Bookmark and Share

BioActivity Data for Compound Pyridoxine (CID 1054)

BioActivity Outcomes:
Active(6)
 
 
Inactive(309)
 
 
Inconclusive(16)
 
 
Unspecified(36)
 
 
Top Targets:
NR LBD PPAR(16)
 
 
NR LBD AR(14)
 
 
 
NR LBD ER(14)
 
 
p450(13)
 
 
NR LBD GR(10)
 
 
 
BioAssay Types:
Confirmatory(248)
 
 
 
 
Summary(52)
 
 
 
Literature(38)
 
 
 
 
Screening(11)
 
 
BioAssay Categories:
Biochemical(2)
 
 
 
Toxicity(34)
 
 
 
ADME(7)
 
 
Cell-based(8)
 
 
BioActivity Types:
Potency(259)
 
 
 
 
AC50(3)
 
 
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 260    Data Row: 367   Total Pages: 19   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103450438]
Km 9.9Activity at human PKH kinase expressed in Escherichia coli by affinity chromatography [AID464423, Type: Literature]Pyridoxal kinase [gi:2811007]
View
2
[SID144207193]
Potency 28.1838qHTS for Inhibitors of binding or entry into cells for Marburg Virus [AID720532, Type: confirmatory]gene 4 small orf - Marburg virus [Marburg marburgvirus] [gi:420597]
View
3
[SID48416500]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
View
4
[SID103450438]
Increase in seed vigor in Cenchrus americanus cultivar 7042S at 20 mM incubated for 6 hr followed by sowing measured at 7-day old seedling stage relative to control [AID1087753, Type: Literature]
View
5
[SID11112145]
qHTS Assay for Spectroscopic Profiling in A350 Spectral Region [AID590, Type: other]
View
6
[SID11112145]
qHTS Assay for Spectroscopic Profiling in 4-MU Spectral Region [AID589, Type: other]
View
7
[SID11112145]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
View
8
[SID103450438]
Moderate liver toxicity, defined via clinical-chemistry results: ALT or AST serum activity 6 times the normal upper limit (N) or alkaline phosphatase serum activity of 1.7 N. Value is number of references indexed. [column 'BIOL' in source] [AID1079931, Type: Literature]
View
9
[SID103450438]
Highest frequency of moderate liver toxicity observed during clinical trials, expressed as a percentage. [column '% BIOL' in source] [AID1079932, Type: Literature]
View
10
[SID103450438]
Acute liver toxicity defined via clinical observations and clear clinical-chemistry results: serum ALT or AST activity > 6 N or serum alkaline phosphatases activity > 1.7 N. This category includes cytolytic, choleostatic and mixed liver toxicity. Value is number of references indexed. [column 'AIGUE' in source] [AID1079933, Type: Literature]
View
11
[SID103450438]
Highest frequency of acute liver toxicity observed during clinical trials, expressed as a percentage. [column '% AIGUE' in source] [AID1079934, Type: Literature]
View
12
[SID103450438]
Cytolytic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is > 5 (see ACUTE). Value is number of references indexed. [column 'CYTOL' in source] [AID1079935, Type: Literature]
View
13
[SID103450438]
Choleostatic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is < 2 (see ACUTE). Value is number of references indexed. [column 'CHOLE' in source] [AID1079936, Type: Literature]
View
14
[SID103450438]
Severe hepatitis, defined as possibly life-threatening liver failure or through clinical observations. Value is number of references indexed. [column 'MASS' in source] [AID1079937, Type: Literature]
View
15
[SID103450438]
Chronic liver disease either proven histopathologically, or through a chonic elevation of serum amino-transferase activity after 6 months. Value is number of references indexed. [column 'CHRON' in source] [AID1079938, Type: Literature]
View
16
[SID103450438]
Cirrhosis, proven histopathologically. Value is number of references indexed. [column 'CIRRH' in source] [AID1079939, Type: Literature]
View
17
[SID103450438]
Granulomatous liver disease, proven histopathologically. Value is number of references indexed. [column 'GRAN' in source] [AID1079940, Type: Literature]
View
18
[SID103450438]
Liver damage due to vascular disease: peliosis hepatitis, hepatic veno-occlusive disease, Budd-Chiari syndrome. Value is number of references indexed. [column 'VASC' in source] [AID1079941, Type: Literature]
View
19
[SID103450438]
Steatosis, proven histopathologically. Value is number of references indexed. [column 'STEAT' in source] [AID1079942, Type: Literature]
View
20
[SID103450438]
Malignant tumor, proven histopathologically. Value is number of references indexed. [column 'T.MAL' in source] [AID1079943, Type: Literature]
View