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BioAssay: AID 743221

qHTS assay to identify small molecule antagonists of the farnesoid-X-receptor (FXR) signaling pathway - cell viability counter screen

The farnesoid-X-receptor (FXR), a nuclear hormone receptor, is highly expressed in liver, intestine, kidney and adrenal cortex. Natural ligands of FXR are the bile acids (Cholic acid, Chenodeoxy cholic acid etc). FXR is an important regulator of diverse metabolic pathways, including the bile acid homeostasis, lipid and glucose metabolisms. FXR regulates the expression of target genes by binding more ..
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 Tested Compounds
 Tested Compounds
All(7343)
 
 
Active(610)
 
 
Inactive(5577)
 
 
Inconclusive(1727)
 
 
 Tested Substances
 Tested Substances
All(9315)
 
 
Active(691)
 
 
Inactive(6792)
 
 
Inconclusive(1832)
 
 
 Related BioAssays
 Related BioAssays
AID: 743221
Data Source: Tox21 (FXRV189)
BioAssay Type: Confirmatory, Concentration-Response Relationship Observed
Depositor Category: Other
Deposit Date: 2013-12-16
Hold-until Date: 2013-12-31
Modify Date: 2014-01-06

Data Table ( Complete ):           Active    All
BioActive Compounds: 610
Depositor Specified Assays
AIDNameTypeComment
743240qHTS assay to identify small molecule antagonists of the farnesoid-X-receptor (FXR) signaling pathway: Summarysummary
Description:
U.S. Tox21 Program

National Center for Advancing Translational Sciences [NCATS]
NIH Chemical Genomics Center [NCGC]
U.S. Environmental Protection Agency [EPA]
National Institutes of Environmental Health Sciences [NIEHS]
National Toxicology Program [NTP]
U.S. Food and Drug Administration [FDA]

Tox21 Assay Overview:

The farnesoid-X-receptor (FXR), a nuclear hormone receptor, is highly expressed in liver, intestine, kidney and adrenal cortex. Natural ligands of FXR are the bile acids (Cholic acid, Chenodeoxy cholic acid etc). FXR is an important regulator of diverse metabolic pathways, including the bile acid homeostasis, lipid and glucose metabolisms. FXR regulates the expression of target genes by binding either as a monomer or as a heterodimer with the retinoid X receptor (RXR). Numerous studies have reported that FXR exerts protective function during cholestasis, diabetes, liver regeneration, and cancer. To identify compounds that inhibit FXR signaling, GeneBLAzer FXR-UAS-bla HEK 293T cell line (Invitrogen, Carlsbad, CA) containing a beta-lactamase reporter gene under the control of a UAS response element was used to screen the Tox21 10K compound library. The cytotoxicity of the Tox21 compound library against the FXR-bla cell line was tested in parallel by measuring the cell viability using CellTiter-Glo assay in the same wells.
Protocol
Tox21 Assay Protocol Summary:

FXR-bla cells were dispensed at 5000 cells/5uL/well in 1536-well black wall/clear bottom plates using a Multidrop Combi (Thermo Fisher Scientific, Waltham, MA) dispenser. After the assay plates were incubated at 37 C and 5% CO2 for 5 h, 23 nL of compounds dissolved in DMSO, positive controls or DMSO only was transferred to the assay plate by a Pintool station (Kalypsys, San Diego, CA), followed by addition of 1 uL Chenodeoxycholic acid (50 uM, final concentration in the wells). The assay plates were incubated at 37C for 16 h. After 1 uL of LiveBLAzerTM B/G FRET substrate was added using a Bioraptr Flying Reagent Dispenser (FRD) workstation (Beckman Coulter, Indianapolis, IN), the plates were incubated at room temperature for 2 h, and fluorescence intensity was measured by an Envision plate reader (PerkinElmer, Shelton, CT). For cell viability readout that measures cytotoxicity, 4uL/well of CellTiter-Glo reagent was added into the assay plates using a Bioraptr FRD. After 30 min incubation at room temperature, the luminescence intensity in the plates was measured using a ViewLux plate reader (PerkinElmer).
Comment
Disclaimer:

Although all reasonable efforts have been made to ensure the accuracy and reliability of the data, caution should be exercised when interpreting the results as artifacts are possible from nonspecific effects such as assay signal interference. The curve fitting and activity calls presented here are based on the NCATS analysis methods. Alternative analysis methods and interpretations of the data are available at EPA (http://actor.epa.gov) and NTP (http://tools.niehs.nih.gov/cebs3/ui/).

Compound Ranking:

