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BioAssay: AID 686926

ML354 Eurofin Panel Assay for PAR4 Antagonists Inhibitor (Probe Compound)

Methods employed in this study have been adapted from the scientific literature to maximize reliability and reproducibility.Reference standards were run as an integral part of each assay to ensure the validity of the results obtained. Assays were performed under conditions described in the accompanying "Methods" section of this report.Where presented, IC50 values were determined by a non-linear, more ..
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 Tested Compounds
 Tested Compounds
All(1)
 
 
Inactive(1)
 
 
 Tested Substances
 Tested Substances
All(1)
 
 
Inactive(1)
 
 
AID: 686926
Data Source: Vanderbilt Specialized Chemistry Center (Radioligand Binding assays (Eurofin) ML354 VU704-PAR4 (VU-23..)
BioAssay Type: Panel
Depositor Category: NIH Molecular Libraries Probe Production Network
Deposit Date: 2013-04-10
Hold-until Date: 2014-04-08
Modify Date: 2014-04-08

Data Table ( Complete ):           All
Tested Compound:
Depositor Specified Assays
AIDNameTypeComment
652261ML354 Discovery of Novel Antagonists of Protease activated receptor 4summary
Description:
Assay Provider: P Jeffrey Conn

Assay Provider Affiliation: Vanderbilt University

Methods employed in this study have been adapted from the scientific literature to maximize reliability and reproducibility.Reference standards were run as an integral part of each assay to ensure the validity of the results obtained. Assays were performed under conditions described in the accompanying "Methods" section of this report.Where presented, IC50 values were determined by a non-linear, least squares regression analysis using MathIQTM (IDBusiness Solutions Ltd., UK). Where inhibition constants (Ki) are presented, the Ki values were calculated using theequation of Cheng and Prusoff (Cheng, Y., Prusoff, W.H., Biochem. Pharmacol. 22:3099-3108, 1973) using the observed IC50 of the tested compound, the concentration of radioligand employed in the assay, and the historical values for the KD of the ligand (obtained experimentally at Eurofins Panlabs, Inc.). Where presented, the Hill coefficient (nH),defining the slope of the competitive binding curve, was calculated using MathIQTM. Hill coefficients significantly different than 1.0, may suggest that the binding displacement does not follow the laws of mass action with a single binding site.Where IC50, Ki, and/or nH data are presented without Standard Error of the Mean (SEM), data are insufficient to be quantitative, and the values presented (Ki, IC50, nH) should be interpreted with caution.

