pazopanib (CID 10113978) - BioAssay Data Summary for Compound
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BioActivity Outcomes:
Active(271)
 
 
Top Targets:
PTKc Kit(18)
 
 
PTKc Abl(17)
 
 
PKc(13)
 
 
ig(12)
 
 
STKc AGC(12)
 
 
BioAssay Types:
Literature(262)
 
 
Confirmatory(9)
 
 
BioActivity Types:
Kd(224)
 
 
IC50(9)
 
 
Potency(3)
 
 
SAR
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 242    Data Row: 271   Total Pages: 6   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103623548]
Kd 0.0018Binding constant for KIT(L576P) kinase domain [AID624790, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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2
[SID103623548]
Kd 0.0018Binding constant for KIT(L576P) kinase domain [AID624790, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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3
[SID103623548]
Kd 0.002Binding constant for PDGFRB kinase domain [AID435926, Type: Literature]Platelet-derived growth factor receptor beta [gi:129890]
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4
[SID103623548]
Kd 0.002Binding constant for PDGFRB kinase domain [AID624875, Type: Literature]Platelet-derived growth factor receptor beta [gi:129890]
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5
[SID103623548]
Kd 0.002Binding constant for PDGFRB kinase domain [AID435926, Type: Literature]Platelet-derived growth factor receptor beta [gi:129890]
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6
[SID103623548]
Kd 0.002Binding constant for PDGFRB kinase domain [AID624875, Type: Literature]Platelet-derived growth factor receptor beta [gi:129890]
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7
[SID103623548]
Kd 0.0023Binding constant for KIT(V559D) kinase domain [AID435167, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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8
[SID103623548]
Kd 0.0023Binding constant for KIT(V559D) kinase domain [AID624791, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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9
[SID103623548]
Kd 0.0023Binding constant for KIT(V559D) kinase domain [AID624791, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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10
[SID103623548]
Kd 0.0023Binding constant for KIT(V559D) kinase domain [AID435167, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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11
[SID103623548]
Kd 0.0028Binding constant for KIT kinase domain [AID435410, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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12
[SID103623548]
Kd 0.0028Binding affinity to human KIT incubated for 1 hr by kinase binding assay [AID599957, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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13
[SID103623548]
Kd 0.0028Binding constant for KIT kinase domain [AID624786, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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14
[SID103623548]
Kd 0.0028Binding constant for KIT kinase domain [AID435410, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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15
[SID103623548]
Kd 0.0028Binding affinity to human KIT incubated for 1 hr by kinase binding assay [AID599957, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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16
[SID103623548]
Kd 0.0028Binding constant for KIT kinase domain [AID624786, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View
17
[SID103623548]
Kd 0.0049Binding constant for PDGFRA kinase domain [AID435827, Type: Literature]Platelet-derived growth factor receptor alpha [gi:129892]
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18
[SID103623548]
Kd 0.0049Binding constant for PDGFRA kinase domain [AID625034, Type: Literature]Platelet-derived growth factor receptor alpha [gi:129892]
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19
[SID103623548]
Kd 0.0049Binding constant for PDGFRA kinase domain [AID435827, Type: Literature]Platelet-derived growth factor receptor alpha [gi:129892]
View
20
[SID103623548]
Kd 0.0049Binding constant for PDGFRA kinase domain [AID625034, Type: Literature]Platelet-derived growth factor receptor alpha [gi:129892]
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21
[SID103623548]
Kd 0.0065Binding constant for KIT(V559D,T670I) kinase domain [AID624792, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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22
[SID103623548]
Kd 0.0065Binding constant for KIT(V559D,T670I) kinase domain [AID435675, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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23
[SID103623548]
Kd 0.0065Binding constant for KIT(V559D,T670I) kinase domain [AID624792, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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24
[SID103623548]
Kd 0.0065Binding constant for KIT(V559D,T670I) kinase domain [AID435675, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View
25
[SID103623548]