1. Compounds are first classified as having full titration curves, partial modulation, partial curve (weaker actives), single point activity (at highest concentration only), or inactive. See data field "Curve Description". For this assay, apparent inhibitors are ranked higher than compounds that showed apparent activation.
2. For all inactive compounds, PUBCHEM_ACTIVITY_SCORE is 0. For all active compounds, a score range was given for each curve class type given above. Active compounds have PUBCHEM_ACTIVITY_SCORE between 40 and 100. Inconclusive compounds have PUBCHEM_ACTIVITY_SCORE between 1 and 39. Fit_LogAC50 was used for determining relative score and was scaled to each curve class' score range.
Result Definitions
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TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
ScoreThe BioAssay activity ranking scoreInteger
1Phenotype-Replicate_1Indicates type of activity observed: inhibitor, activator, fluorescent, cytotoxic, inactive, or inconclusive.String
2Potency-Replicate_1*Concentration at which compound exhibits half-maximal efficacy, AC50. Extrapolated AC50s also include the highest efficacy observed and the concentration of compound at which it was observed.FloatμM
3Efficacy-Replicate_1Maximal efficacy of compound, reported as a percentage of control. These values are estimated based on fits of the Hill equation to the dose-response curves.Float%
4Analysis Comment-Replicate_1Annotation/notes on a particular compound's data or its analysis.String
5Activity_Score-Replicate_1Activity score.Integer
6Curve_Description-Replicate_1A description of dose-response curve quality. A complete curve has two observed asymptotes; a partial curve may not have attained its second asymptote at the highest concentration tested. High efficacy curves exhibit efficacy greater than 80% of control. Partial efficacies are statistically significant, but below 80% of control.String
7Fit_LogAC50-Replicate_1The logarithm of the AC50 from a fit of the data to the Hill equation (calculated based on Molar Units).Float
8Fit_HillSlope-Replicate_1The Hill slope from a fit of the data to the Hill equation.Float
9Fit_R2-Replicate_1R^2 fit value of the curve. Closer to 1.0 equates to better Hill equation fit.Float
10Fit_InfiniteActivity-Replicate_1The asymptotic efficacy from a fit of the data to the Hill equation.Float%
11Fit_ZeroActivity-Replicate_1Efficacy at zero concentration of compound from a fit of the data to the Hill equation.Float%
12Fit_CurveClass-Replicate_1Numerical encoding of curve description for the fitted Hill equation.Float
13Excluded_Points-Replicate_1Which dose-response titration points were excluded from analysis based on outlier analysis. Each number represents whether a titration point was (1) or was not (0) excluded, for the titration series going from smallest to highest compound concentrations.String
14Max_Response-Replicate_1Maximum activity observed for compound (usually at highest concentration tested).Float%
15Activity at 0.0000056507 uM-Replicate_1 (5.65069e-06μM**)% Activity at given concentration.Float%
16Activity at 0.0000126354 uM-Replicate_1 (1.26354e-05μM**)% Activity at given concentration.Float%
17Activity at 0.0000282534 uM-Replicate_1 (2.82534e-05μM**)% Activity at given concentration.Float%
18Activity at 0.0000545573 uM-Replicate_1 (5.45573e-05μM**)% Activity at given concentration.Float%
19Activity at 0.0001216490 uM-Replicate_1 (0.000121649μM**)% Activity at given concentration.Float%
20Activity at 0.0002748434 uM-Replicate_1 (0.000274843μM**)% Activity at given concentration.Float%
21Activity at 0.0005839002 uM-Replicate_1 (0.0005839μM**)% Activity at given concentration.Float%
22Activity at 0.00107 uM-Replicate_1 (0.00106551μM**)% Activity at given concentration.Float%
23Activity at 0.00238 uM-Replicate_1 (0.00237922μM**)% Activity at given concentration.Float%
24Activity at 0.00531 uM-Replicate_1 (0.00531238μM**)% Activity at given concentration.Float%
25Activity at 0.012 uM-Replicate_1 (0.0118656μM**)% Activity at given concentration.Float%
26Activity at 0.026 uM-Replicate_1 (0.0264438μM**)% Activity at given concentration.Float%
27Activity at 0.059 uM-Replicate_1 (0.0588928μM**)% Activity at given concentration.Float%
28Activity at 0.132 uM-Replicate_1 (0.131506μM**)% Activity at given concentration.Float%
29Activity at 0.275 uM-Replicate_1 (0.27546μM**)% Activity at given concentration.Float%
30Activity at 0.550 uM-Replicate_1 (0.54984μM**)% Activity at given concentration.Float%
31Activity at 1.224 uM-Replicate_1 (1.22441μM**)% Activity at given concentration.Float%
32Activity at 2.686 uM-Replicate_1 (2.68609μM**)% Activity at given concentration.Float%
33Activity at 5.948 uM-Replicate_1 (5.94817μM**)% Activity at given concentration.Float%
34Activity at 13.22 uM-Replicate_1 (13.2238μM**)% Activity at given concentration.Float%
35Activity at 29.14 uM-Replicate_1 (29.1394μM**)% Activity at given concentration.Float%
36Activity at 62.57 uM-Replicate_1 (62.5708μM**)% Activity at given concentration.Float%
37Activity at 81.11 uM-Replicate_1 (81.1055μM**)% Activity at given concentration.Float%
38Activity at 231.6 uM-Replicate_1 (231.639μM**)% Activity at given concentration.Float%
39Activity at 765.1 uM-Replicate_1 (765.1μM**)% Activity at given concentration.Float%
40Compound QC-Replicate_1NCGC designation for data stage: 'qHTS', 'qHTS Verification', 'Secondary Profiling'String
41Phenotype-Replicate_2Indicates type of activity observed: inhibitor, activator, fluorescent, cytotoxic, inactive, or inconclusive.String
42Potency-Replicate_2Concentration at which compound exhibits half-maximal efficacy, AC50. Extrapolated AC50s also include the highest efficacy observed and the concentration of compound at which it was observed.FloatμM
43Efficacy-Replicate_2Maximal efficacy of compound, reported as a percentage of control. These values are estimated based on fits of the Hill equation to the dose-response curves.Float%
44Analysis Comment-Replicate_2Annotation/notes on a particular compound's data or its analysis.String
45Activity_Score-Replicate_2Activity score.Integer
46Curve_Description-Replicate_2A description of dose-response curve quality. A complete curve has two observed asymptotes; a partial curve may not have attained its second asymptote at the highest concentration tested. High efficacy curves exhibit efficacy greater than 80% of control. Partial efficacies are statistically significant, but below 80% of control.String
47Fit_LogAC50-Replicate_2The logarithm of the AC50 from a fit of the data to the Hill equation (calculated based on Molar Units).Float
48Fit_HillSlope-Replicate_2The Hill slope from a fit of the data to the Hill equation.Float
49Fit_R2-Replicate_2R^2 fit value of the curve. Closer to 1.0 equates to better Hill equation fit.Float
50Fit_InfiniteActivity-Replicate_2The asymptotic efficacy from a fit of the data to the Hill equation.Float%
51Fit_ZeroActivity-Replicate_2Efficacy at zero concentration of compound from a fit of the data to the Hill equation.Float%
52Fit_CurveClass-Replicate_2Numerical encoding of curve description for the fitted Hill equation.Float
53Excluded_Points-Replicate_2Which dose-response titration points were excluded from analysis based on outlier analysis. Each number represents whether a titration point was (1) or was not (0) excluded, for the titration series going from smallest to highest compound concentrations.String
54Max_Response-Replicate_2Maximum activity observed for compound (usually at highest concentration tested).Float%
55Activity at 0.0000056507 uM-Replicate_2 (5.65069e-06μM**)% Activity at given concentration.Float%
56Activity at 0.0000126354 uM-Replicate_2 (1.26354e-05μM**)% Activity at given concentration.Float%
57Activity at 0.0000282534 uM-Replicate_2 (2.82534e-05μM**)% Activity at given concentration.Float%
58Activity at 0.0000545573 uM-Replicate_2 (5.45573e-05μM**)% Activity at given concentration.Float%
59Activity at 0.0001216490 uM-Replicate_2 (0.000121649μM**)% Activity at given concentration.Float%
60Activity at 0.0002748434 uM-Replicate_2 (0.000274843μM**)% Activity at given concentration.Float%
61Activity at 0.0005839002 uM-Replicate_2 (0.0005839μM**)% Activity at given concentration.Float%
62Activity at 0.00107 uM-Replicate_2 (0.00106551μM**)% Activity at given concentration.Float%
63Activity at 0.00238 uM-Replicate_2 (0.00237922μM**)% Activity at given concentration.Float%
64Activity at 0.00531 uM-Replicate_2 (0.00531238μM**)% Activity at given concentration.Float%
65Activity at 0.012 uM-Replicate_2 (0.0118656μM**)% Activity at given concentration.Float%
66Activity at 0.026 uM-Replicate_2 (0.0264438μM**)% Activity at given concentration.Float%
67Activity at 0.059 uM-Replicate_2 (0.0588928μM**)% Activity at given concentration.Float%
68Activity at 0.132 uM-Replicate_2 (0.131506μM**)% Activity at given concentration.Float%
69Activity at 0.275 uM-Replicate_2 (0.27546μM**)% Activity at given concentration.Float%
70Activity at 0.550 uM-Replicate_2 (0.54984μM**)% Activity at given concentration.Float%
71Activity at 1.224 uM-Replicate_2 (1.22441μM**)% Activity at given concentration.Float%
72Activity at 2.686 uM-Replicate_2 (2.68609μM**)% Activity at given concentration.Float%
73Activity at 5.948 uM-Replicate_2 (5.94817μM**)% Activity at given concentration.Float%
74Activity at 13.22 uM-Replicate_2 (13.2238μM**)% Activity at given concentration.Float%
75Activity at 29.14 uM-Replicate_2 (29.1394μM**)% Activity at given concentration.Float%
76Activity at 62.57 uM-Replicate_2 (62.5708μM**)% Activity at given concentration.Float%
77Activity at 81.11 uM-Replicate_2 (81.1055μM**)% Activity at given concentration.Float%
78Activity at 231.6 uM-Replicate_2 (231.639μM**)% Activity at given concentration.Float%
79Activity at 765.1 uM-Replicate_2 (765.1μM**)% Activity at given concentration.Float%
80Phenotype-Replicate_3Indicates type of activity observed: inhibitor, activator, fluorescent, cytotoxic, inactive, or inconclusive.String
81Potency-Replicate_3Concentration at which compound exhibits half-maximal efficacy, AC50. Extrapolated AC50s also include the highest efficacy observed and the concentration of compound at which it was observed.FloatμM
82Efficacy-Replicate_3Maximal efficacy of compound, reported as a percentage of control. These values are estimated based on fits of the Hill equation to the dose-response curves.Float%
83Analysis Comment-Replicate_3Annotation/notes on a particular compound's data or its analysis.String
84Activity_Score-Replicate_3Activity score.Integer
85Curve_Description-Replicate_3A description of dose-response curve quality. A complete curve has two observed asymptotes; a partial curve may not have attained its second asymptote at the highest concentration tested. High efficacy curves exhibit efficacy greater than 80% of control. Partial efficacies are statistically significant, but below 80% of control.String
86Fit_LogAC50-Replicate_3The logarithm of the AC50 from a fit of the data to the Hill equation (calculated based on Molar Units).Float
87Fit_HillSlope-Replicate_3The Hill slope from a fit of the data to the Hill equation.Float
88Fit_R2-Replicate_3R^2 fit value of the curve. Closer to 1.0 equates to better Hill equation fit.Float
89Fit_InfiniteActivity-Replicate_3The asymptotic efficacy from a fit of the data to the Hill equation.Float%
90Fit_ZeroActivity-Replicate_3Efficacy at zero concentration of compound from a fit of the data to the Hill equation.Float%
91Fit_CurveClass-Replicate_3Numerical encoding of curve description for the fitted Hill equation.Float
