CHEMBL1159655 (CID 10578931) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(247)
 
 
Inactive(6)
 
 
Inconclusive(2)
 
 
Unspecified(385)
 
 
Top Targets:
ABC MTABC3 MD..(15)
 
 
 
7TM GPCR Srx(12)
 
 
 
p450(12)
 
 
 
7TM GPCR Srsx(10)
 
 
 
ALBUMIN(6)
 
 
 
BioAssay Types:
Literature(495)
 
 
 
 
 
BioActivity Types:
IC50(195)
 
 
 
EC50(119)
 
 
 
Ki(29)
 
 
 
Kd(5)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 640    Data Row: 640   Total Pages: 13   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103759741]
Ki 1e-05Inhibition of HIV protease [AID160300, Type: Literature]Pol polyprotein [gi:75593047]
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2
[SID103759741]
Ki 7e-05Inhibition of wild-type HIV1 BH10 protease expressed in Escherichia coli by spectrophotometric assay [AID343014, Type: Literature]
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3
[SID103759741]
Ki 0.00014Dissociation constant obtained by inhibition of Wild-type protease [AID219260, Type: Literature]
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4
[SID103759741]
Ki 0.00017Inhibition of HIV-1 Protease activity [AID161524, Type: Literature]
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5
[SID103759741]
Ki 0.00023Inhibitory concentration against HIV-1 protease [AID160481, Type: Literature]Pol polyprotein [gi:75593047]
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6
[SID103759741]
Ki 0.00028Inhibition of HIV1 protease [AID282343, Type: Literature]
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7
[SID103759741]
Ki 0.000306Inhibition of HIV1 protease [AID374591, Type: Literature]
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8
[SID103759741]
Ki 0.00054Inhibition constant against HIV-1 Protease [AID160455, Type: Literature]Pol polyprotein [gi:75593047]
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9
[SID103759741]
Ki 0.00054Inhibition constant for human immunodeficiency virus type 1 protease [AID238682, Type: Literature]
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10
[SID103759741]
Ki 0.000931Inhibition of HIV1 protease [AID321660, Type: Literature]
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11
[SID103759741]
Kd 0.00164Equilibrium constant for the interaction between inhibitor and HIV-1 Protease [AID162706, Type: Literature]Pol polyprotein [gi:75593047]
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12
[SID103759741]
Kd 0.00164Binding affinity for human immunodeficiency virus type 1 protease [AID238043, Type: Literature]
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13
[SID103759741]
EC50 0.00167Antiviral activity against wild type HIV1 subtype C infected in human cord blood mononuclear cells assessed as inhibition of viral replication after 48 hrs by luciferase reporter gene assay [AID546994, Type: Literature]
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14
[SID103759741]
IC50 0.0019Inhibition of recombinant wild type HIV1 protease assessed as hydrolysis of fluorogenic substrate [AID458605, Type: Literature]
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15
[SID103759741]
IC50 0.002Antiviral activity against Human immunodeficiency virus type 1 (BRU ISOLATE) after 13 months [AID521548, Type: Literature]
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16
[SID103759741]
IC50 0.002Antiviral activity against HIV1 LAI infected in human CEM-SS cells assessed as reverse transcriptase activity after 5 days by MTT assay [AID371125, Type: Literature]
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17
[SID103759741]
Ki 0.0021Inhibition of HIV1 recombinant protease L10I/I15V/E35D/N37S/R41K/I62V/L63P/A71V/G73S/L90M mutant expressed in Escherichia coli by spectrophotometric assay [AID343019, Type: Literature]
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18
[SID103759741]
Kd 0.00299Binding affinity to Human immunodeficiency virus 1 protease by SPR biosensor interaction analysis at pH 5.1 [AID673197, Type: Literature]
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19
[SID103759741]
Ki 0.0032Inhibition of HIV1 recombinant protease A71V/V82T/I84V mutant expressed in Escherichia coli by spectrophotometric assay [AID343017, Type: Literature]
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20
[SID103759741]
Kd 0.0034Binding affinity to Human immunodeficiency virus 1 protease by SPR biosensor interaction analysis at pH 7.4 [AID673196, Type: Literature]
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21
[SID103759741]
Ki 0.0038Inhibition of HIV1 recombinant protease M46I/A71V/V82T/I84V mutant expressed in Escherichia coli by spectrophotometric assay [AID343016, Type: Literature]
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22
[SID103759741]
EC50 0.0054Antiviral activity against wild type HIV1 [AID321685, Type: Literature]
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23
[SID103759741]
EC50 0.0057Antiviral activity against wild type HIV1 subtype CRF02_AG infected in human cord blood mononuclear cells assessed as inhibition of viral replication after 48 hrs by luciferase reporter gene assay [AID547002, Type: Literature]
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24
[SID103759741]
EC50 0.0058Antiviral activity against wild type HIV1 NL4-3 in HEK293 cells after 48 hrs by replication-defective luciferase reporter gene-based phenotypic assay [AID374600, Type: Literature]
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25
[SID103759741]
IC50 0.007Antiviral activity against HIV1 BA-L isolate in human PHA-PBMC cells [AID269306, Type: Literature]
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26
[SID103759741]
