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BioAssay: AID 717321

Binding affinity to human recombinant cathepsin S assessed as compound-enzyme half life

Cysteine cathepsins play an important role in many (patho)physiological conditions. Among them, cathepsins L, S, K and B are subjects of several drug discovery programs. Besides their role as drug targets, cysteine cathepsins are additionally considered to be possible biomarkers for inflammation and cancer. Herein, we describe the design, synthesis, biological evaluation and spectral properties of fluorescently labeled dipeptide- and azadipeptide nitriles. ..more
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 Tested Compounds
 Tested Compounds
All(1)
 
 
Unspecified(1)
 
 
 Tested Substances
 Tested Substances
All(1)
 
 
Unspecified(1)
 
 
 Related BioAssays
 Related BioAssays
AID: 717321
Data Source: ChEMBL (885064)
Depositor Category: Literature, Extracted
BioAssay Version:
Deposit Date: 2013-06-29
Modify Date: 2014-05-26

Data Table ( Complete ):           View All Data
Target
Sequence: RecName: Full=Cathepsin S; Flags: Precursor
Description ..   
Protein Family: Peptidase_C1A
Comment ..   

Gene:CTSS     Related Protein 3D Structures     More BioActivity Data..
Tested Compound:
Description:
Title: Fluorescent nitrile-based inhibitors of cysteine cathepsins.

Abstract: Cysteine cathepsins play an important role in many (patho)physiological conditions. Among them, cathepsins L, S, K and B are subjects of several drug discovery programs. Besides their role as drug targets, cysteine cathepsins are additionally considered to be possible biomarkers for inflammation and cancer. Herein, we describe the design, synthesis, biological evaluation and spectral properties of fluorescently labeled dipeptide- and azadipeptide nitriles.
(PMID: 23122525)
Categorized Comment
Assay Type: Binding

Assay Data Source: Scientific Literature

BAO: Assay Format: biochemical format

Target Type: Target is a single protein chain

Result Definitions
TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1T1/2 activity commentT1/2 activity commentString
2T1/2 standard flagT1/2 standard flagInteger
3T1/2 qualifierT1/2 qualifierString
4T1/2 published valueT1/2 published valueFloathr
5T1/2 standard valueT1/2 standard valueFloathr

Data Table (Concise)
Data Table ( Complete ):     View All Data
Classification
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