92Excluded_Points-Replicate_3Which dose-response titration points were excluded from analysis based on outlier analysis. Each number represents whether a titration point was (1) or was not (0) excluded, for the titration series going from smallest to highest compound concentrations.String
93Max_Response-Replicate_3Maximum activity observed for compound (usually at highest concentration tested).Float%
94Activity at 0.0000056507 uM-Replicate_3 (5.65069e-06μM**)% Activity at given concentration.Float%
95Activity at 0.0000126354 uM-Replicate_3 (1.26354e-05μM**)% Activity at given concentration.Float%
96Activity at 0.0000282534 uM-Replicate_3 (2.82534e-05μM**)% Activity at given concentration.Float%
97Activity at 0.0000545573 uM-Replicate_3 (5.45573e-05μM**)% Activity at given concentration.Float%
98Activity at 0.0001216490 uM-Replicate_3 (0.000121649μM**)% Activity at given concentration.Float%
99Activity at 0.0002748434 uM-Replicate_3 (0.000274843μM**)% Activity at given concentration.Float%
100Activity at 0.0005839002 uM-Replicate_3 (0.0005839μM**)% Activity at given concentration.Float%
101Activity at 0.00107 uM-Replicate_3 (0.00106551μM**)% Activity at given concentration.Float%
102Activity at 0.00238 uM-Replicate_3 (0.00237922μM**)% Activity at given concentration.Float%
103Activity at 0.00531 uM-Replicate_3 (0.00531238μM**)% Activity at given concentration.Float%
104Activity at 0.012 uM-Replicate_3 (0.0118656μM**)% Activity at given concentration.Float%
105Activity at 0.026 uM-Replicate_3 (0.0264438μM**)% Activity at given concentration.Float%
106Activity at 0.059 uM-Replicate_3 (0.0588928μM**)% Activity at given concentration.Float%
107Activity at 0.132 uM-Replicate_3 (0.131506μM**)% Activity at given concentration.Float%
108Activity at 0.275 uM-Replicate_3 (0.27546μM**)% Activity at given concentration.Float%
109Activity at 0.550 uM-Replicate_3 (0.54984μM**)% Activity at given concentration.Float%
110Activity at 1.224 uM-Replicate_3 (1.22441μM**)% Activity at given concentration.Float%
111Activity at 2.686 uM-Replicate_3 (2.68609μM**)% Activity at given concentration.Float%
112Activity at 5.948 uM-Replicate_3 (5.94817μM**)% Activity at given concentration.Float%
113Activity at 13.22 uM-Replicate_3 (13.2238μM**)% Activity at given concentration.Float%
114Activity at 29.14 uM-Replicate_3 (29.1394μM**)% Activity at given concentration.Float%
115Activity at 62.57 uM-Replicate_3 (62.5708μM**)% Activity at given concentration.Float%
116Activity at 81.11 uM-Replicate_3 (81.1055μM**)% Activity at given concentration.Float%
117Activity at 231.6 uM-Replicate_3 (231.639μM**)% Activity at given concentration.Float%
118Activity at 765.1 uM-Replicate_3 (765.1μM**)% Activity at given concentration.Float%
119Phenotype-Replicate_4Indicates type of activity observed: inhibitor, activator, fluorescent, cytotoxic, inactive, or inconclusive.String
120Potency-Replicate_4Concentration at which compound exhibits half-maximal efficacy, AC50. Extrapolated AC50s also include the highest efficacy observed and the concentration of compound at which it was observed.FloatμM
121Efficacy-Replicate_4Maximal efficacy of compound, reported as a percentage of control. These values are estimated based on fits of the Hill equation to the dose-response curves.Float%
122Analysis Comment-Replicate_4Annotation/notes on a particular compound's data or its analysis.String
123Activity_Score-Replicate_4Activity score.Integer
124Curve_Description-Replicate_4A description of dose-response curve quality. A complete curve has two observed asymptotes; a partial curve may not have attained its second asymptote at the highest concentration tested. High efficacy curves exhibit efficacy greater than 80% of control. Partial efficacies are statistically significant, but below 80% of control.String
125Fit_LogAC50-Replicate_4The logarithm of the AC50 from a fit of the data to the Hill equation (calculated based on Molar Units).Float
126Fit_HillSlope-Replicate_4The Hill slope from a fit of the data to the Hill equation.Float
127Fit_R2-Replicate_4R^2 fit value of the curve. Closer to 1.0 equates to better Hill equation fit.Float
128Fit_InfiniteActivity-Replicate_4The asymptotic efficacy from a fit of the data to the Hill equation.Float%
129Fit_ZeroActivity-Replicate_4Efficacy at zero concentration of compound from a fit of the data to the Hill equation.Float%
130Fit_CurveClass-Replicate_4Numerical encoding of curve description for the fitted Hill equation.Float
131Excluded_Points-Replicate_4Which dose-response titration points were excluded from analysis based on outlier analysis. Each number represents whether a titration point was (1) or was not (0) excluded, for the titration series going from smallest to highest compound concentrations.String
132Max_Response-Replicate_4Maximum activity observed for compound (usually at highest concentration tested).Float%
133Activity at 0.0000056507 uM-Replicate_4 (5.65069e-06μM**)% Activity at given concentration.Float%
134Activity at 0.0000126354 uM-Replicate_4 (1.26354e-05μM**)% Activity at given concentration.Float%
135Activity at 0.0000282534 uM-Replicate_4 (2.82534e-05μM**)% Activity at given concentration.Float%
136Activity at 0.0000545573 uM-Replicate_4 (5.45573e-05μM**)% Activity at given concentration.Float%
137Activity at 0.0001216490 uM-Replicate_4 (0.000121649μM**)% Activity at given concentration.Float%
138Activity at 0.0002748434 uM-Replicate_4 (0.000274843μM**)% Activity at given concentration.Float%
139Activity at 0.0005839002 uM-Replicate_4 (0.0005839μM**)% Activity at given concentration.Float%
140Activity at 0.00107 uM-Replicate_4 (0.00106551μM**)% Activity at given concentration.Float%
141Activity at 0.00238 uM-Replicate_4 (0.00237922μM**)% Activity at given concentration.Float%
142Activity at 0.00531 uM-Replicate_4 (0.00531238μM**)% Activity at given concentration.Float%
143Activity at 0.012 uM-Replicate_4 (0.0118656μM**)% Activity at given concentration.Float%
144Activity at 0.026 uM-Replicate_4 (0.0264438μM**)% Activity at given concentration.Float%
145Activity at 0.059 uM-Replicate_4 (0.0588928μM**)% Activity at given concentration.Float%
146Activity at 0.132 uM-Replicate_4 (0.131506μM**)% Activity at given concentration.Float%
147Activity at 0.275 uM-Replicate_4 (0.27546μM**)% Activity at given concentration.Float%
148Activity at 0.550 uM-Replicate_4 (0.54984μM**)% Activity at given concentration.Float%
149Activity at 1.224 uM-Replicate_4 (1.22441μM**)% Activity at given concentration.Float%
150Activity at 2.686 uM-Replicate_4 (2.68609μM**)% Activity at given concentration.Float%
151Activity at 5.948 uM-Replicate_4 (5.94817μM**)% Activity at given concentration.Float%
152Activity at 13.22 uM-Replicate_4 (13.2238μM**)% Activity at given concentration.Float%
153Activity at 29.14 uM-Replicate_4 (29.1394μM**)% Activity at given concentration.Float%
154Activity at 62.57 uM-Replicate_4 (62.5708μM**)% Activity at given concentration.Float%
155Activity at 81.11 uM-Replicate_4 (81.1055μM**)% Activity at given concentration.Float%
156Activity at 231.6 uM-Replicate_4 (231.639μM**)% Activity at given concentration.Float%
157Activity at 765.1 uM-Replicate_4 (765.1μM**)% Activity at given concentration.Float%
158Phenotype-Replicate_5Indicates type of activity observed: inhibitor, activator, fluorescent, cytotoxic, inactive, or inconclusive.String
159Potency-Replicate_5Concentration at which compound exhibits half-maximal efficacy, AC50. Extrapolated AC50s also include the highest efficacy observed and the concentration of compound at which it was observed.FloatμM
160Efficacy-Replicate_5Maximal efficacy of compound, reported as a percentage of control. These values are estimated based on fits of the Hill equation to the dose-response curves.Float%
161Analysis Comment-Replicate_5Annotation/notes on a particular compound's data or its analysis.String
162Activity_Score-Replicate_5Activity score.Integer
163Curve_Description-Replicate_5A description of dose-response curve quality. A complete curve has two observed asymptotes; a partial curve may not have attained its second asymptote at the highest concentration tested. High efficacy curves exhibit efficacy greater than 80% of control. Partial efficacies are statistically significant, but below 80% of control.String
164Fit_LogAC50-Replicate_5The logarithm of the AC50 from a fit of the data to the Hill equation (calculated based on Molar Units).Float
165Fit_HillSlope-Replicate_5The Hill slope from a fit of the data to the Hill equation.Float
166Fit_R2-Replicate_5R^2 fit value of the curve. Closer to 1.0 equates to better Hill equation fit.Float
167Fit_InfiniteActivity-Replicate_5The asymptotic efficacy from a fit of the data to the Hill equation.Float%
168Fit_ZeroActivity-Replicate_5Efficacy at zero concentration of compound from a fit of the data to the Hill equation.Float%
169Fit_CurveClass-Replicate_5Numerical encoding of curve description for the fitted Hill equation.Float
170Excluded_Points-Replicate_5Which dose-response titration points were excluded from analysis based on outlier analysis. Each number represents whether a titration point was (1) or was not (0) excluded, for the titration series going from smallest to highest compound concentrations.String
171Max_Response-Replicate_5Maximum activity observed for compound (usually at highest concentration tested).Float%
172Activity at 0.0000056507 uM-Replicate_5 (5.65069e-06μM**)% Activity at given concentration.Float%
173Activity at 0.0000126354 uM-Replicate_5 (1.26354e-05μM**)% Activity at given concentration.Float%
174Activity at 0.0000282534 uM-Replicate_5 (2.82534e-05μM**)% Activity at given concentration.Float%
175Activity at 0.0000545573 uM-Replicate_5 (5.45573e-05μM**)% Activity at given concentration.Float%
176Activity at 0.0001216490 uM-Replicate_5 (0.000121649μM**)% Activity at given concentration.Float%
177Activity at 0.0002748434 uM-Replicate_5 (0.000274843μM**)% Activity at given concentration.Float%
178Activity at 0.0005839002 uM-Replicate_5 (0.0005839μM**)% Activity at given concentration.Float%
179Activity at 0.00107 uM-Replicate_5 (0.00106551μM**)% Activity at given concentration.Float%
180Activity at 0.00238 uM-Replicate_5 (0.00237922μM**)% Activity at given concentration.Float%
181Activity at 0.00531 uM-Replicate_5 (0.00531238μM**)% Activity at given concentration.Float%
182Activity at 0.012 uM-Replicate_5 (0.0118656μM**)% Activity at given concentration.Float%
183Activity at 0.026 uM-Replicate_5 (0.0264438μM**)% Activity at given concentration.Float%
184Activity at 0.059 uM-Replicate_5 (0.0588928μM**)% Activity at given concentration.Float%
185Activity at 0.132 uM-Replicate_5 (0.131506μM**)% Activity at given concentration.Float%
186Activity at 0.275 uM-Replicate_5 (0.27546μM**)% Activity at given concentration.Float%
187Activity at 0.550 uM-Replicate_5 (0.54984μM**)% Activity at given concentration.Float%
188Activity at 1.224 uM-Replicate_5 (1.22441μM**)% Activity at given concentration.Float%
189Activity at 2.686 uM-Replicate_5 (2.68609μM**)% Activity at given concentration.Float%
190Activity at 5.948 uM-Replicate_5 (5.94817μM**)% Activity at given concentration.Float%
191Activity at 13.22 uM-Replicate_5 (13.2238μM**)% Activity at given concentration.Float%
192Activity at 29.14 uM-Replicate_5 (29.1394μM**)% Activity at given concentration.Float%
193Activity at 62.57 uM-Replicate_5 (62.5708μM**)% Activity at given concentration.Float%
194Activity at 81.11 uM-Replicate_5 (81.1055μM**)% Activity at given concentration.Float%
195Activity at 231.6 uM-Replicate_5 (231.639μM**)% Activity at given concentration.Float%
196Activity at 765.1 uM-Replicate_5 (765.1μM**)% Activity at given concentration.Float%
197Phenotype-Replicate_6Indicates type of activity observed: inhibitor, activator, fluorescent, cytotoxic, inactive, or inconclusive.String