Panel Information
PAR4_Eurofin_Panel
    Data Table(All)Show more
PID§NameSubstancePanel TargetsDescriptionAdditional Information
ActiveInactive
1Eurofin Panel Assays for mGlur5 SAM Probe1Adenosine_A1 [gi:4501947]
Radioligand Binding AssayTaxonomy id: 9606
2Eurofin Panel Assays for mGlur5 SAM Probe1Adenosine_A2A [gi:5921992]
Radioligand Binding AssayTaxonomy id: 9606
3Eurofin Panel Assays for mGlur5 SAM Probe1Adenosine_A3 [gi:4501953]
Radioligand Binding AssayTaxonomy id: 9606
4Eurofin Panel Assays for mGlur5 SAM Probe1Adrenergic_alpha1A [gi:148747171]
Radioligand Binding AssayTaxonomy id: 10116
5Eurofin Panel Assays for mGlur5 SAM Probe1Adrenergic_alpha1B [gi:47575853]
Radioligand Binding AssayTaxonomy id: 10116
6Eurofin Panel Assays for mGlur5 SAM Probe1Adrenergic_alpha1D [gi:13324696]
Radioligand Binding AssayTaxonomy id: 9606
7Eurofin Panel Assays for mGlur5 SAM Probe1Adrenergic_alpha2A [gi:194353970]
Radioligand Binding AssayTaxonomy id: 9606
8Eurofin Panel Assays for mGlur5 SAM Probe1Adrenergic_beta1 [gi:4557265]
Radioligand Binding AssayTaxonomy id: 9606
9Eurofin Panel Assays for mGlur5 SAM Probe1Adrenergic_beta2 [gi:4501969]
Radioligand Binding AssayTaxonomy id: 9606
10Eurofin Panel Assays for mGlur5 SAM Probe1Transporter_Norepinephrine_(NET) [gi:4335929]
Radioligand Binding AssayTaxonomy id: 9606
11Eurofin Panel Assays for mGlur5 SAM Probe1Bradykinin_B1 [gi:20544172]
Radioligand Binding AssayTaxonomy id: 9606
12Eurofin Panel Assays for mGlur5 SAM Probe1Bradykinin_B2 [gi:4557359]
Radioligand Binding AssayTaxonomy id: 9606
13Eurofin Panel Assays for mGlur5 SAM Probe1Calcium_Channel_L-Type_Benzothiazepine [gi:120433602]
Radioligand Binding AssayTaxonomy id: 10116
14Eurofin Panel Assays for mGlur5 SAM Probe1Calcium_Channel_L-Type_Dihydropyridine [gi:110349767]
Radioligand Binding AssayTaxonomy id: 10116
15Eurofin Panel Assays for mGlur5 SAM Probe1Calcium_Channel_N-Type [gi:110225368]
Radioligand Binding AssayTaxonomy id: 10116
16Eurofin Panel Assays for mGlur5 SAM Probe1Cannabinoid_CB1 [gi:237681173]
Radioligand Binding AssayTaxonomy id: 9606
17Eurofin Panel Assays for mGlur5 SAM Probe1Dopamine_D1 [gi:4502929]
Radioligand Binding AssayTaxonomy id: 9606
18Eurofin Panel Assays for mGlur5 SAM Probe1Dopamine_D2S [gi:299687]
Radioligand Binding AssayTaxonomy id: 9606
19Eurofin Panel Assays for mGlur5 SAM Probe1Dopamine_D3 [gi:553261]
Radioligand Binding AssayTaxonomy id: 9606
20Eurofin Panel Assays for mGlur5 SAM Probe1Dopamine_D4.2 [gi:1835973]
Radioligand Binding AssayTaxonomy id: 9606
21Eurofin Panel Assays for mGlur5 SAM Probe1Transporter_Dopamine_(DAT) [gi:256313]
Radioligand Binding AssayTaxonomy id: 9606
