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BioActivity Data for Compound NSC-747261 (CID 10411334)

BioActivity Outcomes:
Active(13)
 
 
Inactive(64)
 
 
Inconclusive(24)
 
 
Unspecified(61)
 
 
Top Targets:
NR LBD PPAR(8)
 
 
 
NR LBD AR(7)
 
 
 
 
NR LBD ER(7)
 
 
 
NR LBD Fxr(4)
 
 
NR LBD GR(4)
 
 
 
BioAssay Types:
Confirmatory(74)
 
 
 
 
 
Literature(59)
 
 
Summary(29)
 
 
 
 
BioAssay Categories:
Biochemical(2)
 
 
Toxicity(6)
 
 
 
Cell-based(59)
 
 
BioActivity Types:
Potency(95)
 
 
 
 
IC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 162    Data Row: 162   Total Pages: 9   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144209847]
Potency-Replicate_1 2.7334qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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2
[SID144209847]
AR Potency (uM) 3.18689qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line: Summary [AID743054, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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3
[SID144209847]
Potency-Replicate_1 3.861qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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4
[SID144209847]
Potency-Replicate_1 4.3321qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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5
[SID144209847]
Potency-Replicate_1 6.1193qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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6
[SID144209847]
Potency-Replicate_1 10.8818qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID743202, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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7
[SID144209847]
Ratio Potency (uM) 11.3075qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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8
[SID144209847]
Potency-Replicate_1 27.3338qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line - cell viability counter screen [AID743041, Type: confirmatory]
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9
[SID144209847]
Potency-Replicate_1 30.669qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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10
[SID144209847]
TR Potency (uM) 46.7771qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway: Summary [AID743067, Type: summary]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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11
[SID144209847]
Potency-Replicate_1 49.0321qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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12
[SID144209847]
Antagonist Potency (uM) 56.6717qHTS assay to identify small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway: Summary [AID1159523, Type: summary]RAR-related orphan receptor gamma [Mus musculus] [gi:15928672]
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13
[SID144209847]
Potency-Replicate_1 61.1927qHTS assay to identify small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID1159521, Type: confirmatory]RAR-related orphan receptor gamma [Mus musculus] [gi:15928672]
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14
[SID103718474]
IC50 250Inhibition of HIV1 recombinant integrase strand transfer activity using [32P]-radiolabeled full-length DNA as substrate after 1 hr by densitometric analysis [AID1117866, Type: confirmatory]Integrase [gi:82312013]
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15
[SID103718474]
IC50 333Inhibition of HIV1 recombinant integrase 3' processing activity using [32P]-radiolabeled full-length DNA as substrate after 1 hr by densitometric analysis [AID1117864, Type: confirmatory]Integrase [gi:82312013]
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16
[SID103718474]
Anticancer activity against human SNB19 cells assessed cell growth at 10 uM after 48 hrs by sulforhodamine B assay relative to control [AID455635, Type: Literature]
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17
[SID103718474]
Anticancer activity against human SF295 cells assessed cell growth at 10 uM after 48 hrs by sulforhodamine B assay relative to control [AID455633, Type: Literature]
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18
[SID103718474]
Anticancer activity against human SW620 cells assessed cell growth at 10 uM after 48 hrs by sulforhodamine B assay relative to control [AID455631, Type: Literature]
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19
[SID103718474]
Anticancer activity against human HCT15 cells assessed cell growth at 10 uM after 48 hrs by sulforhodamine B assay relative to control [AID455628, Type: Literature]
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20
[SID103718474]
Anticancer activity against human HCC2998 cells assessed cell growth at 10 uM after 48 hrs by sulforhodamine B assay relative to control [AID455626, Type: Literature]
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