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Dihydrotestosterone (CID 10635) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(123)
 
 
Inactive(725)
 
 
Inconclusive(112)
 
 
Unspecified(274)
 
 
Top Targets:
NR LBD AR(114)
 
 
 
 
 
7TM GPCR Srx(31)
 
 
 
NR LBD ER(30)
 
 
 
 
 
7TM GPCR Srsx(29)
 
 
 
NR LBD PPAR(24)
 
 
 
BioAssay Types:
Confirmatory(456)
 
 
 
 
 
Literature(285)
 
 
 
 
 
Screening(270)
 
 
 
Summary(63)
 
 
 
 
BioActivity Types:
Potency(459)
 
 
 
 
 
IC50(168)
 
 
 
 
 
EC50(25)
 
 
 
Ki(19)
 
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 944    Data Row: 1234   Total Pages: 25   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID123099348]
EC50 5e-05Agonist activity at androgen receptor expressed in mouse C2C12 cells assessed as osteoblast differentiation after 5 days [AID569780, Type: other]
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2
[SID123099348]
IC50 5e-05Activity at androgen receptor in human Saos2 cells assessed as IL6 repression [AID319592, Type: Literature]Androgen receptor [gi:113830]
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3
[SID123099348]
Kd 0.000182Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin [AID318680, Type: Literature]Sex hormone-binding globulin [gi:134907]
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4
[SID123099348]
Ki 0.0002Binding affinity to human AR [AID298549, Type: Literature]Androgen receptor [gi:113830]
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5
[SID123099348]
Ki 0.0002Binding affinity to human androgen receptor expressed in monkey COS7 cells by whole cell binding assay [AID319591, Type: Literature]Androgen receptor [gi:113830]
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6
[SID123099348]
Ki 0.0002Displacement of [3H]DHT from human androgen receptor expressed in MDA-MB-453 cells by whole cell receptor binding assay [AID272949, Type: Literature]Androgen receptor [gi:113830]
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7
[SID123099348]
Ki 0.0002Binding affinity to human androgen receptor expressed in CV1 cells [AID290231, Type: Literature]Androgen receptor [gi:113830]
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8
[SID123099348]
Ki 0.0002Binding affinity to human AR [AID293945, Type: Literature]Androgen receptor [gi:113830]
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9
[SID123099348]
Ki 0.00027Binding affinity to rat androgen receptor by competitive inhibition assay [AID348771, Type: Literature]Androgen receptor [gi:113832]
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10
[SID123099348]
Ki 0.0003Displacement of [3H]DHT from human AR expressed in MDA-MB-453 cells [AID286658, Type: Literature]Androgen receptor [gi:113830]
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11
[SID123099348]
Ki 0.0003Displacement of [3H]DHT from human AR in MDA453 cells [AID274601, Type: Literature]Androgen receptor [gi:113830]
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12
[SID123099348]
Ki 0.00069Inhibitory constant against rat prostate cytosol androgen receptor using [3H]mibolerone [AID39296, Type: Literature]Androgen receptor [gi:113832]
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13
[SID123099348]
Ki 0.0009Displacement of [3H]DHT from human Androgen receptor in human MDA-MB-453 cells [AID331664, Type: Literature]Androgen receptor [gi:113830]
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14
[SID144204607]
Potency-Replicate_1 0.0009qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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15
[SID123099348]
EC50 0.00097Agonist activity at rat androgen receptor [AID626471, Type: Literature]Androgen receptor [gi:113832]
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16
[SID123099348]
IC50 0.001Displacement of [3H]methyltrienolone from androgen receptor in human MDA-MB-453 cells [AID429503, Type: Literature]Androgen receptor [gi:113830]
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17
[SID123099348]
IC50 0.001Displacement of [3H] ]5alpha-DHT from mouse androgen receptor expressed in monkey COS7 cells after 2 hrs by scintillation counting analysis [AID733361, Type: Literature]Androgen receptor [gi:113831]
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18
[SID123099348]
EC50 0.00126Agonist activity at androgen receptor LBD T877A mutant in mouse NIH3T3 cells transiently transfected with beta-galactosidase reporter gene assessed as cellular transformation by R-SAT assay [AID445835, Type: Literature]
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19
[SID123099348]
IC50 0.00182Activity against human androgen receptor expressed in HepG2 cells assessed as luciferase reporter gene activation [AID274427, Type: Literature]Androgen receptor [gi:113830]
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20
[SID123099348]
Ki 0.002Binding affinity against Androgen receptor expressed COS cells [AID39002, Type: Literature]Androgen receptor [gi:113830]
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21
[SID123099348]
Ki 0.002Binding affinity to the human androgen receptor (hAR), using [3H]DHT as radioligand in a competitive binding assay [AID39140, Type: Literature]
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22
[SID123099348]
Ki 0.002Binding affinity towards human androgen receptor (hAR), using dihydrotestosterone as radioligand for competitive binding assay [AID39141, Type: Literature]
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23
[SID123099348]
EC50 0.002Agonist activity at androgen receptor in human MDA-MB-453 cells transfected with MMTV-LUC assessed as induction of MMTV-LTR/promoter linked LUC gene by luciferase transactivation assay [AID429504, Type: Literature]Androgen receptor [gi:113830]
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24
[SID123099348]
IC50 0.002Displacement of [3H]testosterone from androgen receptor in Sprague-Dawley rat prostate gland after 2 hrs by liquid scintillation counting [AID626482, Type: Literature]Androgen receptor [gi:113832]
