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CHEMBL1159655 (CID 10578931) - Compound BioActivity Data
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BioActivity Outcomes:
Active(249)
 
 
Inactive(6)
 
 
Inconclusive(2)
 
 
Unspecified(413)
 
 
Top Targets:
7TM GPCR Srx(17)
 
 
 
7TM GPCR Srsx(15)
 
 
 
ABC MTABC3 MD..(15)
 
 
 
p450(14)
 
 
 
ALBUMIN(6)
 
 
 
BioAssay Types:
Literature(536)
 
 
 
 
 
Confirmatory(116)
 
 
 
BioActivity Types:
IC50(195)
 
 
 
EC50(119)
 
 
 
Ki(31)
 
 
 
Kd(5)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 670    Data Row: 670   Total Pages: 34   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103759741]
Ki 1e-05Inhibition of HIV protease [AID160300, Type: Literature]Pol polyprotein [gi:75593047]
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2
[SID103759741]
Ki 7e-05Inhibition of wild-type HIV1 BH10 protease expressed in Escherichia coli by spectrophotometric assay [AID343014, Type: Literature]
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3
[SID103759741]
Ki 0.00014Dissociation constant obtained by inhibition of Wild-type protease [AID219260, Type: Literature]
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4
[SID103759741]
Ki 0.00017Inhibition of HIV-1 Protease activity [AID161524, Type: Literature]
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5
[SID103759741]
Ki 0.00023Inhibitory concentration against HIV-1 protease [AID160481, Type: Literature]Pol polyprotein [gi:75593047]
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6
[SID103759741]
Ki 0.00028Inhibition of HIV1 protease [AID282343, Type: Literature]
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7
[SID103759741]
Ki 0.000306Inhibition of HIV1 protease [AID374591, Type: Literature]
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8
[SID103759741]
Ki 0.00054Inhibition constant for human immunodeficiency virus type 1 protease [AID238682, Type: Literature]
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9
[SID103759741]
Ki 0.00054Inhibition constant against HIV-1 Protease [AID160455, Type: Literature]Pol polyprotein [gi:75593047]
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10
[SID103759741]
Ki 0.000931Inhibition of HIV1 protease [AID321660, Type: Literature]
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11
[SID103759741]
Kd 0.00164Binding affinity for human immunodeficiency virus type 1 protease [AID238043, Type: Literature]
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12
[SID103759741]
Kd 0.00164Equilibrium constant for the interaction between inhibitor and HIV-1 Protease [AID162706, Type: Literature]Pol polyprotein [gi:75593047]
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13
[SID103759741]
EC50 0.00167Antiviral activity against wild type HIV1 subtype C infected in human cord blood mononuclear cells assessed as inhibition of viral replication after 48 hrs by luciferase reporter gene assay [AID546994, Type: Literature]
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14
[SID103759741]
IC50 0.0019Inhibition of recombinant wild type HIV1 protease assessed as hydrolysis of fluorogenic substrate [AID458605, Type: Literature]
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15
[SID103759741]
Ki 0.002Binding affinity against HIV-protease inhibitor. [AID161874, Type: Literature]
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16
[SID103759741]
IC50 0.002Antiviral activity against Human immunodeficiency virus type 1 (BRU ISOLATE) after 13 months [AID521548, Type: Literature]
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17
[SID103759741]
IC50 0.002Antiviral activity against HIV1 LAI infected in human CEM-SS cells assessed as reverse transcriptase activity after 5 days by MTT assay [AID371125, Type: Literature]
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18
[SID103759741]
Ki 0.0021Inhibition of HIV1 recombinant protease L10I/I15V/E35D/N37S/R41K/I62V/L63P/A71V/G73S/L90M mutant expressed in Escherichia coli by spectrophotometric assay [AID343019, Type: Literature]
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19
[SID103759741]
Kd 0.00299Binding affinity to Human immunodeficiency virus 1 protease by SPR biosensor interaction analysis at pH 5.1 [AID673197, Type: Literature]
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20
[SID103759741]
Ki 0.0032Inhibition of HIV1 recombinant protease A71V/V82T/I84V mutant expressed in Escherichia coli by spectrophotometric assay [AID343017, Type: Literature]
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