22Eurofin Panel Assays for mGlur5 SAM Probe1Endothelin_ETA [gi:238636]
Radioligand Binding AssayTaxonomy id: 9606
23Eurofin Panel Assays for mGlur5 SAM Probe1Endothelin_ETB [gi:4557547]
Radioligand Binding AssayTaxonomy id: 9606
24Eurofin Panel Assays for mGlur5 SAM Probe1Epidermal_Growth Factor_(EGF) [gi:46242544]
Radioligand Binding AssayTaxonomy id: 9606
25Eurofin Panel Assays for mGlur5 SAM Probe1Estrogen_ERalpha [gi:62821794]
Radioligand Binding AssayTaxonomy id: 9606
26Eurofin Panel Assays for mGlur5 SAM Probe1Transporter_GABA [gi:31658]
Radioligand Binding AssayTaxonomy id: 10116
27Eurofin Panel Assays for mGlur5 SAM Probe1GABAA_Muscimol_Central [gi:510878]
Radioligand Binding AssayTaxonomy id: 10116
28Eurofin Panel Assays for mGlur5 SAM Probe1GABAB1A [gi:3776073]
Radioligand Binding AssayTaxonomy id: 9606
29Eurofin Panel Assays for mGlur5 SAM Probe1Glucocorticoid [gi:239758]
Radioligand Binding AssayTaxonomy id: 9606
30Eurofin Panel Assays for mGlur5 SAM Probe1Glutamate_Kainate [gi:163659915]
Radioligand Binding AssayTaxonomy id: 10116
31Eurofin Panel Assays for mGlur5 SAM Probe1Glutamate_NMDA_Agonism [gi:8393484]
Radioligand Binding AssayTaxonomy id: 10116
32Eurofin Panel Assays for mGlur5 SAM Probe1Histamine_H1 [gi:149158709]
Radioligand Binding AssayTaxonomy id: 9606
33Eurofin Panel Assays for mGlur5 SAM Probe1Histamine_H2 [gi:5881576]
Radioligand Binding AssayTaxonomy id: 9606
34Eurofin Panel Assays for mGlur5 SAM Probe1Histamine_H3 [gi:194018562]
Radioligand Binding AssayTaxonomy id: 9606
35Eurofin Panel Assays for mGlur5 SAM Probe1Imidazoline_I2_Central [gi:205829312]
Radioligand Binding AssayTaxonomy id: 10116
36Eurofin Panel Assays for mGlur5 SAM Probe1Interleukin_IL-1 [gi:309398]
Radioligand Binding AssayTaxonomy id: 10090
37Eurofin Panel Assays for mGlur5 SAM Probe1Leukotriene_Cysteinyl_CysLT1 [gi:5729798]
Radioligand Binding AssayTaxonomy id: 9606
38Eurofin Panel Assays for mGlur5 SAM Probe1Melatonin_MT1 [gi:5174593]
Radioligand Binding AssayTaxonomy id: 9606
39Eurofin Panel Assays for mGlur5 SAM Probe1Muscarinic_M1 [gi:37622910]
Radioligand Binding AssayTaxonomy id: 9606
40Eurofin Panel Assays for mGlur5 SAM Probe1Muscarinic_M2 [gi:54792115]
Radioligand Binding AssayTaxonomy id: 9606
41Eurofin Panel Assays for mGlur5 SAM Probe1Muscarinic_M3 [gi:4502819]
Radioligand Binding AssayTaxonomy id: 9606
42Eurofin Panel Assays for mGlur5 SAM Probe1Tachykinin_NK1 [gi:38565061]
Radioligand Binding AssayTaxonomy id: 9606
43Eurofin Panel Assays for mGlur5 SAM Probe1Neuropeptide_YY1 [gi:1247453]
Radioligand Binding AssayTaxonomy id: 9606
44Eurofin Panel Assays for mGlur5 SAM Probe1Neuropeptide_YY2 [gi:29824918]