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25
[SID123099348]
IC50 0.0021Displacement of [17-alpha-methyl-3H]-mibolerone from human androgen receptor expressed in HEK293 derived FreeStyle293F cells after 3 hrs [AID639076, Type: Literature]Androgen receptor [gi:113830]
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26
[SID123099348]
IC50 0.0021Inhibition of wild type Androgen receptor (unknown origin) expressed in Freestyle293F cells [AID731985, Type: Literature]Androgen receptor [gi:113830]
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27
[SID123099348]
IC50 0.0022In vitro antagonist activity against rat prostatic androgen receptor (AR) [AID39178, Type: Literature]
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28
[SID123099348]
IC50 0.00231DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) [AID625228, Type: other]Androgen receptor [gi:113832]
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29
[SID123099348]
IC50 0.0026Displacement of [17-alpha-methyl-3H]-mibolerone from human androgen receptor T877A mutant expressed in HEK293 derived FreeStyle293F cells after 3 hrs [AID639077, Type: Literature]
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30
[SID123099348]
IC50 0.0026Inhibition of Androgen receptor T877A mutant (unknown origin) expressed in Freestyle293F cells [AID731984, Type: Literature]
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31
[SID123099348]
EC50 0.0028Agonist activity at rat AR transfected in mouse C2C12 cells by luciferase reporter transactivation assay [AID274602, Type: Literature]Androgen receptor [gi:113832]
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32
[SID123099348]
Ki 0.003Binding affinity for human Androgen receptor expressed in COS-1 cells [AID39007, Type: Literature]Androgen receptor [gi:113830]
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33
[SID123099348]
IC50 0.0031Competitive binding affinity to rat androgen receptor [AID626470, Type: Literature]Androgen receptor [gi:113832]
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34
[SID144208185]
Potency-Replicate_1 0.0031qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway [AID743036, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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35
[SID123099348]
IC50 0.0031Displacement of [3H]testosterone from Sprague-Dawley rat AR by liquid scintillation counting [AID578352, Type: Literature]Androgen receptor [gi:113832]
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36
[SID144208185]
Ratio Potency (uM) 0.00329688qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway: Summary [AID743053, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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37
[SID144213957]
Potency-Replicate_1 0.0034qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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38
[SID123099348]
IC50 0.0038Inhibition of hSHBG (human sex hormone binding globulin ) [AID229012, Type: Literature]Sex hormone-binding globulin [gi:134907]
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39
[SID123099348]
EC50 0.00398Agonist activity at androgen receptor in mouse NIH3T3 cells transiently transfected with beta-galactosidase reporter gene assessed as cellular transformation by R-SAT assay [AID445833, Type: Literature]Androgen receptor [gi:113831]
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40
[SID123099348]
IC50 0.004In vitro binding affinity at human androgen receptor transfected into COS cells. [AID38985, Type: Literature]
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41
[SID123099348]
Ki 0.0047Displacement of [3H]DHT from human androgen receptor after 16 hrs by scintillation counting [AID487132, Type: Literature]Androgen receptor [gi:113830]
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42
[SID123099348]
EC50 0.005Agonist activity against Human Androgen receptor expressed in CV-1 cells [AID38803, Type: Literature]Androgen receptor [gi:113830]
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43
[SID123099348]
EC50 0.0051Agonist activity at human androgen receptor african green monkey CV1 cells by cotransfection assay [AID319588, Type: Literature]Androgen receptor [gi:113830]
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44
[SID123099348]
EC50 0.0051Agonist activity at human androgen receptor expressed in CV1 cells [AID290227, Type: Literature]Androgen receptor [gi:113830]
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45
[SID123099348]
EC50 0.0051Agonist activity at human androgen receptor by luciferase reporter gene assay [AID298545, Type: Literature]Androgen receptor [gi:113830]
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46
[SID123099348]
EC50 0.0051Agonist activity at human androgen receptor in CV1 cells measured as stimulation of luciferase reporter gene activity by cotransfection assay [AID272946, Type: Literature]Androgen receptor [gi:113830]
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47
[SID144204607]
Potency-Replicate_1 0.0054qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway [AID743036, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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48
[SID123099348]
EC50 0.0057Agonist activity at human androgen receptor expressed in CV1 cells by transcriptional activation assay [AID309193, Type: Literature]Androgen receptor [gi:113830]
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49
[SID123099348]
EC50 0.0057Agonist activity at human androgen receptor in CV1 cells by transcriptional activation assay [AID331660, Type: Literature]Androgen receptor [gi:113830]
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50
[SID123099348]
EC50 0.006Agonistic activity (EC50) against human androgen receptor expressed in CV-1 cell [AID38695, Type: Literature]Androgen receptor [gi:113830]
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