198Potency-Replicate_6Concentration at which compound exhibits half-maximal efficacy, AC50. Extrapolated AC50s also include the highest efficacy observed and the concentration of compound at which it was observed.FloatμM
199Efficacy-Replicate_6Maximal efficacy of compound, reported as a percentage of control. These values are estimated based on fits of the Hill equation to the dose-response curves.Float%
200Analysis Comment-Replicate_6Annotation/notes on a particular compound's data or its analysis.String
201Activity_Score-Replicate_6Activity score.Integer
202Curve_Description-Replicate_6A description of dose-response curve quality. A complete curve has two observed asymptotes; a partial curve may not have attained its second asymptote at the highest concentration tested. High efficacy curves exhibit efficacy greater than 80% of control. Partial efficacies are statistically significant, but below 80% of control.String
203Fit_LogAC50-Replicate_6The logarithm of the AC50 from a fit of the data to the Hill equation (calculated based on Molar Units).Float
204Fit_HillSlope-Replicate_6The Hill slope from a fit of the data to the Hill equation.Float
205Fit_R2-Replicate_6R^2 fit value of the curve. Closer to 1.0 equates to better Hill equation fit.Float
206Fit_InfiniteActivity-Replicate_6The asymptotic efficacy from a fit of the data to the Hill equation.Float%
207Fit_ZeroActivity-Replicate_6Efficacy at zero concentration of compound from a fit of the data to the Hill equation.Float%
208Fit_CurveClass-Replicate_6Numerical encoding of curve description for the fitted Hill equation.Float
209Excluded_Points-Replicate_6Which dose-response titration points were excluded from analysis based on outlier analysis. Each number represents whether a titration point was (1) or was not (0) excluded, for the titration series going from smallest to highest compound concentrations.String
210Max_Response-Replicate_6Maximum activity observed for compound (usually at highest concentration tested).Float%
211Activity at 0.0000056507 uM-Replicate_6 (5.65069e-06μM**)% Activity at given concentration.Float%
212Activity at 0.0000126354 uM-Replicate_6 (1.26354e-05μM**)% Activity at given concentration.Float%
213Activity at 0.0000282534 uM-Replicate_6 (2.82534e-05μM**)% Activity at given concentration.Float%
214Activity at 0.0000545573 uM-Replicate_6 (5.45573e-05μM**)% Activity at given concentration.Float%
215Activity at 0.0001216490 uM-Replicate_6 (0.000121649μM**)% Activity at given concentration.Float%
216Activity at 0.0002748434 uM-Replicate_6 (0.000274843μM**)% Activity at given concentration.Float%
217Activity at 0.0005839002 uM-Replicate_6 (0.0005839μM**)% Activity at given concentration.Float%
218Activity at 0.00107 uM-Replicate_6 (0.00106551μM**)% Activity at given concentration.Float%
219Activity at 0.00238 uM-Replicate_6 (0.00237922μM**)% Activity at given concentration.Float%
220Activity at 0.00531 uM-Replicate_6 (0.00531238μM**)% Activity at given concentration.Float%
221Activity at 0.012 uM-Replicate_6 (0.0118656μM**)% Activity at given concentration.Float%
222Activity at 0.026 uM-Replicate_6 (0.0264438μM**)% Activity at given concentration.Float%
223Activity at 0.059 uM-Replicate_6 (0.0588928μM**)% Activity at given concentration.Float%
224Activity at 0.132 uM-Replicate_6 (0.131506μM**)% Activity at given concentration.Float%
225Activity at 0.275 uM-Replicate_6 (0.27546μM**)% Activity at given concentration.Float%
226Activity at 0.550 uM-Replicate_6 (0.54984μM**)% Activity at given concentration.Float%
227Activity at 1.224 uM-Replicate_6 (1.22441μM**)% Activity at given concentration.Float%
228Activity at 2.686 uM-Replicate_6 (2.68609μM**)% Activity at given concentration.Float%
229Activity at 5.948 uM-Replicate_6 (5.94817μM**)% Activity at given concentration.Float%
230Activity at 13.22 uM-Replicate_6 (13.2238μM**)% Activity at given concentration.Float%
231Activity at 29.14 uM-Replicate_6 (29.1394μM**)% Activity at given concentration.Float%
232Activity at 62.57 uM-Replicate_6 (62.5708μM**)% Activity at given concentration.Float%
233Activity at 81.11 uM-Replicate_6 (81.1055μM**)% Activity at given concentration.Float%
234Activity at 231.6 uM-Replicate_6 (231.639μM**)% Activity at given concentration.Float%
235Activity at 765.1 uM-Replicate_6 (765.1μM**)% Activity at given concentration.Float%
236Phenotype-Replicate_7Indicates type of activity observed: inhibitor, activator, fluorescent, cytotoxic, inactive, or inconclusive.String
237Potency-Replicate_7Concentration at which compound exhibits half-maximal efficacy, AC50. Extrapolated AC50s also include the highest efficacy observed and the concentration of compound at which it was observed.FloatμM
238Efficacy-Replicate_7Maximal efficacy of compound, reported as a percentage of control. These values are estimated based on fits of the Hill equation to the dose-response curves.Float%
239Analysis Comment-Replicate_7Annotation/notes on a particular compound's data or its analysis.String
240Activity_Score-Replicate_7Activity score.Integer
241Curve_Description-Replicate_7A description of dose-response curve quality. A complete curve has two observed asymptotes; a partial curve may not have attained its second asymptote at the highest concentration tested. High efficacy curves exhibit efficacy greater than 80% of control. Partial efficacies are statistically significant, but below 80% of control.String
242Fit_LogAC50-Replicate_7The logarithm of the AC50 from a fit of the data to the Hill equation (calculated based on Molar Units).Float
243Fit_HillSlope-Replicate_7The Hill slope from a fit of the data to the Hill equation.Float
244Fit_R2-Replicate_7R^2 fit value of the curve. Closer to 1.0 equates to better Hill equation fit.Float
245Fit_InfiniteActivity-Replicate_7The asymptotic efficacy from a fit of the data to the Hill equation.Float%
246Fit_ZeroActivity-Replicate_7Efficacy at zero concentration of compound from a fit of the data to the Hill equation.Float%
247Fit_CurveClass-Replicate_7Numerical encoding of curve description for the fitted Hill equation.Float
248Excluded_Points-Replicate_7Which dose-response titration points were excluded from analysis based on outlier analysis. Each number represents whether a titration point was (1) or was not (0) excluded, for the titration series going from smallest to highest compound concentrations.String
249Max_Response-Replicate_7Maximum activity observed for compound (usually at highest concentration tested).Float%
250Activity at 0.0000056507 uM-Replicate_7 (5.65069e-06μM**)% Activity at given concentration.Float%
251Activity at 0.0000126354 uM-Replicate_7 (1.26354e-05μM**)% Activity at given concentration.Float%
252Activity at 0.0000282534 uM-Replicate_7 (2.82534e-05μM**)% Activity at given concentration.Float%
253Activity at 0.0000545573 uM-Replicate_7 (5.45573e-05μM**)% Activity at given concentration.Float%
254Activity at 0.0001216490 uM-Replicate_7 (0.000121649μM**)% Activity at given concentration.Float%
255Activity at 0.0002748434 uM-Replicate_7 (0.000274843μM**)% Activity at given concentration.Float%
256Activity at 0.0005839002 uM-Replicate_7 (0.0005839μM**)% Activity at given concentration.Float%
257Activity at 0.00107 uM-Replicate_7 (0.00106551μM**)% Activity at given concentration.Float%
258Activity at 0.00238 uM-Replicate_7 (0.00237922μM**)% Activity at given concentration.Float%
259Activity at 0.00531 uM-Replicate_7 (0.00531238μM**)% Activity at given concentration.Float%
260Activity at 0.012 uM-Replicate_7 (0.0118656μM**)% Activity at given concentration.Float%
261Activity at 0.026 uM-Replicate_7 (0.0264438μM**)% Activity at given concentration.Float%
262Activity at 0.059 uM-Replicate_7 (0.0588928μM**)% Activity at given concentration.Float%
263Activity at 0.132 uM-Replicate_7 (0.131506μM**)% Activity at given concentration.Float%
264Activity at 0.275 uM-Replicate_7 (0.27546μM**)% Activity at given concentration.Float%
265Activity at 0.550 uM-Replicate_7 (0.54984μM**)% Activity at given concentration.Float%
266Activity at 1.224 uM-Replicate_7 (1.22441μM**)% Activity at given concentration.Float%
267Activity at 2.686 uM-Replicate_7 (2.68609μM**)% Activity at given concentration.Float%
268Activity at 5.948 uM-Replicate_7 (5.94817μM**)% Activity at given concentration.Float%
269Activity at 13.22 uM-Replicate_7 (13.2238μM**)% Activity at given concentration.Float%
270Activity at 29.14 uM-Replicate_7 (29.1394μM**)% Activity at given concentration.Float%
271Activity at 62.57 uM-Replicate_7 (62.5708μM**)% Activity at given concentration.Float%
272Activity at 81.11 uM-Replicate_7 (81.1055μM**)% Activity at given concentration.Float%
273Activity at 231.6 uM-Replicate_7 (231.639μM**)% Activity at given concentration.Float%
274Activity at 765.1 uM-Replicate_7 (765.1μM**)% Activity at given concentration.Float%
275Phenotype-Replicate_8Indicates type of activity observed: inhibitor, activator, fluorescent, cytotoxic, inactive, or inconclusive.String
276Potency-Replicate_8Concentration at which compound exhibits half-maximal efficacy, AC50. Extrapolated AC50s also include the highest efficacy observed and the concentration of compound at which it was observed.FloatμM
277Efficacy-Replicate_8Maximal efficacy of compound, reported as a percentage of control. These values are estimated based on fits of the Hill equation to the dose-response curves.Float%
278Analysis Comment-Replicate_8Annotation/notes on a particular compound's data or its analysis.String
279Activity_Score-Replicate_8Activity score.Integer
280Curve_Description-Replicate_8A description of dose-response curve quality. A complete curve has two observed asymptotes; a partial curve may not have attained its second asymptote at the highest concentration tested. High efficacy curves exhibit efficacy greater than 80% of control. Partial efficacies are statistically significant, but below 80% of control.String
281Fit_LogAC50-Replicate_8The logarithm of the AC50 from a fit of the data to the Hill equation (calculated based on Molar Units).Float
282Fit_HillSlope-Replicate_8The Hill slope from a fit of the data to the Hill equation.Float
283Fit_R2-Replicate_8R^2 fit value of the curve. Closer to 1.0 equates to better Hill equation fit.Float
284Fit_InfiniteActivity-Replicate_8The asymptotic efficacy from a fit of the data to the Hill equation.Float%
285Fit_ZeroActivity-Replicate_8Efficacy at zero concentration of compound from a fit of the data to the Hill equation.Float%
286Fit_CurveClass-Replicate_8Numerical encoding of curve description for the fitted Hill equation.Float
287Excluded_Points-Replicate_8Which dose-response titration points were excluded from analysis based on outlier analysis. Each number represents whether a titration point was (1) or was not (0) excluded, for the titration series going from smallest to highest compound concentrations.String
288Max_Response-Replicate_8Maximum activity observed for compound (usually at highest concentration tested).Float%
289Activity at 0.0000056507 uM-Replicate_8 (5.65069e-06μM**)% Activity at given concentration.Float%
290Activity at 0.0000126354 uM-Replicate_8 (1.26354e-05μM**)% Activity at given concentration.Float%
291Activity at 0.0000282534 uM-Replicate_8 (2.82534e-05μM**)% Activity at given concentration.Float%
292Activity at 0.0000545573 uM-Replicate_8 (5.45573e-05μM**)% Activity at given concentration.Float%
293Activity at 0.0001216490 uM-Replicate_8 (0.000121649μM**)% Activity at given concentration.Float%
294Activity at 0.0002748434 uM-Replicate_8 (0.000274843μM**)% Activity at given concentration.Float%
295Activity at 0.0005839002 uM-Replicate_8 (0.0005839μM**)% Activity at given concentration.Float%
296Activity at 0.00107 uM-Replicate_8 (0.00106551μM**)% Activity at given concentration.Float%
