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U 69593 (CID 105104) - Compound BioActivity Data
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BioActivity Outcomes:
Active(53)
 
 
Inactive(127)
 
 
Inconclusive(46)
 
 
Unspecified(23)
 
 
Top Targets:
NR LBD PPAR(8)
 
 
 
7TM GPCR Srx(8)
 
 
 
NR LBD ER(7)
 
 
7TM GPCR Srsx(7)
 
 
 
 
NR LBD AR(7)
 
 
 
BioAssay Types:
Confirmatory(115)
 
 
 
 
Literature(104)
 
 
 
 
 
Summary(24)
 
 
 
Screening(2)
 
 
BioActivity Types:
Potency(130)
 
 
 
 
Ki(5)
 
 
EC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 185    Data Row: 249   Total Pages: 5   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103177815]
Ki 0.002Binding affinity towards Mutant D216N, D217N, E218Q Opioid receptor kappa 1 EL-2 expressed in HEK cells [AID141256, Type: Literature]
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2
[SID103177815]
EC50 0.0022Effective concentration required for in vitro agonist potency in guinea-pig ileum myenteric plexus preparation (GPI) [AID73741, Type: other]
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3
[SID103177815]
Ki 0.0024Binding affinity towards Mutant E203Q, D204N, D206N, Opioid receptor kappa 1 EL-2 expressed in HEK cells [AID141261, Type: Literature]
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4
[SID103177815]
Ki 0.003Binding affinity towards mutant E203Q,D204N,D206N,E209Q Opioid receptor kappa 1 EL-2 expressed in HEK cells [AID141263, Type: Literature]
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5
[SID103177815]
Ki 0.0073Binding affinity for the Opioid receptor kappa 1 [AID149131, Type: Literature]Kappa-type opioid receptor [gi:730228]
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6
[SID103177815]
ED50 0.024Effective dose for agonistic activity towards human kappa opioid receptor from membranes of HEK293 cells was determined by radiolabeled [35S]GTP-gamma-S, assay [AID147846, Type: Literature]
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7
[SID103177815]
EC50 0.028Effective concentration required for in vitro evaluation of agonist activity on mouse vas deferens preparation [AID127786, Type: other]
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8
[SID103177815]
Ki 0.052Binding affinity for the Opioid receptor mu 1 [AID147910, Type: Literature]Mu-type opioid receptor [gi:3024265]
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9
[SID103177815]
ED50 0.684Ability to stimulate binding to mu-opioid receptor using GTP-gamma -S-binding assay in guinea pig caudate membranes under unblocked condition [AID152215, Type: Literature]Mu-type opioid receptor [gi:3024265]
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10
[SID103177815]
ED50 1.98Ability to stimulate binding to delta-opioid receptor using GTP-gamma -S-binding assay in guinea pig caudate membranes, blocked with 20 nM naltrindole (NTI) [AID149616, Type: Literature]
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11
[SID103177815]
ED50 2.142Ability to stimulate binding to mu-opioid receptor using GTP-gamma -S-binding assay in guinea pig caudate membranes, blocked with 6000 nM CTAP [AID152216, Type: Literature]Mu-type opioid receptor [gi:3024265]
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12
[SID26756545]
Potency 13.4591Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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13
[SID144205579]
Potency-Replicate_1 26.6032qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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14
[SID103177815]
[35S]GTP-gamma-S, induced maximal stimulation ( E max )against Kappa opioid receptor in guinea pig caudate membranes blocked with 6 nM nor-BNI [AID95205, Type: Literature]Kappa-type opioid receptor [gi:730228]
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15
[SID103177815]
[35S]GTP-gamma-S, induced maximal stimulation ( E max ) against Mu opioid receptor in guinea pig caudate membranes blocked with 6000 nM CTAP [AID138842, Type: Literature]Mu-type opioid receptor [gi:3024265]
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16
[SID103177815]
[35S]GTP-gamma-S, induced maximal stimulation ( E max )against Mu opioid receptor in guinea pig caudate membranes in unblocked condition [AID138846, Type: Literature]Mu-type opioid receptor [gi:3024265]
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17
[SID26756545]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_60, Type: Literature]
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18
[SID26756545]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_61, Type: Literature]
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19
[SID26756545]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_46, Type: Literature]
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20
[SID26756545]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_50, Type: Literature]
View
21
[SID103177815]
Ability to stimulate binding to mu-opioid receptor using GTP-gamma -S-binding assay in guinea pig caudate membranes under unblocked condition [AID152217, Type: Literature]Mu-type opioid receptor [gi:3024265]
View
22
[SID103177815]
Ability to stimulate binding to mu-opioid receptor using GTP-gamma -S-binding assay in guinea pig caudate membranes, blocked with 6000 nM CTAP [AID152218, Type: Literature]Mu-type opioid receptor [gi:3024265]
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23
[SID103177815]
Ability to stimulate binding to delta-opioid receptor using GTP-gamma -S-binding assay in guinea pig caudate membranes, blocked with 20 nM naltrindole (NTI) [AID149617, Type: Literature]
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24
[SID26756545]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_2, Type: Literature]
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25
[SID26756545]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_3, Type: Literature]
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26
[SID26756545]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_4, Type: Literature]
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27
[SID26756545]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_7, Type: Literature]
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28
[SID26756545]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_10, Type: Literature]
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29
[SID26756545]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_11, Type: Literature]
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30
[SID26756545]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_15, Type: Literature]
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31
[SID103177815]
In vitro evaluation of antagonist activity induced by naloxone on mouse vas deferens preparation [AID134207, Type: other]
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32
[SID103177815]
In vitro evaluation of antagonistic activity induced by naloxone in guinea-pig ileum myenteric plexus preparation (GPI) [AID77771, Type: other]
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33
[SID103177815]
[35S]GTP-gamma-S, induced maximal stimulation ( E max ) Delta opioid receptor in guinea pig caudate membranes blocked with 20 nM NTI [AID56285, Type: Literature]
View
34
[SID26756545]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_23, Type: Literature]
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35
[SID26756545]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_24, Type: Literature]
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36
[SID26756545]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_25, Type: Literature]
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37
[SID26756545]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_26, Type: Literature]
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38
[SID26756545]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_19, Type: Literature]
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39
[SID26756545]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_20, Type: Literature]
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40
[SID26756545]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_32, Type: Literature]
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41
[SID26756545]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_33, Type: Literature]
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42
[SID26756545]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_34, Type: Literature]
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43
[SID26756545]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_35, Type: Literature]
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44
[SID26756545]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_36, Type: Literature]
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45
[SID26756545]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_13, Type: Literature]
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46
[SID26756545]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_39, Type: Literature]
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47
[SID26756545]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_42, Type: Literature]
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48
[SID26756545]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_52, Type: Literature]
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49
[SID26756545]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_53, Type: Literature]
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50
[SID26756545]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_54, Type: Literature]
View