benzimidazole-urea, 34 (CID 10186269) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(3)
 
 
Inactive(2)
 
 
Inconclusive(1)
 
 
Top Targets:
PTKc Tie2(2)
 
 
Firefly Luc l..(1)
 
 
PTKc VEGFR2(1)
 
 
BioAssay Types:
Literature(3)
 
 
Confirmatory(3)
 
 
 
BioActivity Types:
IC50(3)
 
 
Potency(3)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 6    Data Row: 6   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103527621]
IC50 0.01Inhibition of GST-tagged human recombinant VEGFR2 expressed in baculovirus [AID297392, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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2
[SID103527621]
IC50 0.01Inhibition of GST-tagged human recombinant VEGFR2 expressed in baculovirus [AID297392, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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3
[SID103527621]
IC50 0.01Inhibition of GST-tagged human recombinant TIE2 expressed in baculovirus [AID297391, Type: Literature]Angiopoietin-1 receptor [gi:218511853]
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4
[SID103527621]
IC50 0.01Inhibition of GST-tagged human recombinant TIE2 expressed in baculovirus [AID297391, Type: Literature]Angiopoietin-1 receptor [gi:218511853]
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5
[SID103527621]
IC50 0.076Inhibition of TIE-2/c-fms chimeric protein expressed in mouse 3T3 cells assessed as autophosphorylation level by ELISA [AID297393, Type: Literature]Angiopoietin-1 receptor [gi:218511853]
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6
[SID103527621]
IC50 0.076Inhibition of TIE-2/c-fms chimeric protein expressed in mouse 3T3 cells assessed as autophosphorylation level by ELISA [AID297393, Type: Literature]Angiopoietin-1 receptor [gi:218511853]
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7
[SID124350135]
Potency 0.0006qHTS Assay for Inhibitors of Sea Pansy Luciferase from the GSK Published Protein Kinase Inhibitor Set [AID652015, Type: confirmatory]Renilla-luciferin 2-monooxygenase (EC 1.13.12.5) - sea pansy (Renilla reniformis) (fragment) [gi:84399]
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8
[SID124350135]
Potency qHTS Assay for Inhibitors of Firefly Luciferase from the GSK Published Protein Kinase Inhibitor Set [AID652016, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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9
[SID124350135]
Potency 4.9917qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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