diphosphoric acid (CID 1023) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(15)
 
 
Inactive(135)
 
 
Inconclusive(27)
 
 
Unspecified(5)
 
 
Top Targets:
p450(10)
 
 
 
Firefly Luc l..(3)
 
 
PTB RGS12(2)
 
 
Menin(2)
 
 
NR LBD GR(2)
 
 
BioAssay Types:
Confirmatory(89)
 
 
 
 
Literature(73)
 
 
 
 
 
Screening(3)
 
 
BioActivity Types:
Potency(64)
 
 
 
 
Ki(3)
 
 
IC50(2)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 115    Data Row: 182   Total Pages: 4   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID4253134]
Potency 1.8106S16 Schwann cell PMP22 intronic element firefly luciferase assay [AID624032, Type: confirmatory]Pmp22 gene product [Rattus norvegicus] [gi:8393992]
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2
[SID4253134]
Potency 3.7933Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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3
[SID103760657]
IC50 181Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins [AID318594, Type: Literature]Farnesyl pyrophosphate synthase [gi:215274250]
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4
[SID103760657]
IC50 181Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins [AID318594, Type: Literature]Farnesyl pyrophosphate synthase [gi:215274250]
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5
[SID103760657]
IC50 243Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 [AID318593, Type: Literature]Farnesyl pyrophosphate synthase [gi:215274250]
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6
[SID103760657]
IC50 243Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 [AID318593, Type: Literature]Farnesyl pyrophosphate synthase [gi:215274250]
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7
[SID103760657]
 Inhibition of HIV1 reverse transcriptase p66/p51 mediated DNA synthesis using polypurine tract primer assessed as DNA bands at position +2 by polyacrylamide gel electrophoresis [AID360400, Type: Literature]
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8
[SID103760657]
 Inhibition of HIV1 reverse transcriptase p66/p51 mediated DNA synthesis using polypurine tract primer assessed as DNA bands at position +11 by polyacrylamide gel electrophoresis [AID360401, Type: Literature]
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9
[SID103760657]
 Inhibition of HIV1 reverse transcriptase p66/p51 mediated DNA synthesis using polypurine tract primer assessed as DNA bands at position +15 by polyacrylamide gel electrophoresis [AID360402, Type: Literature]
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10
[SID103760657]
 Increase in excision and rescue of RNA synthesis in Hepatitis C virus harboring wild-type NS5B gene at 320 uM [AID525264, Type: Literature]
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11
[SID103760657]
 Increase in excision and rescue of RNA synthesis in Hepatitis C virus harboring NS5B P156L mutant gene at 320 uM [AID525266, Type: Literature]
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12
[SID103760657]
 Increase in excision and rescue of RNA synthesis in Hepatitis C virus harboring NS5B G152E mutant gene at 320 uM [AID525267, Type: Literature]
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13
[SID10322006]
 Activity Assay, Human PTPN5 [AID400, Type: other]protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) isoform a [Homo sapiens] [gi:90652853]
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14
[SID10322006]
 Activity Assay, Human PTPN5 [AID400, Type: other]protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) isoform a [Homo sapiens] [gi:90652853]
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15
[SID85209242]
 Ligands of peptide (Class A) GPCRs [AID2063, Type: other]
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16
[SID4253134]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_52, Type: Literature]
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17
[SID4253134]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_3, Type: Literature]
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18
[SID4253134]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_19, Type: Literature]
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19
[SID103760657]
Ki 240Binding affinity against ornithine transcarbamoylase (OTC) produced by Streptococcus faecalis The buffer taken for this study is 50 mM maleate, 0.5 mM EDTA at pH 6.0. [AID151019, Type: Literature]
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20
[SID103760657]
Ki 890Binding affinity against ornithine transcarbamoylase (OTC) produced by Streptococcus faecalis The buffer taken for this study is 50 mM Tris.HCl, 0.5 mM EDTA at pH 7.0. [AID151018, Type: Literature]
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21
[SID103760657]
Ki 2000Binding affinity against ornithine transcarbamoylase (OTC) produced by Streptococcus faecalis The buffer taken for this study is 50 mM Tris.HCl, 0.5 mM EDTA at pH 8.0. [AID151017, Type: Literature]
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22
[SID4253134]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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23
[SID4253134]
 Cytochrome panel assay with activity outcomes [AID1851, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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24
[SID4253134]
 Cytochrome panel assay with activity outcomes [AID1851, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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25
[SID4253134]
 Cytochrome panel assay with activity outcomes [AID1851_1, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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26
[SID4253134]
 Cytochrome panel assay with activity outcomes [AID1851_1, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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27
[SID4253134]
Potency qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 9 [Homo sapiens] [gi:13699818]
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28
[SID4253134]
Potency qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 9 [Homo sapiens] [gi:13699818]
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29
[SID4253134]
Potency qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 9 [Homo sapiens] [gi:13699818]
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30
[SID4253134]
Potency qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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31
[SID4253134]
Potency qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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32
[SID4253134]
Potency qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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33
[SID4253134]
Potency qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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34
[SID4253134]
Potency qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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35
[SID4253134]
Potency qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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36
[SID50108488]
Potency qHTS Assay for Inhibitors of Influenza NS1 Protein Function [AID2326, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/WSN/1933(H1N1))] [gi:194352380]
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37
[SID50108488]
Potency qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent) [AID1476, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
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38
[SID50108488]
Potency qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent) [AID1478, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
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39
[SID50108488]
Potency qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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40
[SID50108488]
Potency qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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41
[SID4253134]
Potency qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase) [AID1452, Type: confirmatory]arachidonate 12-lipoxygenase, 12S-type [Homo sapiens] [gi:154426292]
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42
[SID4253134]
Potency qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase) [AID1452, Type: confirmatory]arachidonate 12-lipoxygenase, 12S-type [Homo sapiens] [gi:154426292]
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43
[SID4253134]
Potency qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase) [AID887, Type: confirmatory]15-lipoxygenase [Homo sapiens] [gi:1832253]
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44
[SID4253134]
Potency qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase) [AID887, Type: confirmatory]15-lipoxygenase [Homo sapiens] [gi:1832253]
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45
[SID4253134]
Potency qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2) [AID881, Type: confirmatory]Arachidonate 15-lipoxygenase B [gi:317373425]
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46
[SID50108488]
Potency qHTS Assay for Compounds that Induce Erasure of Genomic Imprints [AID1948, Type: confirmatory]
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47
[SID4253134]
Potency S16 Schwann cell viability assay (CellTiter-Glo assay) [AID624031, Type: confirmatory]
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48
[SID4253134]
Potency S16 Schwann cell PMP22 intronic element beta-lactamase assay [AID624044, Type: confirmatory]Pmp22 gene product [Rattus norvegicus] [gi:8393992]
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49
[SID4253134]
 JNK3 AlphaScreen Assay [AID530, Type: confirmatory]Mitogen-activated protein kinase 10 (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase [gi:2499604]
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50
[SID4253134]
Potency A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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