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5-((5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl)-N-(2-hydroxy-3-morpholin-4-ylpropyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (CID 10138259) - Compound BioActivity Data
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BioActivity Outcomes:
Active(479)
 
 
Inactive(168)
 
 
Unspecified(298)
 
 
Top Targets:
PKc(109)
 
 
 
 
PKc like(81)
 
 
 
 
STKc AGC(44)
 
 
 
 
PTKc Abl(30)
 
 
 
 
PTKc EGFR(23)
 
 
 
 
BioAssay Types:
Literature(762)
 
 
 
Confirmatory(182)
 
 
 
BioActivity Types:
Kd(761)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 763    Data Row: 945   Total Pages: 19   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID131277755]
Kd 0.00025Binding constant for KIT(V559D,V654A) kinase domain [AID435802, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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2
[SID131277755]
Kd 0.00025Binding constant for KIT(V559D,V654A) kinase domain [AID624793, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View
3
[SID131277755]
Kd 0.00029Binding constant for KIT(L576P) kinase domain [AID624790, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View
4
[SID131277755]
Kd 0.00029Binding constant for PDGFRB kinase domain [AID435926, Type: Literature]Platelet-derived growth factor receptor beta [gi:129890]
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5
[SID131277755]
Kd 0.00029Binding constant for PDGFRB kinase domain [AID624875, Type: Literature]Platelet-derived growth factor receptor beta [gi:129890]
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6
[SID131277755]
Kd 0.00051Binding constant for KIT(V559D) kinase domain [AID624791, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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7
[SID131277755]
Kd 0.00051Binding constant for KIT(V559D) kinase domain [AID435167, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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8
[SID131277755]
Kd 0.00054Binding constant for FLT3 kinase domain [AID435799, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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9
[SID131277755]
Kd 0.00054Binding constant for FLT3 kinase domain [AID624934, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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10
[SID131277755]
Kd 0.00056Binding constant for KIT(V559D,T670I) kinase domain [AID624792, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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11
[SID131277755]
Kd 0.00056Binding constant for KIT(V559D,T670I) kinase domain [AID435675, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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12
[SID131277755]
Kd 0.00068Binding constant for KIT kinase domain [AID624786, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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13
[SID131277755]
Kd 0.00068Binding constant for KIT kinase domain [AID435410, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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14
[SID131277755]
Kd 0.00068Binding affinity to human KIT incubated for 1 hr by kinase binding assay [AID599957, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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15
[SID131277755]
Kd 0.0007Binding constant for FLT3(K663Q) kinase domain [AID624938, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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16
[SID131277755]
Kd 0.0011Binding constant for PDGFRA kinase domain [AID625034, Type: Literature]Platelet-derived growth factor receptor alpha [gi:129892]
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17
[SID131277755]
Kd 0.0011Binding constant for PDGFRA kinase domain [AID435827, Type: Literature]Platelet-derived growth factor receptor alpha [gi:129892]
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18
[SID131277755]
Kd 0.0018Binding constant for FLT3(ITD) kinase domain [AID624937, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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19
[SID131277755]
Kd 0.0018Binding constant for FLT3(ITD) kinase domain [AID435310, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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20
[SID131277755]
Kd 0.0023Binding constant for VEGFR2 kinase domain [AID624860, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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21
[SID131277755]
Kd 0.0023Binding constant for VEGFR2 kinase domain [AID435327, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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22
[SID131277755]
Kd 0.0036Binding constant for CSF1R kinase domain [AID624995, Type: Literature]Macrophage colony-stimulating factor 1 receptor [gi:547770]
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23
[SID131277755]
Kd 0.0036Binding constant for CSF1R kinase domain [AID435280, Type: Literature]Macrophage colony-stimulating factor 1 receptor [gi:547770]
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24
[SID131277755]