Radioligand Binding AssayTaxonomy id: 9606
45Eurofin Panel Assays for mGlur5 SAM Probe1Nicotinic_Acetylcholine [gi:308153405]
Radioligand Binding AssayTaxonomy id: 9606
46Eurofin Panel Assays for mGlur5 SAM Probe1Nicotinic_Acetylcholine_Alpha1_Bungarotoxin [gi:87567783]
Radioligand Binding AssayTaxonomy id: 9606
47Eurofin Panel Assays for mGlur5 SAM Probe1Opiate_delta1 _(OP1, DOP) [gi:501145]
Radioligand Binding AssayTaxonomy id: 9606
48Eurofin Panel Assays for mGlur5 SAM Probe1Opiate_kappa_(OP2, KOP) [gi:39986053]
Radioligand Binding AssayTaxonomy id: 9606
49Eurofin Panel Assays for mGlur5 SAM Probe1Opiate_mu_(OP3, MOP) [gi:452073]
Radioligand Binding AssayTaxonomy id: 9606
50Eurofin Panel Assays for mGlur5 SAM Probe1Phorbol_Ester [gi:12230239]
Radioligand Binding AssayTaxonomy id: 10090
51Eurofin Panel Assays for mGlur5 SAM Probe1Platelet_Activating_Factor _(PAF) [gi:190015]
Radioligand Binding AssayTaxonomy id: 9606
52Eurofin Panel Assays for mGlur5 SAM Probe1Potassium_Channel_[KATP] [gi:619879]
Radioligand Binding AssayTaxonomy id: 9606
53Eurofin Panel Assays for mGlur5 SAM Probe1Potassium_Channel_hERG [gi:37499017]
Radioligand Binding AssayTaxonomy id: 9606
54Eurofin Panel Assays for mGlur5 SAM Probe1Prostanoid_EP4 [gi:4506259]
Radioligand Binding AssayTaxonomy id: 9606
55Eurofin Panel Assays for mGlur5 SAM Probe1Purinergic_P2X [gi:291406943]
Radioligand Binding AssayTaxonomy id: 9986
56Eurofin Panel Assays for mGlur5 SAM Probe1Purinergic_P2Y [gi:25742733]
Radioligand Binding AssayTaxonomy id: 10116
57Eurofin Panel Assays for mGlur5 SAM Probe1Rolipram [gi:158518444]
Radioligand Binding AssayTaxonomy id: 10116
58Eurofin Panel Assays for mGlur5 SAM Probe1Serotonin_(5-Hydroxytryptamine)_5-HT1A [gi:36429]
Radioligand Binding AssayTaxonomy id: 9606
59Eurofin Panel Assays for mGlur5 SAM Probe1Serotonin_(5-Hydroxytryptamine)_5-HT2B [gi:219679]
Radioligand Binding AssayTaxonomy id: 9606
60Eurofin Panel Assays for mGlur5 SAM Probe1Serotonin_(5-Hydroxytryptamine)_5-HT3 [gi:3115222]
Radioligand Binding AssayTaxonomy id: 9606
61Eurofin Panel Assays for mGlur5 SAM Probe1Transporter_Serotonin_(5-Hydroxytryptamine)_(SERT) [gi:4507043]
Radioligand Binding AssayTaxonomy id: 9606
62Eurofin Panel Assays for mGlur5 SAM Probe1Sigma1 [gi:5733130]
Radioligand Binding AssayTaxonomy id: 9606
63Eurofin Panel Assays for mGlur5 SAM Probe1Sodium _Channel_Site_2 [gi:3097314]
Radioligand Binding AssayTaxonomy id: 10116
64Eurofin Panel Assays for mGlur5 SAM Probe1Androgen_(Testosterone)_AR [gi:178882]
Radioligand Binding AssayTaxonomy id: 10116
65Eurofin Panel Assays for mGlur5 SAM Probe1Thyroid_Hormone [gi:235280]
Radioligand Binding AssayTaxonomy id: 10116