297Activity at 0.00238 uM-Replicate_8 (0.00237922μM**)% Activity at given concentration.Float%
298Activity at 0.00531 uM-Replicate_8 (0.00531238μM**)% Activity at given concentration.Float%
299Activity at 0.012 uM-Replicate_8 (0.0118656μM**)% Activity at given concentration.Float%
300Activity at 0.026 uM-Replicate_8 (0.0264438μM**)% Activity at given concentration.Float%
301Activity at 0.059 uM-Replicate_8 (0.0588928μM**)% Activity at given concentration.Float%
302Activity at 0.132 uM-Replicate_8 (0.131506μM**)% Activity at given concentration.Float%
303Activity at 0.275 uM-Replicate_8 (0.27546μM**)% Activity at given concentration.Float%
304Activity at 0.550 uM-Replicate_8 (0.54984μM**)% Activity at given concentration.Float%
305Activity at 1.224 uM-Replicate_8 (1.22441μM**)% Activity at given concentration.Float%
306Activity at 2.686 uM-Replicate_8 (2.68609μM**)% Activity at given concentration.Float%
307Activity at 5.948 uM-Replicate_8 (5.94817μM**)% Activity at given concentration.Float%
308Activity at 13.22 uM-Replicate_8 (13.2238μM**)% Activity at given concentration.Float%
309Activity at 29.14 uM-Replicate_8 (29.1394μM**)% Activity at given concentration.Float%
310Activity at 62.57 uM-Replicate_8 (62.5708μM**)% Activity at given concentration.Float%
311Activity at 81.11 uM-Replicate_8 (81.1055μM**)% Activity at given concentration.Float%
312Activity at 231.6 uM-Replicate_8 (231.639μM**)% Activity at given concentration.Float%
313Activity at 765.1 uM-Replicate_8 (765.1μM**)% Activity at given concentration.Float%
314Phenotype-Replicate_9Indicates type of activity observed: inhibitor, activator, fluorescent, cytotoxic, inactive, or inconclusive.String
315Potency-Replicate_9Concentration at which compound exhibits half-maximal efficacy, AC50. Extrapolated AC50s also include the highest efficacy observed and the concentration of compound at which it was observed.FloatμM
316Efficacy-Replicate_9Maximal efficacy of compound, reported as a percentage of control. These values are estimated based on fits of the Hill equation to the dose-response curves.Float%
317Analysis Comment-Replicate_9Annotation/notes on a particular compound's data or its analysis.String
318Activity_Score-Replicate_9Activity score.Integer
319Curve_Description-Replicate_9A description of dose-response curve quality. A complete curve has two observed asymptotes; a partial curve may not have attained its second asymptote at the highest concentration tested. High efficacy curves exhibit efficacy greater than 80% of control. Partial efficacies are statistically significant, but below 80% of control.String
320Fit_LogAC50-Replicate_9The logarithm of the AC50 from a fit of the data to the Hill equation (calculated based on Molar Units).Float
321Fit_HillSlope-Replicate_9The Hill slope from a fit of the data to the Hill equation.Float
322Fit_R2-Replicate_9R^2 fit value of the curve. Closer to 1.0 equates to better Hill equation fit.Float
323Fit_InfiniteActivity-Replicate_9The asymptotic efficacy from a fit of the data to the Hill equation.Float%
324Fit_ZeroActivity-Replicate_9Efficacy at zero concentration of compound from a fit of the data to the Hill equation.Float%
325Fit_CurveClass-Replicate_9Numerical encoding of curve description for the fitted Hill equation.Float
326Excluded_Points-Replicate_9Which dose-response titration points were excluded from analysis based on outlier analysis. Each number represents whether a titration point was (1) or was not (0) excluded, for the titration series going from smallest to highest compound concentrations.String
327Max_Response-Replicate_9Maximum activity observed for compound (usually at highest concentration tested).Float%
328Activity at 0.0000056507 uM-Replicate_9 (5.65069e-06μM**)% Activity at given concentration.Float%
329Activity at 0.0000126354 uM-Replicate_9 (1.26354e-05μM**)% Activity at given concentration.Float%
330Activity at 0.0000282534 uM-Replicate_9 (2.82534e-05μM**)% Activity at given concentration.Float%
331Activity at 0.0000545573 uM-Replicate_9 (5.45573e-05μM**)% Activity at given concentration.Float%
332Activity at 0.0001216490 uM-Replicate_9 (0.000121649μM**)% Activity at given concentration.Float%
333Activity at 0.0002748434 uM-Replicate_9 (0.000274843μM**)% Activity at given concentration.Float%
334Activity at 0.0005839002 uM-Replicate_9 (0.0005839μM**)% Activity at given concentration.Float%
335Activity at 0.00107 uM-Replicate_9 (0.00106551μM**)% Activity at given concentration.Float%
336Activity at 0.00238 uM-Replicate_9 (0.00237922μM**)% Activity at given concentration.Float%
337Activity at 0.00531 uM-Replicate_9 (0.00531238μM**)% Activity at given concentration.Float%
338Activity at 0.012 uM-Replicate_9 (0.0118656μM**)% Activity at given concentration.Float%
339Activity at 0.026 uM-Replicate_9 (0.0264438μM**)% Activity at given concentration.Float%
340Activity at 0.059 uM-Replicate_9 (0.0588928μM**)% Activity at given concentration.Float%
341Activity at 0.132 uM-Replicate_9 (0.131506μM**)% Activity at given concentration.Float%
342Activity at 0.275 uM-Replicate_9 (0.27546μM**)% Activity at given concentration.Float%
343Activity at 0.550 uM-Replicate_9 (0.54984μM**)% Activity at given concentration.Float%
344Activity at 1.224 uM-Replicate_9 (1.22441μM**)% Activity at given concentration.Float%
345Activity at 2.686 uM-Replicate_9 (2.68609μM**)% Activity at given concentration.Float%
346Activity at 5.948 uM-Replicate_9 (5.94817μM**)% Activity at given concentration.Float%
347Activity at 13.22 uM-Replicate_9 (13.2238μM**)% Activity at given concentration.Float%
348Activity at 29.14 uM-Replicate_9 (29.1394μM**)% Activity at given concentration.Float%
349Activity at 62.57 uM-Replicate_9 (62.5708μM**)% Activity at given concentration.Float%
350Activity at 81.11 uM-Replicate_9 (81.1055μM**)% Activity at given concentration.Float%
351Activity at 231.6 uM-Replicate_9 (231.639μM**)% Activity at given concentration.Float%
352Activity at 765.1 uM-Replicate_9 (765.1μM**)% Activity at given concentration.Float%
353Phenotype-Replicate_10Indicates type of activity observed: inhibitor, activator, fluorescent, cytotoxic, inactive, or inconclusive.String
354Potency-Replicate_10Concentration at which compound exhibits half-maximal efficacy, AC50. Extrapolated AC50s also include the highest efficacy observed and the concentration of compound at which it was observed.FloatμM
355Efficacy-Replicate_10Maximal efficacy of compound, reported as a percentage of control. These values are estimated based on fits of the Hill equation to the dose-response curves.Float%
356Analysis Comment-Replicate_10Annotation/notes on a particular compound's data or its analysis.String
357Activity_Score-Replicate_10Activity score.Integer
358Curve_Description-Replicate_10A description of dose-response curve quality. A complete curve has two observed asymptotes; a partial curve may not have attained its second asymptote at the highest concentration tested. High efficacy curves exhibit efficacy greater than 80% of control. Partial efficacies are statistically significant, but below 80% of control.String
359Fit_LogAC50-Replicate_10The logarithm of the AC50 from a fit of the data to the Hill equation (calculated based on Molar Units).Float
360Fit_HillSlope-Replicate_10The Hill slope from a fit of the data to the Hill equation.Float
361Fit_R2-Replicate_10R^2 fit value of the curve. Closer to 1.0 equates to better Hill equation fit.Float
362Fit_InfiniteActivity-Replicate_10The asymptotic efficacy from a fit of the data to the Hill equation.Float%
363Fit_ZeroActivity-Replicate_10Efficacy at zero concentration of compound from a fit of the data to the Hill equation.Float%
364Fit_CurveClass-Replicate_10Numerical encoding of curve description for the fitted Hill equation.Float
365Excluded_Points-Replicate_10Which dose-response titration points were excluded from analysis based on outlier analysis. Each number represents whether a titration point was (1) or was not (0) excluded, for the titration series going from smallest to highest compound concentrations.String
366Max_Response-Replicate_10Maximum activity observed for compound (usually at highest concentration tested).Float%
367Activity at 0.0000056507 uM-Replicate_10 (5.65069e-06μM**)% Activity at given concentration.Float%
368Activity at 0.0000126354 uM-Replicate_10 (1.26354e-05μM**)% Activity at given concentration.Float%
369Activity at 0.0000282534 uM-Replicate_10 (2.82534e-05μM**)% Activity at given concentration.Float%
370Activity at 0.0000545573 uM-Replicate_10 (5.45573e-05μM**)% Activity at given concentration.Float%
371Activity at 0.0001216490 uM-Replicate_10 (0.000121649μM**)% Activity at given concentration.Float%
372Activity at 0.0002748434 uM-Replicate_10 (0.000274843μM**)% Activity at given concentration.Float%
373Activity at 0.0005839002 uM-Replicate_10 (0.0005839μM**)% Activity at given concentration.Float%
374Activity at 0.00107 uM-Replicate_10 (0.00106551μM**)% Activity at given concentration.Float%
375Activity at 0.00238 uM-Replicate_10 (0.00237922μM**)% Activity at given concentration.Float%
376Activity at 0.00531 uM-Replicate_10 (0.00531238μM**)% Activity at given concentration.Float%
377Activity at 0.012 uM-Replicate_10 (0.0118656μM**)% Activity at given concentration.Float%
378Activity at 0.026 uM-Replicate_10 (0.0264438μM**)% Activity at given concentration.Float%
379Activity at 0.059 uM-Replicate_10 (0.0588928μM**)% Activity at given concentration.Float%
380Activity at 0.132 uM-Replicate_10 (0.131506μM**)% Activity at given concentration.Float%
381Activity at 0.275 uM-Replicate_10 (0.27546μM**)% Activity at given concentration.Float%
382Activity at 0.550 uM-Replicate_10 (0.54984μM**)% Activity at given concentration.Float%
383Activity at 1.224 uM-Replicate_10 (1.22441μM**)% Activity at given concentration.Float%
384Activity at 2.686 uM-Replicate_10 (2.68609μM**)% Activity at given concentration.Float%
385Activity at 5.948 uM-Replicate_10 (5.94817μM**)% Activity at given concentration.Float%
386Activity at 13.22 uM-Replicate_10 (13.2238μM**)% Activity at given concentration.Float%
387Activity at 29.14 uM-Replicate_10 (29.1394μM**)% Activity at given concentration.Float%
388Activity at 62.57 uM-Replicate_10 (62.5708μM**)% Activity at given concentration.Float%
389Activity at 81.11 uM-Replicate_10 (81.1055μM**)% Activity at given concentration.Float%
390Activity at 231.6 uM-Replicate_10 (231.639μM**)% Activity at given concentration.Float%
391Activity at 765.1 uM-Replicate_10 (765.1μM**)% Activity at given concentration.Float%
392Phenotype-Replicate_11Indicates type of activity observed: inhibitor, activator, fluorescent, cytotoxic, inactive, or inconclusive.String
393Potency-Replicate_11Concentration at which compound exhibits half-maximal efficacy, AC50. Extrapolated AC50s also include the highest efficacy observed and the concentration of compound at which it was observed.FloatμM
394Efficacy-Replicate_11Maximal efficacy of compound, reported as a percentage of control. These values are estimated based on fits of the Hill equation to the dose-response curves.Float%
395Analysis Comment-Replicate_11Annotation/notes on a particular compound's data or its analysis.String
396Activity_Score-Replicate_11Activity score.Integer
397Curve_Description-Replicate_11A description of dose-response curve quality. A complete curve has two observed asymptotes; a partial curve may not have attained its second asymptote at the highest concentration tested. High efficacy curves exhibit efficacy greater than 80% of control. Partial efficacies are statistically significant, but below 80% of control.String
