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propionic acid (CID 1032) - Compound BioActivity Data
.
BioActivity Outcomes:
Inactive(11)
 
 
Unspecified(22)
 
 
Top Targets:
MFS(3)
 
 
PolY Pol IV k..(2)
 
 
NT POLXc(2)
 
 
BioAssay Types:
Literature(32)
 
 
 
BioActivity Types:
Ki(2)
 
 
IC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 33    Data Row: 33   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103176199]
LD50 10Cytotoxicity against mouse RAW264.7 cells [AID627981, Type: Literature]
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2
[SID103176199]
IC50 130Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production [AID454554, Type: Literature]Free fatty acid receptor 2 [gi:3122160]
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3
[SID103176199]
Ki 281.838Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr [AID360149, Type: Literature]Solute carrier family 22 member 20 [gi:56404586]
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4
[SID103176199]
IC50 4000Inhibition of cell growth against human myeloid leukemia K562(S) cells [AID95143, Type: Literature]
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5
[SID103176199]
Ki 8128.31Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hr [AID360150, Type: Literature]Solute carrier family 22 member 6 [gi:81901833]
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6
[SID103176199]
Cytotoxicity against mouse RAW264.7 cells at 5 uM [AID627980, Type: Literature]
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7
[SID103176199]
TP_TRANSPORTER: uptake of Propionic acid at a concentration of 7uM in MCT1-expressing MDA-MB231 cells [AID679716, Type: other]Monocarboxylate transporter 1 [gi:1709076]
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8
[SID103176199]
Agonist activity at human FFA2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP production relative to acetate [AID454564, Type: Literature]Free fatty acid receptor 2 [gi:3122160]
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9
[SID103176199]
Compound was evaluated for inhibitory activity against Saccharomyces cerevisiae; 3.2-4 [AID200327, Type: Literature]
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10
[SID103176199]
Lipophilicity determined as logarithm of the partition coefficient in the alkane/water system [AID237685, Type: Literature]
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11
[SID103176199]
Dissociation constant, pKa of the compound [AID342464, Type: Literature]
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12
[SID103176199]
Ratio of pKi for mouse Oat1 expressed in Xenopus oocytes to pKi for mouse Oat6 expressed in Xenopus oocytes [AID360151, Type: Literature]
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13
[SID103176199]
Inhibition of HDAC in human Hela cells nuclear extracts assessed as residual activity at 500 uM by fluorimetric assay [AID447578, Type: Literature]
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14
[SID103176199]
Toxicity in po dosed mouse [AID498775, Type: Literature]
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15
[SID103176199]
Partition coefficient (logP) [AID23251, Type: Literature]
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16
[SID103176199]
Partition coefficient (logP) (benzene) [AID23252, Type: Literature]
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17
[SID103176199]
Partition coefficient (logP) (carbon tetrachloride) [AID23253, Type: Literature]
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18
[SID103176199]
Partition coefficient (logP) (chloroform) [AID23254, Type: Literature]
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19
[SID103176199]
Partition coefficient (logP) (ether) [AID23255, Type: Literature]
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20
[SID103176199]
Partition coefficient (logP) (hexane) [AID23256, Type: Literature]
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21
[SID103176199]
Compound was evaluated for inhibitory activity against Candida albicans; 3.2-4 [AID45137, Type: Literature]
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22
[SID103176199]
Compound was evaluated for erythroid induction of benzidine-positive K562 cells at concentration 4 mM after 9 day induction period [AID94968, Type: Literature]
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23
[SID103176199]
Inhibition of calf DNA polymerase alpha using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substrate at 10 uM after 60 mins [AID627874, Type: Literature]
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24
[SID103176199]
Inhibition of histidine-tagged human DNA polymerase gamma using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substrate at 10 uM after 60 mins [AID627875, Type: Literature]
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25
[SID103176199]
LD50 Cytotoxicity against human HCT116 cells by WST-1 assay [AID627976, Type: Literature]
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26
[SID103176199]
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha secretion at 5 uM treated 30 mins before LPS challenge measured after 24 hrs by ELISA [AID627979, Type: Literature]
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27
[SID103176199]
Inhibition of recombinant His-tagged human DNA polymerase lambda using bovine deoxyribonuclease 1-treated DNA and dNTP as the DNA template-primer and nucleotide substrate at 10 uM after 60 mins [AID627880, Type: Literature]DNA polymerase lambda [gi:17367126]
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28
[SID103176199]
Inhibition of recombinant His-tagged human DNA polymerase lambda using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substrate at 10 uM after 60 mins [AID628060, Type: Literature]DNA polymerase lambda [gi:17367126]
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29
[SID103176199]
Antiinflammatory activity in mouse assessed as inhibition of TPA-induced mouse ear edema at 500 ug/ear administered 30 mins before TPA challenge measured after 7 hrs relative to untreated control [AID627982, Type: Literature]
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30
[SID103176199]
Inhibition of calf DNA polymerase alpha using bovine deoxyribonuclease 1-treated DNA and dNTP as the DNA template-primer and nucleotide substrate at 10 uM after 60 mins [AID627877, Type: Literature]
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31
[SID103176199]
Inhibition of histidine-tagged human DNA polymerase gamma using bovine deoxyribonuclease 1-treated DNA and dNTP as the DNA template-primer and nucleotide substrate at 10 uM after 60 mins [AID627878, Type: Literature]
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32
[SID103176199]
Inhibition of C-terminal His6-tagged human DNA polymerase kappa (amino acids 1 to 560) using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substrate at 10 uM after 60 mins [AID627876, Type: Literature]DNA polymerase kappa [gi:59798438]
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33
[SID103176199]
Inhibition of C-terminal His6-tagged human DNA polymerase kappa (amino acids 1 to 560) using bovine deoxyribonuclease 1-treated DNA and dNTP as the DNA template-primer and nucleotide substrate at 10 uM after 60 mins [AID627879, Type: Literature]DNA polymerase kappa [gi:59798438]
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