§ Panel component ID.
Protocol
Biochemical assay results are presented as the percent inhibition of specific binding or activity throughout the report. All other results are expressed in terms of that assay's quantitation method.1:For primary assays, only the lowest concentration with a significant response judged by the assays' criteria, is shownin this summary.2:Where applicable, either the secondary assay results with the lowest dose/concentration meeting the significance criteria or, if inactive, the highest dose/concentration that did not meet the significance criteria is shown.3:Unless otherwise requested, primary screening in duplicate with quantitative data (e.g., IC50 +/- SEM, Ki +/- SEM and nH)are shown where applicable for individual requested assays. In screening packages, primary screening in duplicate with semi-quantitative data (e.g., estimated IC50, Ki and nH) are shown where applicable (concentration range of 4 log units);available secondary functional assays are carried out (30 mM) and MEC or MIC determined only if active in primary assays >50% at 1 log unit below initial test concentration.Significant responses (>/= 50% inhibition or stimulation for Biochemical assays) were noted in the primary assays listed below: Serotonin 5HT2B, Dopamine Transporter, Norepinephrine Transporter












Result Definitions
Show more
TIDNameDescriptionPID§Panel TargetsHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1Adenosine_A1_Percent_InhibitionPercent Inhibition1Adenosine_A1Float%
2Adenosine_A1_OutcomeActive/Inactive1Outcome
3Adenosine_A2A_Percent_InhibitionPercent Inhibition2Adenosine_A2AFloat%
4Adenosine_A2A_OutcomeActive/Inactive2Outcome
5Adenosine_A3_Percent_InhibitionPercent Inhibition3Adenosine_A3Float%
6Adenosine_A3_OutcomeActive/Inactive3Outcome
7Adrenergic_alpha1A_Percent_InhibitionPercent Inhibition4Adrenergic_alpha1AFloat%
8Adrenergic_alpha1A_OutcomeActive/Inactive4Outcome
9Adrenergic_alpha1B__Percent_InhibitionPercent Inhibition5Adrenergic_alpha1BFloat%
10Adrenergic_alpha1B__OutcomeActive/Inactive5Outcome
11Adrenergic_alpha1D_Percent_InhibitionPercent Inhibition6Adrenergic_alpha1DFloat%
12Adrenergic_alpha1D_OutcomeActive/Inactive6Outcome
13Adrenergic_alpha2A_Percent_InhibitionPercent Inhibition7Adrenergic_alpha2AFloat%
14Adrenergic_alpha2A_OutcomeActive/Inactive7Outcome
15Adrenergic_beta1_Percent_InhibitionPercent Inhibition8Adrenergic_beta1Float%
16Adrenergic_beta1_OutcomeActive/Inactive8Outcome
17Adrenergic_beta2_Percent_InhibitionPercent Inhibition9Adrenergic_beta2Float%
18Adrenergic_beta2_OutcomeActive/Inactive9Outcome
19Transporter_Norepinephrine_(NET)_Percent_InhibitionPercent Inhibition10Transporter_Norepinephrine_(NET)Float%
20Transporter_Norepinephrine_(NET)_OutcomeActive/Inactive10Outcome
21Bradykinin_B1_Percent_InhibitionPercent Inhibition11Bradykinin_B1Float%
22Bradykinin_B1_OutcomeActive/Inactive11Outcome
23Bradykinin_B2_Percent_InhibitionPercent Inhibition12Bradykinin_B2Float%
24Bradykinin_B2_OutcomeActive/Inactive12Outcome
25Calcium_Channel_L-Type_Benzothiazepine_Percent_InhibitionPercent Inhibition13Calcium_Channel_L-Type_BenzothiazepineFloat%
26Calcium_Channel_L-Type_Benzothiazepine_OutcomeActive/Inactive13Outcome
27Calcium_Channel_L-Type_Dihydropyridine_Percent_InhibitionPercent Inhibition14Calcium_Channel_L-Type_DihydropyridineFloat%
28Calcium_Channel_L-Type_Dihydropyridine_OutcomeActive/Inactive14Outcome
29Calcium_Channel_N-Type_Percent_InhibitionPercent Inhibition15Calcium_Channel_N-TypeFloat%
30Calcium_Channel_N-Type_OutcomeActive/Inactive15Outcome