Kd 0.0079Binding constant for CSF1R kinase domain [AID435280, Type: Literature]Macrophage colony-stimulating factor 1 receptor [gi:547770]
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26
[SID103623548]
Kd 0.0079Binding constant for CSF1R kinase domain [AID624995, Type: Literature]Macrophage colony-stimulating factor 1 receptor [gi:547770]
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27
[SID103623548]
Kd 0.0079Binding constant for CSF1R kinase domain [AID435280, Type: Literature]Macrophage colony-stimulating factor 1 receptor [gi:547770]
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28
[SID103623548]
Kd 0.0079Binding constant for CSF1R kinase domain [AID624995, Type: Literature]Macrophage colony-stimulating factor 1 receptor [gi:547770]
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29
[SID103623548]
IC50 0.008Inhibition of VEGF-induced VEGFR2 phosphorylation in HUVEC [AID341906, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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30
[SID103623548]
IC50 0.008Inhibition of VEGF-induced VEGFR2 phosphorylation in HUVEC [AID341906, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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31
[SID103623548]
IC50 0.01Inhibition of human GST-tagged VEGFR1 by HTRF assay [AID341894, Type: Literature]Vascular endothelial growth factor receptor 1 [gi:143811474]
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32
[SID103623548]
IC50 0.01Inhibition of human GST-tagged VEGFR1 by HTRF assay [AID341894, Type: Literature]Vascular endothelial growth factor receptor 1 [gi:143811474]
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33
[SID103623548]
Kd 0.014Binding constant for FLT1 kinase domain [AID435429, Type: Literature]Vascular endothelial growth factor receptor 1 [gi:143811474]
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34
[SID103623548]
Kd 0.014Binding constant for FLT1 kinase domain [AID624853, Type: Literature]Vascular endothelial growth factor receptor 1 [gi:143811474]
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35
[SID103623548]
Kd 0.014Binding constant for FLT1 kinase domain [AID435429, Type: Literature]Vascular endothelial growth factor receptor 1 [gi:143811474]
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36
[SID103623548]
Kd 0.014Binding constant for FLT1 kinase domain [AID624853, Type: Literature]Vascular endothelial growth factor receptor 1 [gi:143811474]
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37
[SID103623548]
Kd 0.014Binding constant for VEGFR2 kinase domain [AID435327, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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38
[SID103623548]
Kd 0.014Binding constant for VEGFR2 kinase domain [AID624860, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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39
[SID103623548]
Kd 0.014Binding constant for VEGFR2 kinase domain [AID435327, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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40
[SID103623548]
Kd 0.014Binding constant for VEGFR2 kinase domain [AID624860, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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41
[SID103623548]
Kd 0.027Binding constant for FLT4 kinase domain [AID436018, Type: Literature]Vascular endothelial growth factor receptor 3 [gi:357529070]
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42
[SID103623548]
Kd 0.027Binding constant for FLT4 kinase domain [AID624854, Type: Literature]Vascular endothelial growth factor receptor 3 [gi:357529070]
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43
[SID103623548]
Kd 0.027Binding constant for FLT4 kinase domain [AID436018, Type: Literature]Vascular endothelial growth factor receptor 3 [gi:357529070]
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44
[SID103623548]
Kd 0.027Binding constant for FLT4 kinase domain [AID624854, Type: Literature]Vascular endothelial growth factor receptor 3 [gi:357529070]
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45
[SID103623548]
IC50 0.03Inhibition of recombinant VEGFR2 after 1 hr by fluorescence polarization assay [AID538338, Type: Literature]
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46
[SID103623548]
Kd 0.03Binding constant for KIT(V559D,V654A) kinase domain [AID624793, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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47
[SID103623548]
Kd 0.03Binding constant for KIT(V559D,V654A) kinase domain [AID435802, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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48
[SID103623548]
Kd 0.03Binding constant for KIT(V559D,V654A) kinase domain [AID435802, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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49
[SID103623548]
Kd 0.03Binding constant for KIT(V559D,V654A) kinase domain [AID624793, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
View
50
[SID103623548]
IC50 0.03Inhibition of human recombinant VEGFR2 [AID341896, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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