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BioAssay: AID 742965

Glutathione reductase inhibitor

This assay is created using drug mechanism and related information provided by ChEMBL. "INHIBITOR": Negatively effects (inhibits) the normal functioning of the protein e.g., prevention of enzymatic reaction or activation of downstream pathway. ..more
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 Tested Compounds
 Tested Compounds
All(1)
 
 
Active(1)
 
 
 Tested Substances
 Tested Substances
All(1)
 
 
Active(1)
 
 
 Related BioAssays
 Related BioAssays
AID: 742965
Data Source: ChEMBL (drug_mech_933)
Depositor Category: Other
BioAssay Version:
Deposit Date: 2013-11-07
Modify Date: 2014-05-05

Data Table ( Complete ):           Active    All
Target
Sequence: RecName: Full=Glutathione reductase, mitochondrial; Short=GR; Short=GRase; Flags: Precursor
Description ..   
Protein Family: Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
Comment ..   

Gene:GSR     Related Protein 3D Structures     More BioActivity Data..
BioActive Compound: 1
Description:
This assay is created using drug mechanism and related information provided by ChEMBL. "INHIBITOR": Negatively effects (inhibits) the normal functioning of the protein e.g., prevention of enzymatic reaction or activation of downstream pathway.
Categorized Comment
Drug Action Type: INHIBITOR

Assay Data Source: Drug Mechanism

Target Type: Target is a single protein chain

Protein Target Class: enzyme reductase

Result Definitions
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TIDNameDescriptionAnnotationHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1MEC_IDDrug Mechanism IDInteger
2Action TypeType of action of the drug on the targetString
3Direct InteractionFlag to show whether the molecule is believed to interact directly with the targetString
4Molecular MechanismFlag to show whether the mechanism of action describes the molecular target of the drug, rather than a higher-level physiological mechanismString
5Disease EfficacyFlag to show whether the target assigned is believed to play a role in the efficacy of the drug in the indication(s) for which it is approvedString
6PubMed IDsPubMed IDs referred to the drug on the targetPMIDString
7WHO NameWHO/INN name for the compoundString
8Level1 DescriptionDescription of first level of WHO ATC classificationString
9Level2 DescriptionDescription of second level of WHO ATC classificationString
10Level3 DescriptionDescription of third level of WHO ATC classificationString
11Level4 DescriptionDescription of fourth level of WHO ATC classificationString

Data Table (Concise)
Classification
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