pyrazole (CID 1048) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(2)
 
 
Inactive(62)
 
 
Inconclusive(4)
 
 
Unspecified(4)
 
 
Top Targets:
p450(2)
 
 
BioAssay Types:
Confirmatory(53)
 
 
Literature(4)
 
 
 
BioActivity Types:
IC50(2)
 
 
 
Ki(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 72    Data Row: 72   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103178818]
Ki 1.86209Inhibitory activity against horse liver alcohol dehydrogenase (ADH) [AID33855, Type: Literature]
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2
[SID103178818]
IC50 9.8Inhibition of Sprague-Dawley rat cytosolic alcohol dehydrogenase [AID334144, Type: other]
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3
[SID103178818]
IC50 200Inhibition of KDM4C catalytic core-mediated demethylation of ARK(Me)3STGGK after 30 mins by FDH-coupled assay [AID678707, Type: Literature]
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4
[SID103178818]
 Clinically relevant inducers of human liver microsomal P450 enzymes, isoform CYP2A6 [AID589050, Type: other]Cytochrome P450 2A6 [gi:308153612]
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5
[SID103178818]
 Inhibition of Thromboxane synthetase at 100 uM [AID213129, Type: Literature]Thromboxane-A synthase [gi:254763392]
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6
[SID103178818]
 Partition coefficient (logP) [AID23467, Type: Literature]
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7
[SID99139]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model L1210 Leukemia (intraperitoneal) in B6D2F1 (BDF1) mice [AID248, Type: other]
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8
[SID99139]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model Lewis Lung Carcinoma (subcutaneous) in B6D2F1 (BDF1) mice [AID270, Type: other]
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9
[SID99139]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model Lewis Lung Carcinoma (intravenous) in B6D2F1 (BDF1) mice [AID274, Type: other]
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10
[SID99139]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model Human Amelanotic Melanoma (LOX) (intraperitoneal) in NU/NU BALB/C (nude) mice [AID280, Type: other]
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11
[SID99139]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model Human Mammary Carcinoma MX-1 Xenograft (intrarenal inoculation) in NU/NU Swiss (nude) mice [AID296, Type: other]
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12
[SID99139]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model P388 Leukemia (intraperitoneal) in B6D2F1 (BDF1) mice [AID328, Type: other]
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13
[SID99139]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model P388 Leukemia (intraperitoneal) in CD2F1 (CDF1) mice [AID330, Type: other]
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14
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the NCI-H460 Non-Small Cell Lung cell line [AID7, Type: confirmatory]
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15
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the HOP-62 Non-Small Cell Lung cell line [AID9, Type: confirmatory]
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16
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line [AID13, Type: confirmatory]
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17
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line [AID19, Type: confirmatory]
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18
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the EKVX Non-Small Cell Lung cell line [AID21, Type: confirmatory]
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19
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the LOX IMVI Melanoma cell line [AID23, Type: confirmatory]
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20
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line [AID29, Type: confirmatory]
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21
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the UACC-62 Melanoma cell line [AID31, Type: confirmatory]
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22
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-2 Melanoma cell line [AID35, Type: confirmatory]
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23
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line [AID37, Type: confirmatory]
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24
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-28 Melanoma cell line [AID39, Type: confirmatory]
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25
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the PC-3 Prostate cell line [AID41, Type: confirmatory]
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26
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the SF-268 Central Nervous System cell line [AID45, Type: confirmatory]
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27
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the SF-295 Central Nervous System cell line [AID47, Type: confirmatory]
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28
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line [AID49, Type: confirmatory]
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29
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the SNB-19 Central Nervous System cell line [AID53, Type: confirmatory]
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30
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the SNB-75 Central Nervous System cell line [AID55, Type: confirmatory]
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31
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the U251 Central Nervous System cell line [AID59, Type: confirmatory]
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32
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the HT29 Colon cell line [AID65, Type: confirmatory]
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33
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the COLO 205 Colon cell line [AID67, Type: confirmatory]
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34
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the HCT-15 Colon cell line [AID71, Type: confirmatory]
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35
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the KM12 Colon cell line [AID73, Type: confirmatory]
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36
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the HCC-2998 Colon cell line [AID77, Type: confirmatory]
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37
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the HCT-116 Colon cell line [AID79, Type: confirmatory]
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38
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the SW-620 Colon cell line [AID81, Type: confirmatory]
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39
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the MCF7 Breast cell line [AID83, Type: confirmatory]
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40
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the MDA-MB-435 Breast cell line [AID85, Type: confirmatory]
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41
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line [AID87, Type: confirmatory]
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42
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the T-47D Breast cell line [AID91, Type: confirmatory]
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43
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the NCI/ADR-RES Breast cell line [AID93, Type: confirmatory]
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44
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the HS 578T Breast cell line [AID97, Type: confirmatory]
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45
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the OVCAR-3 Ovarian cell line [AID99, Type: confirmatory]
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46
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the IGROV1 Ovarian cell line [AID101, Type: confirmatory]
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47
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the NCI-H322M Non-Small Cell Lung cell line [AID5, Type: confirmatory]
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48
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the NCI-H226 Non-Small Cell Lung cell line [AID3, Type: confirmatory]
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49
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line [AID1, Type: confirmatory]
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50
[SID99139]
 NCI human tumor cell line growth inhibition assay. Data for the SK-OV-3 Ovarian cell line [AID103, Type: confirmatory]
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