31Cannabinoid_CB1_Percent_InhibitionPercent Inhibition16Cannabinoid_CB1Float%
32Cannabinoid_CB1_OutcomeActive/Inactive16Outcome
33Dopamine_D1_Percent_InhibitionPercent Inhibition17Dopamine_D1Float%
34Dopamine_D1_OutcomeActive/Inactive17Outcome
35Dopamine_D2S_Percent_InhibitionPercent Inhibition18Dopamine_D2SFloat%
36Dopamine_D2S_OutcomeActive/Inactive18Outcome
37Dopamine_D3_Percent_InhibitionPercent Inhibition19Dopamine_D3Float%
38Dopamine_D3_OutcomeActive/Inactive19Outcome
39Dopamine_D4.2_Percent_InhibitionPercent Inhibition20Dopamine_D4.2Float%
40Dopamine_D4.2_OutcomeActive/Inactive20Outcome
41Transporter_Dopamine_(DAT)_Percent_InhibitionPercent Inhibition21Transporter_Dopamine_(DAT)Float%
42Transporter_Dopamine_(DAT)_OutcomeActive/Inactive21Outcome
43Endothelin_ETA_Percent_InhibitionPercent Inhibition22Endothelin_ETAFloat%
44Endothelin_ETA_OutcomeActive/Inactive22Outcome
45Endothelin_ETB_Percent_InhibitionPercent Inhibition23Endothelin_ETBFloat%
46Endothelin_ETB_OutcomeActive/Inactive23Outcome
47Epidermal_Growth Factor_(EGF)_Percent_InhibitionPercent Inhibition24Epidermal_Growth Factor_(EGF)Float%
48Epidermal_Growth Factor_(EGF)_OutcomeActive/Inactive24Outcome
49Estrogen_ERalpha_Percent_InhibitionPercent Inhibition25Estrogen_ERalphaFloat%
50Estrogen_ERalpha_OutcomeActive/Inactive25Outcome
51Transporter_GABA_Percent_InhibitionPercent Inhibition26Transporter_GABAFloat%
52Transporter_GABA_OutcomeActive/Inactive26Outcome
53GABAA_Muscimol_Central_Percent_InhibitionPercent Inhibition27GABAA_Muscimol_CentralFloat%
54GABAA_Muscimol_Central_OutcomeActive/Inactive27Outcome
55GABAB1A_Percent_InhibitionPercent Inhibition28GABAB1AFloat%
56GABAB1A_OutcomeActive/Inactive28Outcome
57Glucocorticoid_Percent_InhibitionPercent Inhibition29GlucocorticoidFloat%
58Glucocorticoid_OutcomeActive/Inactive29Outcome
59Glutamate_Kainate_Percent_InhibitionPercent Inhibition30Glutamate_KainateFloat%
60Glutamate_Kainate_OutcomeActive/Inactive30Outcome
61Glutamate_NMDA_Agonism_Percent_InhibitionPercent Inhibition31Glutamate_NMDA_AgonismFloat%
62Glutamate_NMDA_Agonism_OutcomeActive/Inactive31Outcome
63Histamine_H1_Percent_InhibitionPercent Inhibition32Histamine_H1Float%
64Histamine_H1_OutcomeActive/Inactive32Outcome
65Histamine_H2_Percent_InhibitionPercent Inhibition33Histamine_H2Float%
66Histamine_H2_OutcomeActive/Inactive33Outcome
67Histamine_H3_Percent_InhibitionPercent Inhibition34Histamine_H3Float%
68Histamine_H3_OutcomeActive/Inactive34Outcome
69Imidazoline_I2_Central_Percent_InhibitionPercent Inhibition35Imidazoline_I2_CentralFloat%
70Imidazoline_I2_Central_OutcomeActive/Inactive35Outcome
71Interleukin_IL-1_Percent_InhibitionPercent Inhibition36Interleukin_IL-1Float%
72Interleukin_IL-1_OutcomeActive/Inactive36Outcome
73Leukotriene_Cysteinyl_CysLT1_Percent_InhibitionPercent Inhibition37Leukotriene_Cysteinyl_CysLT1Float%
74Leukotriene_Cysteinyl_CysLT1_OutcomeActive/Inactive37Outcome
75Melatonin_MT1_Percent_InhibitionPercent Inhibition38Melatonin_MT1Float%
76Melatonin_MT1_OutcomeActive/Inactive38Outcome
77Muscarinic_M1_Percent_InhibitionPercent Inhibition39Muscarinic_M1Float%
78Muscarinic_M1_OutcomeActive/Inactive39Outcome
79Muscarinic_M2_Percent_InhibitionPercent Inhibition40Muscarinic_M2Float%
80Muscarinic_M2_OutcomeActive/Inactive40Outcome
81Muscarinic_M3_Percent_InhibitionPercent Inhibition41Muscarinic_M3Float%
82Muscarinic_M3_OutcomeActive/Inactive41Outcome
83Tachykinin_NK1_Percent_InhibitionPercent Inhibition42Tachykinin_NK1Float%
84Tachykinin_NK1_OutcomeActive/Inactive42Outcome
85Neuropeptide_YY1_Percent_InhibitionPercent Inhibition43Neuropeptide_YY1Float%
