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Enkephalin, D-Penicillamine (2,5)- (CID 104787) - Compound BioActivity Data
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BioActivity Outcomes:
Active(36)
 
 
Inconclusive(5)
 
 
Unspecified(88)
 
 
Top Targets:
7TM GPCR Srx(22)
 
 
 
 
KAZAL SLC21(11)
 
 
7TM GPCR Srsx(3)
 
 
 
ABC MTABC3 MD..(2)
 
 
ERG2 Sigma1R(1)
 
 
BioAssay Types:
Literature(126)
 
 
 
 
Confirmatory(2)
 
 
 
BioActivity Types:
IC50(27)
 
 
 
 
Ki(7)
 
 
 
EC50(6)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 126    Data Row: 129   Total Pages: 7   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103202725]
IC50 0.00014Agonist activity at delta opioid expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation [AID514365, Type: Literature]
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2
[SID103202725]
ED50 0.0009The compound was evaluated for antinociceptive potency using abdominal stretch assay in mice [AID132268, Type: Literature]
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3
[SID103202725]
EC50 0.0028Effective concentration required for in Vitro evaluation of agonist activity on mouse vas deferens preparation [AID127652, Type: confirmatory]
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4
[SID103202725]
IC50 0.0028Compound was tested for agonistic activity against the opioid receptor in electrically stimulated mouse vas deference. [AID132496, Type: Literature]Delta-type opioid receptor [gi:417418]
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5
[SID103202725]
IC50 0.0028Compound was tested for agonistic activity against the opioid receptor in electrically stimulated mouse vas deference. [AID132496, Type: Literature]Kappa-type opioid receptor [gi:464312]
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6
[SID103202725]
IC50 0.0028Compound was tested for agonistic activity against the opioid receptor in electrically stimulated mouse vas deference. [AID132496, Type: Literature]Mu-type opioid receptor [gi:1171911]
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7
[SID103202725]
IC50 0.0028Compound was tested for agonistic activity against the opioid receptor in electrically stimulated mouse vas deference. [AID132496, Type: Literature]Sigma non-opioid intracellular receptor 1 [gi:81882164]
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8
[SID103202725]
Ki 0.0032Displacement of [3H]diprenorphine from human cloned delta opioid receptor [AID307014, Type: Literature]Delta-type opioid receptor [gi:311033488]
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9
[SID103202725]
IC50 0.0037Displacement of radiolabeled DPDPE from human delta 2-type opioid receptor [AID346440, Type: Literature]
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10
[SID103202725]
ED50 0.004The compound was evaluated for antinociceptive potency using tail flick assay in mice [AID132270, Type: Literature]
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11
[SID103202725]
EC50 0.0041In vitro bioassay data to determine the effective concentration required for antagonistic activity against Opioid receptor delta 1 in functional assay, MVD [AID148502, Type: Literature]
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12
[SID103202725]
IC50 0.0041Inhibitory activity of the electrically induced smooth muscle contraction of mouse vas deferens [AID148647, Type: Literature]
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13
[SID103202725]
IC50 0.0041Ability to inhibit electrically evoked contractions of isolated muscle preparations of mouse vas deference (MVD, delta receptor) [AID226063, Type: Literature]
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14
[SID103202725]
IC50 0.00411Agonist activity was evaluated using mouse vas deferens assay. [AID138338, Type: Literature]
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15
[SID103202725]
IC50 0.0043Concentration that reduced the response by 50% by delta selective analogue was assessed in mouse vas deferens assay [AID138347, Type: Literature]
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16
[SID103202725]
IC50 0.0051Agonist activity was evaluated in guinea pig ileum (GPI) preparations at Opioid receptor delta 1 [AID148516, Type: Literature]
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17
[SID103202725]
IC50 0.00581Inhibitory concentration required for 50 percent inhibition of opioid receptor delta 1 induced contractions in mouse vas deferens (MVD) smooth muscle contraction assays [AID148651, Type: Literature]
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18
[SID103202725]
IC50 0.00581Inhibitory potency was evaluated using electrically induced smooth muscle contractions of mouse vas deferens (MVD). [AID132842, Type: Literature]
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19
[SID103202725]
ED50 0.00681Agonist activity at human delta opioid receptor expressed in HEK293 cells by [35S]GTP binding assay [AID714444, Type: Literature]Delta-type opioid receptor [gi:311033488]
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20
[SID103202725]
EC50 0.0129In Vitro evaluation for the potency for inhibiting the contraction of the electrically stimulated isolated mouse vas deferens [AID127788, Type: Literature]
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