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phenethylamine (CID 1001) - Compound BioActivity Data
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BioActivity Outcomes:
Active(34)
 
 
Inactive(480)
 
 
Unspecified(35)
 
 
Top Targets:
7tm 4(35)
 
 
 
 
Tryp SPc(11)
 
 
 
PLDc mTdp1 2(5)
 
 
CAP ED(5)
 
 
Esterase lipa..(5)
 
 
BioAssay Types:
Screening(340)
 
 
 
Confirmatory(121)
 
 
 
Literature(72)
 
 
 
 
BioActivity Types:
Potency(101)
 
 
 
IC50(16)
 
 
 
Ki(11)
 
 
 
EC50(10)
 
 
 
Kd(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 494    Data Row: 549   Total Pages: 28   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103185023]
EC50 0.04033Activation of rat wild type TAAR1 expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assay [AID1066371, Type: Literature]Trace amine-associated receptor 1 [gi:38258290]
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2
[SID103185023]
EC50 0.0473Activation of mouse TAAR1 transmembrane domain 6 Thr268(6.55)Met mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assay [AID1066368, Type: Literature]
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3
[SID103185023]
EC50 0.0586Activation of mouse TAAR1 transmembrane domain 7 Tyr287(7.39)Asn mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assay [AID1066366, Type: Literature]
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4
[SID103185023]
EC50 0.106Activation of human TAAR1 expressed in Syrian hamster AV12-664 cells co-expressing GalphaS protein assessed as accumulation of cAMP after 30 mins using cAMP XS EA/CL as substrate by luminescence method in presence of RX821002 and alprenolol [AID635295, Type: Literature]Trace amine-associated receptor 1 [gi:38258636]
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5
[SID103185023]
EC50 0.129Agonist activity at human trace amine associated receptor 1 expressed in RD-HGA16 CHO-K1 cells coexpressed with Galpha16 protein assessed as internal calcium mobilization by calcium 3 assay [AID341210, Type: Literature]Trace amine-associated receptor 1 [gi:38258636]
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6
[SID103185023]
EC50 0.1706Activation of rat TAAR1 transmembrane domain 7 Asn287(7.39)Tyr mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assay [AID1066367, Type: Literature]
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7
[SID103185023]
EC50 0.189Activation of mouse wild type TAAR1 expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assay [AID1066370, Type: Literature]Trace amine-associated receptor 1 [gi:38258626]
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8
[SID103185023]
EC50 0.209Activation of rat TAAR1 expressed in Syrian hamster AV12-664 cells assessed as accumulation of cAMP after 30 mins using cAMP XS EA/CL as substrate by luminescence method [AID635291, Type: Literature]Trace amine-associated receptor 1 [gi:38258290]
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9
[SID103185023]
EC50 0.2612Activation of rat TAAR1 transmembrane domain 6 Met268(6.55)Thr mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assay [AID1066369, Type: Literature]
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10
[SID103185023]
IC50 3Inhibitory concentration against mouse cytochrome P450 2A5 [AID241174, Type: Literature]
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11
[SID103185023]
Ki 4Displacement of [3H]clonidine from adrenergic alpha-1 receptor in Sprague-Dawley rat cortex [AID313559, Type: Literature]
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12
[SID103185023]
IC50 4.41Inhibitory concentration against human cytochrome P450 2A6 [AID241172, Type: Literature]Cytochrome P450 2A6 [gi:308153612]
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13
[SID103185023]
Kd 5.49541Affinity against 5-hydroxytryptamine receptors in rat fundus model [AID6406, Type: Literature]
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14
[SID103185023]
Kd 5.49541Affinity for 5-hydroxytryptamine receptor was determined using male Dawley rat fundus preparation [AID6407, Type: Literature]
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15
[SID103185023]
Ki 11Binding affinity against bovine trypsin [AID214878, Type: Literature]Cationic trypsin [gi:205371855]
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16
[SID103185023]
Ki 16.8Displacement of [3H]ketanserin from 5HT2A receptor expressed in NIH3T3 cells [AID389734, Type: Literature]
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17
[SID103185023]
Ki 16.8Binding affinity was performed using [3H]ketanserin as the radioligand and stably transfected NIH3T3 cells expressing the 5-hydroxytryptamine 2A receptor (GF-62 cells). [AID5354, Type: Literature]
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18
[SID103185023]
Ki 16.82Binding affinity against 5-hydroxytryptamine 2A receptor expressed NIH3T3 cells using [3H]ketanserin [AID5516, Type: Literature]5-hydroxytryptamine receptor 2A [gi:112808]
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19
[SID103185023]
Km 34.8Binding affinity to mouse SSAO [AID273100, Type: Literature]Membrane primary amine oxidase [gi:5902787]
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20
[SID46393335]
Kd 972Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Trypsin Specificity As Elucidated By Lie Calculations, X-Ray Structures And Association Constant Measurements [gi:42543835]
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