86Neuropeptide_YY1_OutcomeActive/Inactive43Outcome
87Neuropeptide_YY2_Percent_InhibitionPercent Inhibition44Neuropeptide_YY2Float%
88Neuropeptide_YY2_OutcomeActive/Inactive44Outcome
89Nicotinic_Acetylcholine_Percent_InhibitionPercent Inhibition45Nicotinic_AcetylcholineFloat%
90Nicotinic_Acetylcholine_OutcomeActive/Inactive45Outcome
91Nicotinic_Acetylcholine_Alpha1_Bungarotoxin_Percent_InhibitionPercent Inhibition46Nicotinic_Acetylcholine_Alpha1_BungarotoxinFloat%
92Nicotinic_Acetylcholine_Alpha1_Bungarotoxin_OutcomeActive/Inactive46Outcome
93Opiate_delta1 _(OP1, DOP)_Percent_InhibitionPercent Inhibition47Opiate_delta1 _(OP1, DOP)Float%
94Opiate_delta1 _(OP1, DOP)_OutcomeActive/Inactive47Outcome
95Opiate_kappa_(OP2, KOP)_Percent_InhibitionPercent Inhibition48Opiate_kappa_(OP2, KOP)Float%
96Opiate_kappa_(OP2, KOP)_OutcomeActive/Inactive48Outcome
97Opiate_mu_(OP3, MOP)_Percent_InhibitionPercent Inhibition49Opiate_mu_(OP3, MOP)Float%
98Opiate_mu_(OP3, MOP)_OutcomeActive/Inactive49Outcome
99Phorbol_Ester_Percent_InhibitionPercent Inhibition50Phorbol_EsterFloat%
100Phorbol_Ester_OutcomeActive/Inactive50Outcome
101Platelet_Activating_Factor _(PAF)_Percent_InhibitionPercent Inhibition51Platelet_Activating_Factor _(PAF)Float%
102Platelet_Activating_Factor _(PAF)_OutcomeActive/Inactive51Outcome
103Potassium_Channel_[KATP]_Percent_InhibitionPercent Inhibition52Potassium_Channel_[KATP]Float%
104Potassium_Channel_[KATP]_OutcomeActive/Inactive52Outcome
105Potassium_Channel_hERG_Percent_InhibitionPercent Inhibition53Potassium_Channel_hERGFloat%
106Potassium_Channel_hERG_OutcomeActive/Inactive53Outcome
107Prostanoid_EP4_Percent_InhibitionPercent Inhibition54Prostanoid_EP4Float%
108Prostanoid_EP4_OutcomeActive/Inactive54Outcome
109Purinergic_P2X_Percent_InhibitionPercent Inhibition55Purinergic_P2XFloat%
110Purinergic_P2X_OutcomeActive/Inactive55Outcome
111Purinergic_P2Y_Percent_InhibitionPercent Inhibition56Purinergic_P2YFloat%
112Purinergic_P2Y_OutcomeActive/Inactive56Outcome
113Rolipram_Percent_InhibitionPercent Inhibition57RolipramFloat%
114Rolipram_OutcomeActive/Inactive57Outcome
115Serotonin_(5-Hydroxytryptamine)_5-HT1A_Percent_InhibitionPercent Inhibition58Serotonin_(5-Hydroxytryptamine)_5-HT1AFloat%
116Serotonin_(5-Hydroxytryptamine)_5-HT1A_OutcomeActive/Inactive58Outcome
117Serotonin_(5-Hydroxytryptamine)_5-HT2B_Percent_InhibitionPercent Inhibition59Serotonin_(5-Hydroxytryptamine)_5-HT2BFloat%
118Serotonin_(5-Hydroxytryptamine)_5-HT2B_OutcomeActive/Inactive59Outcome
119Serotonin_(5-Hydroxytryptamine)_5-HT3_Percent_InhibitionPercent Inhibition60Serotonin_(5-Hydroxytryptamine)_5-HT3Float%
120Serotonin_(5-Hydroxytryptamine)_5-HT3_OutcomeActive/Inactive60Outcome
121Transporter_Serotonin_(5-Hydroxytryptamine)_(SERT)_Percent_InhibitionPercent Inhibition61Transporter_Serotonin_(5-Hydroxytryptamine)_(SERT)Float%
122Transporter_Serotonin_(5-Hydroxytryptamine)_(SERT)_OutcomeActive/Inactive61Outcome
123Sigma1_Percent_InhibitionPercent Inhibition62Sigma1Float%
124Sigma1_OutcomeActive/Inactive62Outcome
125Sodium _Channel_Site_2_Percent_InhibitionPercent Inhibition63Sodium _Channel_Site_2Float%
126Sodium _Channel_Site_2_OutcomeActive/Inactive63Outcome
127Androgen_(Testosterone)_AR_Percent_InhibitionPercent Inhibition64Androgen_(Testosterone)_ARFloat%
128Androgen_(Testosterone)_AR_OutcomeActive/Inactive64Outcome
129Thyroid_Hormone_Percent_InhibitionPercent Inhibition65Thyroid_HormoneFloat%
130Thyroid_Hormone_OutcomeActive/Inactive65Outcome
Additional Information
Grant Number: 5P50HL081009-03

Classification
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