IC50 0.009Inhibition of wild type HIV-1 protease assessed as hydrolysis of fluorogenic substrate Abz-Thr-Ile-Nle-Phe(NO2)-Gln-Arg after 10 mins by fluorescence assay [AID656209, Type: Literature]
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27
[SID103759741]
EC50 0.0098Antiviral activity against wild type HIV1 subtype B infected in human cord blood mononuclear cells assessed as inhibition of viral replication after 48 hrs by luciferase reporter gene assay [AID546992, Type: Literature]
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28
[SID103759741]
IC50 0.01Antiviral activity against HIV1 isolate 5512 with M36I/M and V82T mutation in CBMCs [AID279348, Type: Literature]
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29
[SID103759741]
IC50 0.01Antiviral activity against HIV1 LAI isolate in human MT2 cells [AID269304, Type: Literature]
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30
[SID103759741]
Ki 0.01Inhibition of HIV1 recombinant protease V32I/I47A mutant expressed in Escherichia coli by spectrophotometric assay [AID343018, Type: Literature]
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31
[SID103759741]
EC50 0.011Antiviral activity against HIV1 NL4-3 harboring L10F/L33F/M46I/I47V/Q58E/V82I/I84V/I85V amino acid substitution in protease encoding region infected in human MT4 cells assessed as inhibition of p24 Gag protein production selected at 5 uM of GRL-02031 by ELISA [AID557292, Type: Literature]
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32
[SID103759741]
IC50 0.012Antiviral activity against R5 tropic HIV1 Ba-L infected in human PBMC assessed as inhibition of HIN p24 antigen expression [AID568182, Type: Literature]
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33
[SID103759741]
IC50 0.012Antiviral activity against HIV1 Ba-L(R5) infected in human PBMC by p24 antigen capture assay [AID454923, Type: Literature]
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34
[SID103759741]
IC50 0.012Antiviral activity against R5 tropic HIV1 Ba-L infected PBMC assessed as inhibition of viral p24 antigen expression [AID612003, Type: Literature]
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35
[SID103759741]
IC50 0.012Antiviral activity against HIV1 BAL by p24 assay [AID492209, Type: Literature]
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36
[SID103759741]
EC50 0.013Antiviral activity against HIV1 harboring capsid I201V mutant protein infected in human HeLa cells assessed as decrease in viral infection after 72 hrs by beta-galactosidase reporter gene assay [AID562702, Type: Literature]
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37
[SID103759741]
IC50 0.014Antiviral activity against HIV1 LAI isolate in human PHA-PBMC cells [AID269305, Type: Literature]
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38
[SID103759741]
IC50 0.014Antiviral activity against wild type HIV1 in CBMCs [AID279345, Type: Literature]
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39
[SID103759741]
EC50 0.015Antiviral activity against wild type HIV1 ERS104prc X4 in phytohemagglutinin-activated PBMCs assessed as inhibition of p24 Gag protein expression by MTT assay [AID322112, Type: Literature]
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40
[SID103759741]
EC50 0.016Antiviral activity against HIV1 3B in MT4 cells by MTT assay [AID290994, Type: Literature]
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41
[SID103759741]
EC50 0.016Antiviral activity against HIV1 3B in human MT4 cells assessed as inhibition of viral-induced cytopathic effect by MTT method [AID408207, Type: Literature]
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42
[SID103759741]
EC50 0.016Antiviral activity against wild type HIV1 infected in human HeLa cells assessed as decrease in viral infection after 72 hrs by beta-galactosidase reporter gene assay [AID562701, Type: Literature]
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43
[SID103759741]
EC50 0.016Antiviral activity against HIV1 ERS104pre infected in human PHA-PBC assessed as inhibition of p24 Gag protein production by ELISA [AID553574, Type: Literature]
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44
[SID103759741]
Ki 0.016Dissociation constant obtained by inhibition of mutant HIV-protease (A-44) [AID225562, Type: Literature]
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45
[SID103759741]
EC50 0.018Antiviral activity against HIV1 NL4-3 infected in human MT4 cells assessed as inhibition of p24 gag protein production by ELISA [AID557284, Type: Literature]
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46
[SID103759741]
EC50 0.018Antiviral activity against HIV1 NL4-3 infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect after 5 days by MTT assay [AID369838, Type: Literature]
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47
[SID103759741]
EC50 0.018Antiviral activity against HIV1 BaL R5 subtype B in phytohemagglutinin-activated PBMCs assessed as inhibition of p24 Gag protein expression by MTT assay [AID322121, Type: Literature]
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48
[SID103759741]
Ki 0.018Inhibition of HIV1 recombinant protease D30N/N88D mutant expressed in Escherichia coli by spectrophotometric assay [AID343015, Type: Literature]
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49
[SID103759741]
EC50 0.019Antiviral activity against HIV1 3B [AID321661, Type: Literature]
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50
[SID103759741]
IC50 0.02Antiviral activity against HIV2 EHO isolate in human MT2 cells [AID269307, Type: Literature]
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