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BioAssay: AID 772306

Agonist activity at NTR1 (unknown origin) expressed in human U2OS cells coexpressing beta-arrestin by GFP reporter gene assay relative to neurotensin (8 to 13)

Title: Discovery of ML314, a Brain Penetrant Non-Peptidic beta-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor.
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 Tested Compounds
 Tested Compounds
All(34)
 
 
Unspecified(34)
 
 
 Tested Substances
 Tested Substances
All(34)
 
 
Unspecified(34)
 
 
 Related BioAssays
 Related BioAssays
AID: 772306
Data Source: ChEMBL (986353)
Depositor Category: Literature, Extracted
BioAssay Version:
Deposit Date: 2014-05-03
Modify Date: 2014-08-24

Data Table ( Complete ):           View All Data
Target
Sequence: RecName: Full=Neurotensin receptor type 1; Short=NT-R-1; Short=NTR1; AltName: Full=High-affinity levocabastine-insensitive neurotensin receptor; AltName: Full=NTRH
Description ..   
Protein Family: Olfactory receptor
Comment ..   

Gene:NTSR1     Related Protein 3D Structures     More BioActivity Data..
Tested Compounds:
Description:
Title: Discovery of ML314, a Brain Penetrant Non-Peptidic beta-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor.
(PMID: 24611085)
Categorized Comment - additional comments and annotations
From BioAssay Depositor:
Assay Type: Binding
Target Type: Target is a single protein chain
Assay Data Source: Scientific Literature
BAO: Assay Format: cell-based format
Assay Test Type: In vitro
Result Definitions
TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1Emax activity commentEmax activity commentString
2Emax standard flagEmax standard flagInteger
3Emax qualifierEmax qualifierString
4Emax published valueEmax published valueFloat%
5Emax standard valueEmax standard valueFloat%

Data Table (Concise)
Data Table ( Complete ):     View All Data
Classification
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