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Enkephalin, D-Penicillamine (2,5)- (CID 104787) - Compound BioActivity Data
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BioActivity Outcomes:
Active(110)
 
 
Inactive(1)
 
 
Inconclusive(7)
 
 
Unspecified(98)
 
 
Top Targets:
7TM GPCR Srx(44)
 
 
 
 
KAZAL SLC21(11)
 
 
7TM GPCR Srsx(5)
 
 
 
ABC MTABC3 MD..(2)
 
 
ERG2 Sigma1R(1)
 
 
BioAssay Types:
Literature(200)
 
 
 
 
 
BioActivity Types:
IC50(78)
 
 
 
 
 
Ki(32)
 
 
 
EC50(17)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 213    Data Row: 216   Total Pages: 5   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103202725]
IC50 0.00014Agonist activity at delta opioid expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation [AID514365, Type: Literature]
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2
[SID103202725]
IC50 0.00063Binding affinity against rat Opioid receptor delta 1 expressed in CHO cells determined by competitive inhibition of 1 nM [3H]DPDPE. [AID149403, Type: Literature]Delta-type opioid receptor [gi:464311]
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3
[SID103202725]
ED50 0.0009The compound was evaluated for antinociceptive potency using abdominal stretch assay in mice [AID132268, Type: Literature]
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4
[SID103202725]
IC50 0.00112Displacement of [125I]deltorphin 2 from human recombinant delta opioid receptor expressed in HEK cell membranes [AID286936, Type: Literature]Delta-type opioid receptor [gi:311033488]
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5
[SID103202725]
IC50 0.00112Displacement of [125I]deltorphin 2 from human recombinant delta opioid receptor expressed in HEK293 cells [AID378465, Type: Literature]Delta-type opioid receptor [gi:311033488]
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6
[SID103202725]
IC50 0.0012Displacement of [125I]deltorphin 2 from human recombinant delta opioid receptor expressed in HEK cell membrane [AID286239, Type: Literature]Delta-type opioid receptor [gi:311033488]
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7
[SID103202725]
IC50 0.0012Displacement of [125I]deltorphin 2 from human recombinant delta opioid receptor expressed in HEK cells [AID311996, Type: Literature]Delta-type opioid receptor [gi:311033488]
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8
[SID103202725]
IC50 0.0012Displacement of [3H]deltorphin-2 from human delta opioid receptor expressed in HEK293 cell membrane [AID480387, Type: Literature]Delta-type opioid receptor [gi:311033488]
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9
[SID103202725]
Ki 0.00124Displacement of [3H]Cl-DPDPE from human DOP receptor expressed in CHO cells after 60 mins by scintillation counting [AID621888, Type: Literature]Delta-type opioid receptor [gi:311033488]
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10
[SID103202725]
EC50 0.0013Stimulation of [35S]GTP-gamma-S, binding at human recombinant Opioid receptor delta 1 transfected into CHO cells. [AID148070, Type: Literature]
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11
[SID103202725]
Ki 0.00139Displacement of [125I]-IBNtxA from DOR-1 expressed in CHO cells [AID603172, Type: Literature]
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12
[SID103202725]
EC50 0.00158Agonist activity at human delta opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding [AID554166, Type: Literature]Delta-type opioid receptor [gi:311033488]
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13
[SID103202725]
EC50 0.0016Agonist activity at human delta opioid receptor expressed in HN9.10 cells assessed by [35S]GTP-gamma-S binding assay [AID288855, Type: Literature]Delta-type opioid receptor [gi:311033488]
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14
[SID103202725]
EC50 0.0016Activity against [35S]GTP-gamma-S binding to human delta opioid receptor expressed in HN9.10 cells [AID264437, Type: Literature]Delta-type opioid receptor [gi:311033488]
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15
[SID103202725]
EC50 0.0016Agonist activity at human delta opioid receptor expressed in mouse HN9.10 cell membrane by [35S]GTPgamma binding assay [AID422082, Type: Literature]Delta-type opioid receptor [gi:311033488]
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16
[SID103202725]
EC50 0.0016Agonist activity at human delta opioid receptor by [35S]GTP-gamma-S binding assay [AID320360, Type: Literature]Delta-type opioid receptor [gi:311033488]
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17
[SID103202725]
EC50 0.0016Agonist activity at human delta opioid receptor expressed in mouse HN9.10 cells by [35S]GTPgammaS binding assay [AID391169, Type: Literature]Delta-type opioid receptor [gi:311033488]
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18
[SID103202725]
EC50 0.0016Inhibition of [35S]GTP-gamma-S binding to human delta opioid receptor expressed in CHO cells [AID261096, Type: Literature]Delta-type opioid receptor [gi:311033488]
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19
[SID103202725]
IC50 0.0016Binding affinity was measured against Opioid receptor delta 1 using [3H]p-Cl-DPDPE as radioligand. [AID149405, Type: Literature]
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20
[SID103202725]
IC50 0.0016Binding affinity towards Opioid receptor delta 1 using [3H]- [p-CIPhe4] DPDPE as radioligand [AID147813, Type: Literature]
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21
[SID103202725]
IC50 0.0016Compound was evaluated for the binding affinity in comparison with [3H][p-Cl-Phe4]-DPDPE (opioid receptor delta selective ligand) [AID149336, Type: Literature]
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22
[SID103202725]
IC50 0.0016Binding affinity opioid receptor [AID148521, Type: Literature]
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23
[SID103202725]
Ki 0.0017Displacement of [3H]C1-DPDPE from human recombinant Opioid receptor delta 1 on CHO cell membranes. [AID148220, Type: Literature]