398Fit_LogAC50-Replicate_11The logarithm of the AC50 from a fit of the data to the Hill equation (calculated based on Molar Units).Float
399Fit_HillSlope-Replicate_11The Hill slope from a fit of the data to the Hill equation.Float
400Fit_R2-Replicate_11R^2 fit value of the curve. Closer to 1.0 equates to better Hill equation fit.Float
401Fit_InfiniteActivity-Replicate_11The asymptotic efficacy from a fit of the data to the Hill equation.Float%
402Fit_ZeroActivity-Replicate_11Efficacy at zero concentration of compound from a fit of the data to the Hill equation.Float%
403Fit_CurveClass-Replicate_11Numerical encoding of curve description for the fitted Hill equation.Float
404Excluded_Points-Replicate_11Which dose-response titration points were excluded from analysis based on outlier analysis. Each number represents whether a titration point was (1) or was not (0) excluded, for the titration series going from smallest to highest compound concentrations.String
405Max_Response-Replicate_11Maximum activity observed for compound (usually at highest concentration tested).Float%
406Activity at 0.0000056507 uM-Replicate_11 (5.65069e-06μM**)% Activity at given concentration.Float%
407Activity at 0.0000126354 uM-Replicate_11 (1.26354e-05μM**)% Activity at given concentration.Float%
408Activity at 0.0000282534 uM-Replicate_11 (2.82534e-05μM**)% Activity at given concentration.Float%
409Activity at 0.0000545573 uM-Replicate_11 (5.45573e-05μM**)% Activity at given concentration.Float%
410Activity at 0.0001216490 uM-Replicate_11 (0.000121649μM**)% Activity at given concentration.Float%
411Activity at 0.0002748434 uM-Replicate_11 (0.000274843μM**)% Activity at given concentration.Float%
412Activity at 0.0005839002 uM-Replicate_11 (0.0005839μM**)% Activity at given concentration.Float%
413Activity at 0.00107 uM-Replicate_11 (0.00106551μM**)% Activity at given concentration.Float%
414Activity at 0.00238 uM-Replicate_11 (0.00237922μM**)% Activity at given concentration.Float%
415Activity at 0.00531 uM-Replicate_11 (0.00531238μM**)% Activity at given concentration.Float%
416Activity at 0.012 uM-Replicate_11 (0.0118656μM**)% Activity at given concentration.Float%
417Activity at 0.026 uM-Replicate_11 (0.0264438μM**)% Activity at given concentration.Float%
418Activity at 0.059 uM-Replicate_11 (0.0588928μM**)% Activity at given concentration.Float%
419Activity at 0.132 uM-Replicate_11 (0.131506μM**)% Activity at given concentration.Float%
420Activity at 0.275 uM-Replicate_11 (0.27546μM**)% Activity at given concentration.Float%
421Activity at 0.550 uM-Replicate_11 (0.54984μM**)% Activity at given concentration.Float%
422Activity at 1.224 uM-Replicate_11 (1.22441μM**)% Activity at given concentration.Float%
423Activity at 2.686 uM-Replicate_11 (2.68609μM**)% Activity at given concentration.Float%
424Activity at 5.948 uM-Replicate_11 (5.94817μM**)% Activity at given concentration.Float%
425Activity at 13.22 uM-Replicate_11 (13.2238μM**)% Activity at given concentration.Float%
426Activity at 29.14 uM-Replicate_11 (29.1394μM**)% Activity at given concentration.Float%
427Activity at 62.57 uM-Replicate_11 (62.5708μM**)% Activity at given concentration.Float%
428Activity at 81.11 uM-Replicate_11 (81.1055μM**)% Activity at given concentration.Float%
429Activity at 231.6 uM-Replicate_11 (231.639μM**)% Activity at given concentration.Float%
430Activity at 765.1 uM-Replicate_11 (765.1μM**)% Activity at given concentration.Float%
431Phenotype-Replicate_12Indicates type of activity observed: inhibitor, activator, fluorescent, cytotoxic, inactive, or inconclusive.String
432Potency-Replicate_12Concentration at which compound exhibits half-maximal efficacy, AC50. Extrapolated AC50s also include the highest efficacy observed and the concentration of compound at which it was observed.FloatμM
433Efficacy-Replicate_12Maximal efficacy of compound, reported as a percentage of control. These values are estimated based on fits of the Hill equation to the dose-response curves.Float%
434Analysis Comment-Replicate_12Annotation/notes on a particular compound's data or its analysis.String
435Activity_Score-Replicate_12Activity score.Integer
436Curve_Description-Replicate_12A description of dose-response curve quality. A complete curve has two observed asymptotes; a partial curve may not have attained its second asymptote at the highest concentration tested. High efficacy curves exhibit efficacy greater than 80% of control. Partial efficacies are statistically significant, but below 80% of control.String
437Fit_LogAC50-Replicate_12The logarithm of the AC50 from a fit of the data to the Hill equation (calculated based on Molar Units).Float
438Fit_HillSlope-Replicate_12The Hill slope from a fit of the data to the Hill equation.Float
439Fit_R2-Replicate_12R^2 fit value of the curve. Closer to 1.0 equates to better Hill equation fit.Float
440Fit_InfiniteActivity-Replicate_12The asymptotic efficacy from a fit of the data to the Hill equation.Float%
441Fit_ZeroActivity-Replicate_12Efficacy at zero concentration of compound from a fit of the data to the Hill equation.Float%
442Fit_CurveClass-Replicate_12Numerical encoding of curve description for the fitted Hill equation.Float
443Excluded_Points-Replicate_12Which dose-response titration points were excluded from analysis based on outlier analysis. Each number represents whether a titration point was (1) or was not (0) excluded, for the titration series going from smallest to highest compound concentrations.String
444Max_Response-Replicate_12Maximum activity observed for compound (usually at highest concentration tested).Float%
445Activity at 0.0000056507 uM-Replicate_12 (5.65069e-06μM**)% Activity at given concentration.Float%
446Activity at 0.0000126354 uM-Replicate_12 (1.26354e-05μM**)% Activity at given concentration.Float%
447Activity at 0.0000282534 uM-Replicate_12 (2.82534e-05μM**)% Activity at given concentration.Float%
448Activity at 0.0000545573 uM-Replicate_12 (5.45573e-05μM**)% Activity at given concentration.Float%
449Activity at 0.0001216490 uM-Replicate_12 (0.000121649μM**)% Activity at given concentration.Float%
450Activity at 0.0002748434 uM-Replicate_12 (0.000274843μM**)% Activity at given concentration.Float%
451Activity at 0.0005839002 uM-Replicate_12 (0.0005839μM**)% Activity at given concentration.Float%
452Activity at 0.00107 uM-Replicate_12 (0.00106551μM**)% Activity at given concentration.Float%
453Activity at 0.00238 uM-Replicate_12 (0.00237922μM**)% Activity at given concentration.Float%
454Activity at 0.00531 uM-Replicate_12 (0.00531238μM**)% Activity at given concentration.Float%
455Activity at 0.012 uM-Replicate_12 (0.0118656μM**)% Activity at given concentration.Float%
456Activity at 0.026 uM-Replicate_12 (0.0264438μM**)% Activity at given concentration.Float%
457Activity at 0.059 uM-Replicate_12 (0.0588928μM**)% Activity at given concentration.Float%
458Activity at 0.132 uM-Replicate_12 (0.131506μM**)% Activity at given concentration.Float%
459Activity at 0.275 uM-Replicate_12 (0.27546μM**)% Activity at given concentration.Float%
460Activity at 0.550 uM-Replicate_12 (0.54984μM**)% Activity at given concentration.Float%
461Activity at 1.224 uM-Replicate_12 (1.22441μM**)% Activity at given concentration.Float%
462Activity at 2.686 uM-Replicate_12 (2.68609μM**)% Activity at given concentration.Float%
463Activity at 5.948 uM-Replicate_12 (5.94817μM**)% Activity at given concentration.Float%
464Activity at 13.22 uM-Replicate_12 (13.2238μM**)% Activity at given concentration.Float%
465Activity at 29.14 uM-Replicate_12 (29.1394μM**)% Activity at given concentration.Float%
466Activity at 62.57 uM-Replicate_12 (62.5708μM**)% Activity at given concentration.Float%
467Activity at 81.11 uM-Replicate_12 (81.1055μM**)% Activity at given concentration.Float%
468Activity at 231.6 uM-Replicate_12 (231.639μM**)% Activity at given concentration.Float%
469Activity at 765.1 uM-Replicate_12 (765.1μM**)% Activity at given concentration.Float%
470Phenotype-Replicate_13Indicates type of activity observed: inhibitor, activator, fluorescent, cytotoxic, inactive, or inconclusive.String
471Potency-Replicate_13Concentration at which compound exhibits half-maximal efficacy, AC50. Extrapolated AC50s also include the highest efficacy observed and the concentration of compound at which it was observed.FloatμM
472Efficacy-Replicate_13Maximal efficacy of compound, reported as a percentage of control. These values are estimated based on fits of the Hill equation to the dose-response curves.Float%
473Analysis Comment-Replicate_13Annotation/notes on a particular compound's data or its analysis.String
474Activity_Score-Replicate_13Activity score.Integer
475Curve_Description-Replicate_13A description of dose-response curve quality. A complete curve has two observed asymptotes; a partial curve may not have attained its second asymptote at the highest concentration tested. High efficacy curves exhibit efficacy greater than 80% of control. Partial efficacies are statistically significant, but below 80% of control.String
476Fit_LogAC50-Replicate_13The logarithm of the AC50 from a fit of the data to the Hill equation (calculated based on Molar Units).Float
477Fit_HillSlope-Replicate_13The Hill slope from a fit of the data to the Hill equation.Float
478Fit_R2-Replicate_13R^2 fit value of the curve. Closer to 1.0 equates to better Hill equation fit.Float
479Fit_InfiniteActivity-Replicate_13The asymptotic efficacy from a fit of the data to the Hill equation.Float%
480Fit_ZeroActivity-Replicate_13Efficacy at zero concentration of compound from a fit of the data to the Hill equation.Float%
481Fit_CurveClass-Replicate_13Numerical encoding of curve description for the fitted Hill equation.Float
482Excluded_Points-Replicate_13Which dose-response titration points were excluded from analysis based on outlier analysis. Each number represents whether a titration point was (1) or was not (0) excluded, for the titration series going from smallest to highest compound concentrations.String
483Max_Response-Replicate_13Maximum activity observed for compound (usually at highest concentration tested).Float%
484Activity at 0.0000056507 uM-Replicate_13 (5.65069e-06μM**)% Activity at given concentration.Float%
485Activity at 0.0000126354 uM-Replicate_13 (1.26354e-05μM**)% Activity at given concentration.Float%
486Activity at 0.0000282534 uM-Replicate_13 (2.82534e-05μM**)% Activity at given concentration.Float%
487Activity at 0.0000545573 uM-Replicate_13 (5.45573e-05μM**)% Activity at given concentration.Float%
488Activity at 0.0001216490 uM-Replicate_13 (0.000121649μM**)% Activity at given concentration.Float%
489Activity at 0.0002748434 uM-Replicate_13 (0.000274843μM**)% Activity at given concentration.Float%
490Activity at 0.0005839002 uM-Replicate_13 (0.0005839μM**)% Activity at given concentration.Float%
491Activity at 0.00107 uM-Replicate_13 (0.00106551μM**)% Activity at given concentration.Float%
492Activity at 0.00238 uM-Replicate_13 (0.00237922μM**)% Activity at given concentration.Float%
493Activity at 0.00531 uM-Replicate_13 (0.00531238μM**)% Activity at given concentration.Float%
494Activity at 0.012 uM-Replicate_13 (0.0118656μM**)% Activity at given concentration.Float%
495Activity at 0.026 uM-Replicate_13 (0.0264438μM**)% Activity at given concentration.Float%
496Activity at 0.059 uM-Replicate_13 (0.0588928μM**)% Activity at given concentration.Float%
497Activity at 0.132 uM-Replicate_13 (0.131506μM**)% Activity at given concentration.Float%
498Activity at 0.275 uM-Replicate_13 (0.27546μM**)% Activity at given concentration.Float%
499Activity at 0.550 uM-Replicate_13 (0.54984μM**)% Activity at given concentration.Float%
500Activity at 1.224 uM-Replicate_13 (1.22441μM**)% Activity at given concentration.Float%