Kd 0.0037Binding constant for HUNK kinase domain [AID625084, Type: Literature]Hormonally up-regulated neu tumor-associated kinase [gi:9973393]
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25
[SID131277755]
Kd 0.0047Binding constant for FLT1 kinase domain [AID624853, Type: Literature]Vascular endothelial growth factor receptor 1 [gi:143811474]
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26
[SID131277755]
Kd 0.0047Binding constant for FLT1 kinase domain [AID435429, Type: Literature]Vascular endothelial growth factor receptor 1 [gi:143811474]
View
27
[SID131277755]
Kd 0.0054Binding constant for FLT3(N841I) kinase domain [AID435162, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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28
[SID131277755]
Kd 0.0054Binding constant for FLT3(N841I) kinase domain [AID624939, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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29
[SID131277755]
Kd 0.0061Binding constant for FLT3(D835Y) kinase domain [AID435407, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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30
[SID131277755]
Kd 0.0061Binding constant for FLT3(D835Y) kinase domain [AID624936, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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31
[SID131277755]
Kd 0.0063Binding constant for FLT3(D835H) kinase domain [AID624935, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
View
32
[SID131277755]
Kd 0.0063Binding constant for FLT3(D835H) kinase domain [AID435406, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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33
[SID131277755]
Kd 0.0082Binding constant for STK35 kinase domain [AID624711, Type: Literature]Serine/threonine-protein kinase 35 [gi:292495039]
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34
[SID131277755]
Kd 0.012Binding constant for YSK4 kinase domain [AID625136, Type: Literature]Mitogen-activated protein kinase kinase kinase 19 [gi:74755104]
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35
[SID131277755]
Kd 0.014Binding constant for RET(V804M) kinase domain [AID625124, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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36
[SID131277755]
Kd 0.015Binding constant for HPK1 kinase domain [AID624816, Type: Literature]Mitogen-activated protein kinase kinase kinase kinase 1 [gi:29427916]
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37
[SID131277755]
Kd 0.015Binding constant for MAP4K1 kinase domain [AID435431, Type: Literature]Mitogen-activated protein kinase kinase kinase kinase 1 [gi:29427916]
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38
[SID131277755]
Kd 0.018Binding constant for RET(V804L) kinase domain [AID625123, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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39
[SID131277755]
Kd 0.024Binding constant for RET(M918T) kinase domain [AID625122, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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40
[SID131277755]
Kd 0.024Binding constant for RET(M918T) kinase domain [AID435323, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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41
[SID131277755]
Kd 0.024Binding constant for DRAK1 kinase domain [AID435790, Type: Literature]Serine/threonine-protein kinase 17A [gi:317373279]
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42
[SID131277755]
Kd 0.024Binding constant for DRAK1 kinase domain [AID624968, Type: Literature]Serine/threonine-protein kinase 17A [gi:317373279]
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43
[SID131277755]
Kd 0.026Binding constant for IRAK1 kinase domain [AID624837, Type: Literature]Interleukin-1 receptor-associated kinase 1 [gi:8928535]
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44
[SID131277755]
Kd 0.027Binding constant for BIKE kinase domain [AID435275, Type: Literature]BMP-2-inducible protein kinase [gi:34222653]
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45
[SID131277755]
Kd 0.027Binding constant for BIKE kinase domain [AID625109, Type: Literature]BMP-2-inducible protein kinase [gi:34222653]
View
46
[SID131277755]
Kd 0.032Binding constant for SgK085 kinase domain [AID435691, Type: Literature]Myosin light chain kinase family member 4 [gi:118573873]
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47
[SID131277755]
Kd 0.032Binding constant for MYLK4 kinase domain [AID624809, Type: Literature]Myosin light chain kinase family member 4 [gi:118573873]
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48
[SID131277755]
Kd 0.034Binding constant for FER kinase domain [AID625010, Type: Literature]Tyrosine-protein kinase Fer [gi:97536202]
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49
[SID131277755]
Kd 0.034Binding constant for FER kinase domain [AID435160, Type: Literature]Tyrosine-protein kinase Fer [gi:97536202]
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50
[SID131277755]
Kd 0.037Binding constant for RET kinase domain [AID625121, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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