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24
[SID103202725]
Ki 0.00177Displacement of [125I]-IBNalA from DOR-1 expressed in CHO cells [AID603173, Type: Literature]
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25
[SID103202725]
IC50 0.0018Inhibitory concentration was determined against delta-opioid receptor using [3H]- DPDPE radioligand [AID149748, Type: Literature]
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26
[SID103202725]
IC50 0.0018Tested for inhibitory concentration against [3H]DPDPE binding at sites of delta-opioid receptor in guinea pig brain membrane [AID149749, Type: Literature]
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27
[SID103202725]
Ki 0.0022In vitro potency was measured against human Opioid receptor delta 1 [AID148252, Type: Literature]
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28
[SID103202725]
Ki 0.0022Inhibition of binding of [3H]diprenorphine to cloned human Opioid receptor delta 1 expressed in CHO cell membrane;Range is between (1-3.9) [AID148365, Type: Literature]
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29
[SID103202725]
IC50 0.0025Inhibitory potency against Opioid receptor delta 1 was determined in electrically induced smooth muscle contractions of mouse vas deferens (MVD) [AID148652, Type: Literature]
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30
[SID103202725]
IC50 0.00265Compound is tested in vitro in mouse vas deferens (MVD) assay mediated by Opioid receptor delta 1 [AID148524, Type: Literature]
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31
[SID103202725]
Ki 0.00272Displacement of [3H]DPDPE from Sprague-Dawley rat delta opioid receptor by liquid scintillation counting [AID514360, Type: Literature]Delta-type opioid receptor [gi:464311]
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32
[SID103202725]
IC50 0.0028Compound was tested for agonistic activity against the opioid receptor in electrically stimulated mouse vas deference. [AID132496, Type: Literature]Kappa-type opioid receptor [gi:464312]
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33
[SID103202725]
IC50 0.0028Compound was tested for agonistic activity against the opioid receptor in electrically stimulated mouse vas deference. [AID132496, Type: Literature]Delta-type opioid receptor [gi:417418]
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34
[SID103202725]
IC50 0.0028Compound was tested for agonistic activity against the opioid receptor in electrically stimulated mouse vas deference. [AID132496, Type: Literature]Mu-type opioid receptor [gi:1171911]
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35
[SID103202725]
IC50 0.0028Compound was tested for agonistic activity against the opioid receptor in electrically stimulated mouse vas deference. [AID132496, Type: Literature]Sigma non-opioid intracellular receptor 1 [gi:81882164]
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36
[SID103202725]
EC50 0.0028Effective concentration required for in Vitro evaluation of agonist activity on mouse vas deferens preparation [AID127652, Type: other]
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37
[SID103202725]
Ki 0.0029Binding affinity towards Opioid receptor delta 1 [AID149481, Type: Literature]
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38
[SID103202725]
Ki 0.00295Binding affinity against opioid receptor by displacing radioligand [3H]DPDPE [AID149066, Type: Literature]
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39
[SID103202725]
IC50 0.003Binding potency of compound in competition with [3H]DPDPE for Opioid receptor delta 1 tested in rat brain membrane [AID149406, Type: Literature]
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40
[SID103202725]
IC50 0.0035Binding activity against human Opioid receptor delta 1 using [3H]DPDPE as a radioligand [AID148074, Type: Literature]
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41
[SID103202725]
IC50 0.0037Displacement of radiolabeled DPDPE from human delta 2-type opioid receptor [AID346440, Type: Literature]
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42
[SID103202725]
Ki 0.00398Compound was tested for the inhibition of [3H]- [D-Pen2, D-Pen5]-enkephalin (DPDPE) binding to Opioid receptor delta 1 in guinea pig brain homogenates [AID149919, Type: Literature]
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43
[SID103202725]
Ki 0.00398Binding affinity against Opioid receptor delta 1 in guinea pig brain homogenates, using [3H]DPDPE as radioligand. [AID149770, Type: Literature]
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44
[SID103202725]
ED50 0.004The compound was evaluated for antinociceptive potency using tail flick assay in mice [AID132270, Type: Literature]
View
45
[SID103202725]
IC50 0.004Inhibitory activity against forskolin-stimulated cAMP production in chinese hamster ovary cells expressing Opioid receptor delta 1 [AID149507, Type: Literature]Delta-type opioid receptor [gi:464311]
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46
[SID103202725]
IC50 0.0041Compound was evaluated for its inhibitory potency against opioid receptor delta of Mouse vas deferens [AID149205, Type: Literature]
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47
[SID103202725]
EC50 0.0041Effective concentration was measured towards delta opioid receptor using mouse vas deferens(MVD, delta) bioassay in vitro [AID148501, Type: Literature]
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48
[SID103202725]
EC50 0.0041In vitro bioassay data to determine the effective concentration required for antagonistic activity against Opioid receptor delta 1 in functional assay,MVD [AID148502, Type: Literature]
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49
[SID103202725]
IC50 0.0041Inhibitory activity measured against Opioid receptor delta 1 using mouse vas deference assay (MVD). [AID148646, Type: Literature]
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50
[SID103202725]
IC50 0.0041Inhibitory activity of the electrically induced smooth muscle contraction of mouse vas deferens [AID148647, Type: Literature]
View