501Activity at 2.686 uM-Replicate_13 (2.68609μM**)% Activity at given concentration.Float%
502Activity at 5.948 uM-Replicate_13 (5.94817μM**)% Activity at given concentration.Float%
503Activity at 13.22 uM-Replicate_13 (13.2238μM**)% Activity at given concentration.Float%
504Activity at 29.14 uM-Replicate_13 (29.1394μM**)% Activity at given concentration.Float%
505Activity at 62.57 uM-Replicate_13 (62.5708μM**)% Activity at given concentration.Float%
506Activity at 81.11 uM-Replicate_13 (81.1055μM**)% Activity at given concentration.Float%
507Activity at 231.6 uM-Replicate_13 (231.639μM**)% Activity at given concentration.Float%
508Activity at 765.1 uM-Replicate_13 (765.1μM**)% Activity at given concentration.Float%
509Phenotype-Replicate_14Indicates type of activity observed: inhibitor, activator, fluorescent, cytotoxic, inactive, or inconclusive.String
510Potency-Replicate_14Concentration at which compound exhibits half-maximal efficacy, AC50. Extrapolated AC50s also include the highest efficacy observed and the concentration of compound at which it was observed.FloatμM
511Efficacy-Replicate_14Maximal efficacy of compound, reported as a percentage of control. These values are estimated based on fits of the Hill equation to the dose-response curves.Float%
512Analysis Comment-Replicate_14Annotation/notes on a particular compound's data or its analysis.String
513Activity_Score-Replicate_14Activity score.Integer
514Curve_Description-Replicate_14A description of dose-response curve quality. A complete curve has two observed asymptotes; a partial curve may not have attained its second asymptote at the highest concentration tested. High efficacy curves exhibit efficacy greater than 80% of control. Partial efficacies are statistically significant, but below 80% of control.String
515Fit_LogAC50-Replicate_14The logarithm of the AC50 from a fit of the data to the Hill equation (calculated based on Molar Units).Float
516Fit_HillSlope-Replicate_14The Hill slope from a fit of the data to the Hill equation.Float
517Fit_R2-Replicate_14R^2 fit value of the curve. Closer to 1.0 equates to better Hill equation fit.Float
518Fit_InfiniteActivity-Replicate_14The asymptotic efficacy from a fit of the data to the Hill equation.Float%
519Fit_ZeroActivity-Replicate_14Efficacy at zero concentration of compound from a fit of the data to the Hill equation.Float%
520Fit_CurveClass-Replicate_14Numerical encoding of curve description for the fitted Hill equation.Float
521Excluded_Points-Replicate_14Which dose-response titration points were excluded from analysis based on outlier analysis. Each number represents whether a titration point was (1) or was not (0) excluded, for the titration series going from smallest to highest compound concentrations.String
522Max_Response-Replicate_14Maximum activity observed for compound (usually at highest concentration tested).Float%
523Activity at 0.0000056507 uM-Replicate_14 (5.65069e-06μM**)% Activity at given concentration.Float%
524Activity at 0.0000126354 uM-Replicate_14 (1.26354e-05μM**)% Activity at given concentration.Float%
525Activity at 0.0000282534 uM-Replicate_14 (2.82534e-05μM**)% Activity at given concentration.Float%
526Activity at 0.0000545573 uM-Replicate_14 (5.45573e-05μM**)% Activity at given concentration.Float%
527Activity at 0.0001216490 uM-Replicate_14 (0.000121649μM**)% Activity at given concentration.Float%
528Activity at 0.0002748434 uM-Replicate_14 (0.000274843μM**)% Activity at given concentration.Float%
529Activity at 0.0005839002 uM-Replicate_14 (0.0005839μM**)% Activity at given concentration.Float%
530Activity at 0.00107 uM-Replicate_14 (0.00106551μM**)% Activity at given concentration.Float%
531Activity at 0.00238 uM-Replicate_14 (0.00237922μM**)% Activity at given concentration.Float%
532Activity at 0.00531 uM-Replicate_14 (0.00531238μM**)% Activity at given concentration.Float%
533Activity at 0.012 uM-Replicate_14 (0.0118656μM**)% Activity at given concentration.Float%
534Activity at 0.026 uM-Replicate_14 (0.0264438μM**)% Activity at given concentration.Float%
535Activity at 0.059 uM-Replicate_14 (0.0588928μM**)% Activity at given concentration.Float%
536Activity at 0.132 uM-Replicate_14 (0.131506μM**)% Activity at given concentration.Float%
537Activity at 0.275 uM-Replicate_14 (0.27546μM**)% Activity at given concentration.Float%
538Activity at 0.550 uM-Replicate_14 (0.54984μM**)% Activity at given concentration.Float%
539Activity at 1.224 uM-Replicate_14 (1.22441μM**)% Activity at given concentration.Float%
540Activity at 2.686 uM-Replicate_14 (2.68609μM**)% Activity at given concentration.Float%
541Activity at 5.948 uM-Replicate_14 (5.94817μM**)% Activity at given concentration.Float%
542Activity at 13.22 uM-Replicate_14 (13.2238μM**)% Activity at given concentration.Float%
543Activity at 29.14 uM-Replicate_14 (29.1394μM**)% Activity at given concentration.Float%
544Activity at 62.57 uM-Replicate_14 (62.5708μM**)% Activity at given concentration.Float%
545Activity at 81.11 uM-Replicate_14 (81.1055μM**)% Activity at given concentration.Float%
546Activity at 231.6 uM-Replicate_14 (231.639μM**)% Activity at given concentration.Float%
547Activity at 765.1 uM-Replicate_14 (765.1μM**)% Activity at given concentration.Float%
548Phenotype-Replicate_15Indicates type of activity observed: inhibitor, activator, fluorescent, cytotoxic, inactive, or inconclusive.String
549Potency-Replicate_15Concentration at which compound exhibits half-maximal efficacy, AC50. Extrapolated AC50s also include the highest efficacy observed and the concentration of compound at which it was observed.FloatμM
550Efficacy-Replicate_15Maximal efficacy of compound, reported as a percentage of control. These values are estimated based on fits of the Hill equation to the dose-response curves.Float%
551Analysis Comment-Replicate_15Annotation/notes on a particular compound's data or its analysis.String
552Activity_Score-Replicate_15Activity score.Integer
553Curve_Description-Replicate_15A description of dose-response curve quality. A complete curve has two observed asymptotes; a partial curve may not have attained its second asymptote at the highest concentration tested. High efficacy curves exhibit efficacy greater than 80% of control. Partial efficacies are statistically significant, but below 80% of control.String
554Fit_LogAC50-Replicate_15The logarithm of the AC50 from a fit of the data to the Hill equation (calculated based on Molar Units).Float
555Fit_HillSlope-Replicate_15The Hill slope from a fit of the data to the Hill equation.Float
556Fit_R2-Replicate_15R^2 fit value of the curve. Closer to 1.0 equates to better Hill equation fit.Float
557Fit_InfiniteActivity-Replicate_15The asymptotic efficacy from a fit of the data to the Hill equation.Float%
558Fit_ZeroActivity-Replicate_15Efficacy at zero concentration of compound from a fit of the data to the Hill equation.Float%
559Fit_CurveClass-Replicate_15Numerical encoding of curve description for the fitted Hill equation.Float
560Excluded_Points-Replicate_15Which dose-response titration points were excluded from analysis based on outlier analysis. Each number represents whether a titration point was (1) or was not (0) excluded, for the titration series going from smallest to highest compound concentrations.String
561Max_Response-Replicate_15Maximum activity observed for compound (usually at highest concentration tested).Float%
562Activity at 0.0000056507 uM-Replicate_15 (5.65069e-06μM**)% Activity at given concentration.Float%
563Activity at 0.0000126354 uM-Replicate_15 (1.26354e-05μM**)% Activity at given concentration.Float%
564Activity at 0.0000282534 uM-Replicate_15 (2.82534e-05μM**)% Activity at given concentration.Float%
565Activity at 0.0000545573 uM-Replicate_15 (5.45573e-05μM**)% Activity at given concentration.Float%
566Activity at 0.0001216490 uM-Replicate_15 (0.000121649μM**)% Activity at given concentration.Float%
567Activity at 0.0002748434 uM-Replicate_15 (0.000274843μM**)% Activity at given concentration.Float%
568Activity at 0.0005839002 uM-Replicate_15 (0.0005839μM**)% Activity at given concentration.Float%
569Activity at 0.00107 uM-Replicate_15 (0.00106551μM**)% Activity at given concentration.Float%
570Activity at 0.00238 uM-Replicate_15 (0.00237922μM**)% Activity at given concentration.Float%
571Activity at 0.00531 uM-Replicate_15 (0.00531238μM**)% Activity at given concentration.Float%
572Activity at 0.012 uM-Replicate_15 (0.0118656μM**)% Activity at given concentration.Float%
573Activity at 0.026 uM-Replicate_15 (0.0264438μM**)% Activity at given concentration.Float%
574Activity at 0.059 uM-Replicate_15 (0.0588928μM**)% Activity at given concentration.Float%
575Activity at 0.132 uM-Replicate_15 (0.131506μM**)% Activity at given concentration.Float%
576Activity at 0.275 uM-Replicate_15 (0.27546μM**)% Activity at given concentration.Float%
577Activity at 0.550 uM-Replicate_15 (0.54984μM**)% Activity at given concentration.Float%
578Activity at 1.224 uM-Replicate_15 (1.22441μM**)% Activity at given concentration.Float%
579Activity at 2.686 uM-Replicate_15 (2.68609μM**)% Activity at given concentration.Float%
580Activity at 5.948 uM-Replicate_15 (5.94817μM**)% Activity at given concentration.Float%
581Activity at 13.22 uM-Replicate_15 (13.2238μM**)% Activity at given concentration.Float%
582Activity at 29.14 uM-Replicate_15 (29.1394μM**)% Activity at given concentration.Float%
583Activity at 62.57 uM-Replicate_15 (62.5708μM**)% Activity at given concentration.Float%
584Activity at 81.11 uM-Replicate_15 (81.1055μM**)% Activity at given concentration.Float%
585Activity at 231.6 uM-Replicate_15 (231.639μM**)% Activity at given concentration.Float%
586Activity at 765.1 uM-Replicate_15 (765.1μM**)% Activity at given concentration.Float%
587Phenotype-Replicate_16Indicates type of activity observed: inhibitor, activator, fluorescent, cytotoxic, inactive, or inconclusive.String
588Potency-Replicate_16Concentration at which compound exhibits half-maximal efficacy, AC50. Extrapolated AC50s also include the highest efficacy observed and the concentration of compound at which it was observed.FloatμM
589Efficacy-Replicate_16Maximal efficacy of compound, reported as a percentage of control. These values are estimated based on fits of the Hill equation to the dose-response curves.Float%
590Analysis Comment-Replicate_16Annotation/notes on a particular compound's data or its analysis.String
591Activity_Score-Replicate_16Activity score.Integer
592Curve_Description-Replicate_16A description of dose-response curve quality. A complete curve has two observed asymptotes; a partial curve may not have attained its second asymptote at the highest concentration tested. High efficacy curves exhibit efficacy greater than 80% of control. Partial efficacies are statistically significant, but below 80% of control.String
593Fit_LogAC50-Replicate_16The logarithm of the AC50 from a fit of the data to the Hill equation (calculated based on Molar Units).Float
594Fit_HillSlope-Replicate_16The Hill slope from a fit of the data to the Hill equation.Float
595Fit_R2-Replicate_16R^2 fit value of the curve. Closer to 1.0 equates to better Hill equation fit.Float
596Fit_InfiniteActivity-Replicate_16The asymptotic efficacy from a fit of the data to the Hill equation.Float%
597Fit_ZeroActivity-Replicate_16Efficacy at zero concentration of compound from a fit of the data to the Hill equation.Float%
598Fit_CurveClass-Replicate_16Numerical encoding of curve description for the fitted Hill equation.Float
599Excluded_Points-Replicate_16Which dose-response titration points were excluded from analysis based on outlier analysis. Each number represents whether a titration point was (1) or was not (0) excluded, for the titration series going from smallest to highest compound concentrations.String
