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BioActivity Data for Compound CHEMBL1159655 (CID 10578931)

BioActivity Outcomes:
Active(33)
 
 
Unspecified(146)
 
 
Top Targets:
7tm 4(30)
 
 
 
ABC MTABC3 MD..(15)
 
 
 
p450(14)
 
 
 
ALBUMIN(6)
 
 
 
KAZAL SLC21(5)
 
 
BioAssay Types:
Confirmatory(115)
 
 
 
Literature(46)
 
 
 
BioActivity Types:
IC50(127)
 
 
 
Ki(7)
 
 
 
EC50(1)
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 179    Data Row: 179   Total Pages: 9   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103759741]
Ki 1e-05Inhibition of HIV protease [AID160300, Type: Literature]Pol polyprotein [gi:75593047]
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2
[SID103759741]
Ki 0.00017Inhibition of HIV-1 Protease activity [AID161524, Type: Literature]
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3
[SID103759741]
Ki 0.00023Inhibitory concentration against HIV-1 protease [AID160481, Type: Literature]Pol polyprotein [gi:75593047]
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4
[SID103759741]
Ki 0.00054Inhibition constant against HIV-1 Protease [AID160455, Type: Literature]Pol polyprotein [gi:75593047]
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5
[SID103759741]
Kd 0.00164Equilibrium constant for the interaction between inhibitor and HIV-1 Protease [AID162706, Type: Literature]Pol polyprotein [gi:75593047]
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6
[SID103759741]
EC50 0.05Antiretroviral activity against Human immunodeficiency virus 2 ROD infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay [AID573977, Type: Literature]
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7
[SID103759741]
IC50 0.05Antiviral activity against Human immunodeficiency virus type 2 (ISOLATE ROD) after 13 months [AID521547, Type: Literature]
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8
[SID103759741]
IC50 0.32Inhibitory concentration against wild type Human immuno deficiency virus (HXB2) was determined in an MT-4 cell line [AID248546, Type: Literature]
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9
[SID103759741]
IC50 0.45Inhibitory concentration against wild type Human immuno deficiency virus (EP13) was determined in an MT-4 cell line [AID248545, Type: Literature]
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10
[SID103759741]
Ki 1Time dependent inhibition of CYP3A4-mediated testosterone-6-beta hydroxylation in human liver microsome [AID705597, Type: Literature]Cytochrome P450 3A4 [gi:116241312]
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11
[SID103759741]
IC50 1.881DRUGMATRIX: Sodium Channel, Site 2 radioligand binding (ligand: [3H] Batrachotoxin) [AID625225, Type: confirmatory]
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12
[SID103759741]
IC50 2DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) [AID625251, Type: confirmatory]Cytochrome P450 3A4 [gi:116241312]
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13
[SID103759741]
IC50 7.971DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr)) [AID625185, Type: confirmatory]Tyrosine-protein kinase Fyn [gi:125370]
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14
[SID103759741]
IC50 8.852DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625207, Type: confirmatory]Sodium-dependent noradrenaline transporter [gi:128616]
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15
[SID103759741]
IC50 9.84DRUGMATRIX: Calcium Channel Type L, Dihydropyridine radioligand binding (ligand: [3H] Nitrendipine) [AID625216, Type: confirmatory]
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16
[SID103759741]
IC50 12.935DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) [AID625252, Type: confirmatory]D(1A) dopamine receptor [gi:118228]
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17
[SID103759741]
IC50 13.797DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) [AID625146, Type: confirmatory]Arachidonate 15-lipoxygenase [gi:126397]
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18
[SID103759741]
IC50 14.432DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) [AID625163, Type: confirmatory]Mu-type opioid receptor [gi:2851402]
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19
[SID103759741]
IC50 14.59DRUGMATRIX: Calcium Channel Type L, Benzothiazepine radioligand binding (ligand: [3H] Diltiazem) [AID625215, Type: confirmatory]
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20
[SID103759741]
IC50 14.796DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) [AID625196, Type: confirmatory]Adenosine receptor A3 [gi:1351831]
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