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BioAssay: AID 765835

Ratio of morphine EC50 to compound EC50 for human MOR

(-)-Codeine 1 was converted into previously unknown 7beta-methyl-7,8-dihydrocodeine/morphine derivatives such as 13 via classical diaxial opening of alpha-epoxide 3. Several analogs exhibited dual mu/delta-agonist activity. ..more
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 Tested Compounds
 Tested Compounds
All(1)
 
 
Unspecified(1)
 
 
 Tested Substances
 Tested Substances
All(1)
 
 
Unspecified(1)
 
 
 Related BioAssays
 Related BioAssays
AID: 765835
Data Source: ChEMBL (978253)
Depositor Category: Literature, Extracted
BioAssay Version:
Deposit Date: 2014-05-03
Modify Date: 2014-08-24

Data Table ( Complete ):           View All Data
Target
Sequence: RecName: Full=Mu-type opioid receptor; Short=M-OR-1; Short=MOR-1; AltName: Full=Mu opiate receptor; AltName: Full=Mu opioid receptor; Short=MOP; Short=hMOP
Description ..   
Protein Family: Olfactory receptor
Comment ..   

Gene:OPRM1     Related Protein 3D Structures     More BioActivity Data..
Tested Compound:
Description:
Title: Access to 7beta-analogs of codeine with mixed mu/delta agonist activity via 6,7-alpha-epoxide opening.

Abstract: (-)-Codeine 1 was converted into previously unknown 7beta-methyl-7,8-dihydrocodeine/morphine derivatives such as 13 via classical diaxial opening of alpha-epoxide 3. Several analogs exhibited dual mu/delta-agonist activity.
(PMID: 23880538)
Categorized Comment - additional comments and annotations
From BioAssay Depositor:
Assay Type: Binding
Target Type: Target is a single protein chain
Assay Data Source: Scientific Literature
Result Definitions
TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1Ratio EC50 activity commentRatio EC50 activity commentString
2Ratio EC50 standard flagRatio EC50 standard flagInteger
3Ratio EC50 qualifierRatio EC50 qualifierString
4Ratio EC50 published valueRatio EC50 published valueFloat
5Ratio EC50 standard valueRatio EC50 standard valueFloat

Data Table (Concise)
Data Table ( Complete ):     View All Data
Classification
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