600Max_Response-Replicate_16Maximum activity observed for compound (usually at highest concentration tested).Float%
601Activity at 0.0000056507 uM-Replicate_16 (5.65069e-06μM**)% Activity at given concentration.Float%
602Activity at 0.0000126354 uM-Replicate_16 (1.26354e-05μM**)% Activity at given concentration.Float%
603Activity at 0.0000282534 uM-Replicate_16 (2.82534e-05μM**)% Activity at given concentration.Float%
604Activity at 0.0000545573 uM-Replicate_16 (5.45573e-05μM**)% Activity at given concentration.Float%
605Activity at 0.0001216490 uM-Replicate_16 (0.000121649μM**)% Activity at given concentration.Float%
606Activity at 0.0002748434 uM-Replicate_16 (0.000274843μM**)% Activity at given concentration.Float%
607Activity at 0.0005839002 uM-Replicate_16 (0.0005839μM**)% Activity at given concentration.Float%
608Activity at 0.00107 uM-Replicate_16 (0.00106551μM**)% Activity at given concentration.Float%
609Activity at 0.00238 uM-Replicate_16 (0.00237922μM**)% Activity at given concentration.Float%
610Activity at 0.00531 uM-Replicate_16 (0.00531238μM**)% Activity at given concentration.Float%
611Activity at 0.012 uM-Replicate_16 (0.0118656μM**)% Activity at given concentration.Float%
612Activity at 0.026 uM-Replicate_16 (0.0264438μM**)% Activity at given concentration.Float%
613Activity at 0.059 uM-Replicate_16 (0.0588928μM**)% Activity at given concentration.Float%
614Activity at 0.132 uM-Replicate_16 (0.131506μM**)% Activity at given concentration.Float%
615Activity at 0.275 uM-Replicate_16 (0.27546μM**)% Activity at given concentration.Float%
616Activity at 0.550 uM-Replicate_16 (0.54984μM**)% Activity at given concentration.Float%
617Activity at 1.224 uM-Replicate_16 (1.22441μM**)% Activity at given concentration.Float%
618Activity at 2.686 uM-Replicate_16 (2.68609μM**)% Activity at given concentration.Float%
619Activity at 5.948 uM-Replicate_16 (5.94817μM**)% Activity at given concentration.Float%
620Activity at 13.22 uM-Replicate_16 (13.2238μM**)% Activity at given concentration.Float%
621Activity at 29.14 uM-Replicate_16 (29.1394μM**)% Activity at given concentration.Float%
622Activity at 62.57 uM-Replicate_16 (62.5708μM**)% Activity at given concentration.Float%
623Activity at 81.11 uM-Replicate_16 (81.1055μM**)% Activity at given concentration.Float%
624Activity at 231.6 uM-Replicate_16 (231.639μM**)% Activity at given concentration.Float%
625Activity at 765.1 uM-Replicate_16 (765.1μM**)% Activity at given concentration.Float%
626Phenotype-Replicate_17Indicates type of activity observed: inhibitor, activator, fluorescent, cytotoxic, inactive, or inconclusive.String
627Potency-Replicate_17Concentration at which compound exhibits half-maximal efficacy, AC50. Extrapolated AC50s also include the highest efficacy observed and the concentration of compound at which it was observed.FloatμM
628Efficacy-Replicate_17Maximal efficacy of compound, reported as a percentage of control. These values are estimated based on fits of the Hill equation to the dose-response curves.Float%
629Analysis Comment-Replicate_17Annotation/notes on a particular compound's data or its analysis.String
630Activity_Score-Replicate_17Activity score.Integer
631Curve_Description-Replicate_17A description of dose-response curve quality. A complete curve has two observed asymptotes; a partial curve may not have attained its second asymptote at the highest concentration tested. High efficacy curves exhibit efficacy greater than 80% of control. Partial efficacies are statistically significant, but below 80% of control.String
632Fit_LogAC50-Replicate_17The logarithm of the AC50 from a fit of the data to the Hill equation (calculated based on Molar Units).Float
633Fit_HillSlope-Replicate_17The Hill slope from a fit of the data to the Hill equation.Float
634Fit_R2-Replicate_17R^2 fit value of the curve. Closer to 1.0 equates to better Hill equation fit.Float
635Fit_InfiniteActivity-Replicate_17The asymptotic efficacy from a fit of the data to the Hill equation.Float%
636Fit_ZeroActivity-Replicate_17Efficacy at zero concentration of compound from a fit of the data to the Hill equation.Float%
637Fit_CurveClass-Replicate_17Numerical encoding of curve description for the fitted Hill equation.Float
638Excluded_Points-Replicate_17Which dose-response titration points were excluded from analysis based on outlier analysis. Each number represents whether a titration point was (1) or was not (0) excluded, for the titration series going from smallest to highest compound concentrations.String
639Max_Response-Replicate_17Maximum activity observed for compound (usually at highest concentration tested).Float%
640Activity at 0.0000056507 uM-Replicate_17 (5.65069e-06μM**)% Activity at given concentration.Float%
641Activity at 0.0000126354 uM-Replicate_17 (1.26354e-05μM**)% Activity at given concentration.Float%
642Activity at 0.0000282534 uM-Replicate_17 (2.82534e-05μM**)% Activity at given concentration.Float%
643Activity at 0.0000545573 uM-Replicate_17 (5.45573e-05μM**)% Activity at given concentration.Float%
644Activity at 0.0001216490 uM-Replicate_17 (0.000121649μM**)% Activity at given concentration.Float%
645Activity at 0.0002748434 uM-Replicate_17 (0.000274843μM**)% Activity at given concentration.Float%
646Activity at 0.0005839002 uM-Replicate_17 (0.0005839μM**)% Activity at given concentration.Float%
647Activity at 0.00107 uM-Replicate_17 (0.00106551μM**)% Activity at given concentration.Float%
648Activity at 0.00238 uM-Replicate_17 (0.00237922μM**)% Activity at given concentration.Float%
649Activity at 0.00531 uM-Replicate_17 (0.00531238μM**)% Activity at given concentration.Float%
650Activity at 0.012 uM-Replicate_17 (0.0118656μM**)% Activity at given concentration.Float%
651Activity at 0.026 uM-Replicate_17 (0.0264438μM**)% Activity at given concentration.Float%
652Activity at 0.059 uM-Replicate_17 (0.0588928μM**)% Activity at given concentration.Float%
653Activity at 0.132 uM-Replicate_17 (0.131506μM**)% Activity at given concentration.Float%
654Activity at 0.275 uM-Replicate_17 (0.27546μM**)% Activity at given concentration.Float%
655Activity at 0.550 uM-Replicate_17 (0.54984μM**)% Activity at given concentration.Float%
656Activity at 1.224 uM-Replicate_17 (1.22441μM**)% Activity at given concentration.Float%
657Activity at 2.686 uM-Replicate_17 (2.68609μM**)% Activity at given concentration.Float%
658Activity at 5.948 uM-Replicate_17 (5.94817μM**)% Activity at given concentration.Float%
659Activity at 13.22 uM-Replicate_17 (13.2238μM**)% Activity at given concentration.Float%
660Activity at 29.14 uM-Replicate_17 (29.1394μM**)% Activity at given concentration.Float%
661Activity at 62.57 uM-Replicate_17 (62.5708μM**)% Activity at given concentration.Float%
662Activity at 81.11 uM-Replicate_17 (81.1055μM**)% Activity at given concentration.Float%
663Activity at 231.6 uM-Replicate_17 (231.639μM**)% Activity at given concentration.Float%
664Activity at 765.1 uM-Replicate_17 (765.1μM**)% Activity at given concentration.Float%
665Phenotype-Replicate_18Indicates type of activity observed: inhibitor, activator, fluorescent, cytotoxic, inactive, or inconclusive.String
666Potency-Replicate_18Concentration at which compound exhibits half-maximal efficacy, AC50. Extrapolated AC50s also include the highest efficacy observed and the concentration of compound at which it was observed.FloatμM
667Efficacy-Replicate_18Maximal efficacy of compound, reported as a percentage of control. These values are estimated based on fits of the Hill equation to the dose-response curves.Float%
668Analysis Comment-Replicate_18Annotation/notes on a particular compound's data or its analysis.String
669Activity_Score-Replicate_18Activity score.Integer
670Curve_Description-Replicate_18A description of dose-response curve quality. A complete curve has two observed asymptotes; a partial curve may not have attained its second asymptote at the highest concentration tested. High efficacy curves exhibit efficacy greater than 80% of control. Partial efficacies are statistically significant, but below 80% of control.String
671Fit_LogAC50-Replicate_18The logarithm of the AC50 from a fit of the data to the Hill equation (calculated based on Molar Units).Float
672Fit_HillSlope-Replicate_18The Hill slope from a fit of the data to the Hill equation.Float
673Fit_R2-Replicate_18R^2 fit value of the curve. Closer to 1.0 equates to better Hill equation fit.Float
674Fit_InfiniteActivity-Replicate_18The asymptotic efficacy from a fit of the data to the Hill equation.Float%
675Fit_ZeroActivity-Replicate_18Efficacy at zero concentration of compound from a fit of the data to the Hill equation.Float%
676Fit_CurveClass-Replicate_18Numerical encoding of curve description for the fitted Hill equation.Float
677Excluded_Points-Replicate_18Which dose-response titration points were excluded from analysis based on outlier analysis. Each number represents whether a titration point was (1) or was not (0) excluded, for the titration series going from smallest to highest compound concentrations.String
678Max_Response-Replicate_18Maximum activity observed for compound (usually at highest concentration tested).Float%
679Activity at 0.0000056507 uM-Replicate_18 (5.65069e-06μM**)% Activity at given concentration.Float%
680Activity at 0.0000126354 uM-Replicate_18 (1.26354e-05μM**)% Activity at given concentration.Float%
681Activity at 0.0000282534 uM-Replicate_18 (2.82534e-05μM**)% Activity at given concentration.Float%
682Activity at 0.0000545573 uM-Replicate_18 (5.45573e-05μM**)% Activity at given concentration.Float%
683Activity at 0.0001216490 uM-Replicate_18 (0.000121649μM**)% Activity at given concentration.Float%
684Activity at 0.0002748434 uM-Replicate_18 (0.000274843μM**)% Activity at given concentration.Float%
685Activity at 0.0005839002 uM-Replicate_18 (0.0005839μM**)% Activity at given concentration.Float%
686Activity at 0.00107 uM-Replicate_18 (0.00106551μM**)% Activity at given concentration.Float%
687Activity at 0.00238 uM-Replicate_18 (0.00237922μM**)% Activity at given concentration.Float%
688Activity at 0.00531 uM-Replicate_18 (0.00531238μM**)% Activity at given concentration.Float%
689Activity at 0.012 uM-Replicate_18 (0.0118656μM**)% Activity at given concentration.Float%
690Activity at 0.026 uM-Replicate_18 (0.0264438μM**)% Activity at given concentration.Float%
691Activity at 0.059 uM-Replicate_18 (0.0588928μM**)% Activity at given concentration.Float%
692Activity at 0.132 uM-Replicate_18 (0.131506μM**)% Activity at given concentration.Float%
693Activity at 0.275 uM-Replicate_18 (0.27546μM**)% Activity at given concentration.Float%
694Activity at 0.550 uM-Replicate_18 (0.54984μM**)% Activity at given concentration.Float%
695Activity at 1.224 uM-Replicate_18 (1.22441μM**)% Activity at given concentration.Float%
696Activity at 2.686 uM-Replicate_18 (2.68609μM**)% Activity at given concentration.Float%
697Activity at 5.948 uM-Replicate_18 (5.94817μM**)% Activity at given concentration.Float%
698Activity at 13.22 uM-Replicate_18 (13.2238μM**)% Activity at given concentration.Float%
699Activity at 29.14 uM-Replicate_18 (29.1394μM**)% Activity at given concentration.Float%
700Activity at 62.57 uM-Replicate_18 (62.5708μM**)% Activity at given concentration.Float%
701Activity at 81.11 uM-Replicate_18 (81.1055μM**)% Activity at given concentration.Float%
702Activity at 231.6 uM-Replicate_18 (231.639μM**)% Activity at given concentration.Float%
703Activity at 765.1 uM-Replicate_18 (765.1μM**)% Activity at given concentration.Float%

* Activity Concentration. ** Test Concentration.

Data Table (Concise)
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