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U 69593 (CID 105104) - Compound BioActivity Data
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BioActivity Outcomes:
Active(52)
 
 
Inactive(133)
 
 
Inconclusive(42)
 
 
Unspecified(23)
 
 
Top Targets:
NR LBD PPAR(8)
 
 
7TM GPCR Srx(8)
 
 
 
NR LBD ER(7)
 
 
7TM GPCR Srsx(7)
 
 
 
 
NR LBD AR(7)
 
 
BioAssay Types:
Confirmatory(118)
 
 
 
 
Literature(104)
 
 
 
 
 
Summary(24)
 
 
 
Screening(2)
 
 
BioActivity Types:
Potency(131)
 
 
 
 
Ki(5)
 
 
EC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 186    Data Row: 250   Total Pages: 13   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103177815]
Ki 0.002Binding affinity towards Mutant D216N, D217N, E218Q Opioid receptor kappa 1 EL-2 expressed in HEK cells [AID141256, Type: Literature]
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2
[SID103177815]
EC50 0.0022Effective concentration required for in vitro agonist potency in guinea-pig ileum myenteric plexus preparation (GPI) [AID73741, Type: confirmatory]
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3
[SID103177815]
Ki 0.0024Binding affinity towards Mutant E203Q, D204N, D206N, Opioid receptor kappa 1 EL-2 expressed in HEK cells [AID141261, Type: Literature]
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4
[SID103177815]
Ki 0.003Binding affinity towards mutant E203Q,D204N,D206N,E209Q Opioid receptor kappa 1 EL-2 expressed in HEK cells [AID141263, Type: Literature]
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5
[SID103177815]
Ki 0.0073Binding affinity for the Opioid receptor kappa 1 [AID149131, Type: Literature]Kappa-type opioid receptor [gi:730228]
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6
[SID103177815]
ED50 0.024Effective dose for agonistic activity towards human kappa opioid receptor from membranes of HEK293 cells was determined by radiolabeled [35S]GTP-gamma-S, assay [AID147846, Type: Literature]
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7
[SID103177815]
EC50 0.028Effective concentration required for in vitro evaluation of agonist activity on mouse vas deferens preparation [AID127786, Type: confirmatory]
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8
[SID103177815]
Ki 0.052Binding affinity for the Opioid receptor mu 1 [AID147910, Type: Literature]Mu-type opioid receptor [gi:3024265]
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9
[SID103177815]
ED50 0.684Ability to stimulate binding to mu-opioid receptor using GTP-gamma -S-binding assay in guinea pig caudate membranes under unblocked condition [AID152215, Type: Literature]Mu-type opioid receptor [gi:3024265]
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10
[SID103177815]
ED50 1.98Ability to stimulate binding to delta-opioid receptor using GTP-gamma -S-binding assay in guinea pig caudate membranes, blocked with 20 nM naltrindole (NTI) [AID149616, Type: Literature]
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11
[SID103177815]
ED50 2.142Ability to stimulate binding to mu-opioid receptor using GTP-gamma -S-binding assay in guinea pig caudate membranes, blocked with 6000 nM CTAP [AID152216, Type: Literature]Mu-type opioid receptor [gi:3024265]
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12
[SID26756545]
Potency 13.4591Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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13
[SID26756545]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_60, Type: Literature]
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14
[SID26756545]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_61, Type: Literature]
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15
[SID26756545]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_46, Type: Literature]
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16
[SID26756545]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_50, Type: Literature]
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17
[SID103177815]
Ability to stimulate binding to mu-opioid receptor using GTP-gamma -S-binding assay in guinea pig caudate membranes under unblocked condition [AID152217, Type: Literature]Mu-type opioid receptor [gi:3024265]
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18
[SID103177815]
Ability to stimulate binding to mu-opioid receptor using GTP-gamma -S-binding assay in guinea pig caudate membranes, blocked with 6000 nM CTAP [AID152218, Type: Literature]Mu-type opioid receptor [gi:3024265]
View
19
[SID103177815]
Ability to stimulate binding to delta-opioid receptor using GTP-gamma -S-binding assay in guinea pig caudate membranes, blocked with 20 nM naltrindole (NTI) [AID149617, Type: Literature]
View
20
[SID103177815]
In vitro evaluation of antagonist activity induced by naloxone on mouse vas deferens preparation [AID134207, Type: other]
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