literature]
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27
[SID103193195]
IC50 5000Inhibition of 2-oxoglutarate-dependent human JMJD2E in prescence of excess H3K9me3 peptide and 10 uM Fe2 by FDH coupled assay [AID344917, Type: Literature]
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28
[SID103193195]
IC50 10000Inhibition of 2-oxoglutarate-dependent human JMJD2E in presence of excess 2-oxoglutarate and 10 uM Fe2 by FDH coupled assay [AID344916, Type: Literature]
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29
[SID103193195]
 Inhibition of Legionella gormani beta lactamase metallo FEZ1 expressed in Escherichia coli assessed as residual enzyme activity at 100 uM [AID323620, Type: Literature]
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30
[SID103193195]
 Inhibition of mushroom tyrosinase at 1 mM after 10 mins [AID566699, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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31
[SID103193195]
 Inhibition of recombinant anthrax lethal factor at 1 mM after 30 mins by fluorescence assay [AID566701, Type: Literature]Lethal factor [gi:50402185]
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32
[SID103193195]
 Inhibition of IL4 production in transgenic BALB/c mouse TH2 cells at 500 uM after 48 hrs [AID385990, Type: Literature]
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33
[SID103193195]
 Inhibition of IL5 production in transgenic BALB/c mouse TH2 cells at 500 uM after 48 hrs [AID385994, Type: Literature]
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34
[SID103193195]
 Inhibition of IL13 production in transgenic BALB/c mouse TH2 cells at 500 uM after 48 hrs [AID385998, Type: Literature]
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35
[SID103193195]
 Inhibition of IL10 production in transgenic BALB/c mouse TH2 cells at 500 uM after 48 hrs [AID386002, Type: Literature]
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36
[SID103193195]
 Antiasthmatic effect in ovalbumin-challenged BALB/c mouse assessed as decrease in eosinophil infiltration in bronchoalveolar lavage fluid [AID386214, Type: Literature]
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37
[SID103193195]
 Antiasthmatic effect in ovalbumin-challenged BALB/c mouse assessed as decrease in IL5 level in bronchoalveolar lavage fluid by ELISA [AID386215, Type: Literature]
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38
[SID103193195]
 Antiasthmatic effect in ovalbumin-challenged BALB/c mouse assessed as decrease in IL13 level in bronchoalveolar lavage fluid by ELISA [AID386216, Type: Literature]
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39
[SID103193195]
 Inhibition of Stenotrophomonas maltophilia metallo beta lactamase L1 assessed as residual enzyme activity at 100 uM [AID323619, Type: Literature]Metallo-beta-lactamase L1 [gi:1705478]
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40
[SID103193195]
 Neuroprotective effect evaluated for excitatory amino acid receptor antagonism with the concentration at 1 uL in the corpus striatum of 14 rats with choline acetyltransferase as the marker enzyme. [AID180056, Type: Literature]
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41
[SID103193195]
 Neuroprotective effect evaluated for excitatory amino acid receptor antagonism with the concentration at 1 uL in the corpus striatum of 14 rats with glutamic acid decarboxylase as the marker enzyme. [AID180057, Type: Literature]
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42
[SID103193195]
 Inhibition of Pseudomonas aeruginosa 101/1477 metallo beta lactamase IMP1 expressed in in Escherichia coli assessed as residual enzyme activity at 100 uM in absence of zinc [AID323613, Type: Literature]
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43
[SID103193195]
 Inhibition of Pseudomonas aeruginosa 101/1477 metallo beta lactamase IMP1 expressed in in Escherichia coli assessed as residual enzyme activity at 100 uM in presence of zinc chloride [AID323614, Type: Literature]
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44
[SID103193195]
 Inhibition of Bacillus cereus metallo beta lactamase Bc2 assessed as residual enzyme activity at 100 uM [AID323615, Type: Literature]
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45
[SID103193195]
 Inhibition of metallo beta lactamase VIM2 assessed as residual enzyme activity at 100 uM [AID323616, Type: Literature]
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46
[SID103193195]
 Inhibition of metallo beta lactamase VIM4 assessed as residual enzyme activity at 100 uM [AID323617, Type: Literature]
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47
[SID103193195]
 Inhibition of Aeromonas hydrophila metallo beta lactamase CphA assessed as residual enzyme activity at 100 uM in absence of zinc [AID323618, Type: Literature]
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48
[SID103193195]
 pKa was determined [AID143257, Type: Literature]
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49
[SID8149825]
 Screen for compounds that increase glutamate transport activity in MN-1 cell line (GluUPTAKE) [AID1612, Type: other]
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50
[SID8149825]
 Screen for compounds that inhibit protein aggregation formed by mutant SOD1 (GFPSOD1) [AID1613, Type: other]
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