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BioAssay: AID 650870

Agonist activity at rat EP4 receptor

To identify potent EP2/EP4 dual agonists with excellent subtype selectivity, a series of I(3)-lactam prostaglandin E analogs bearing a 16-phenyl I ..more
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 Tested Compounds
 Tested Compounds
All(8)
 
 
Active(8)
 
 
 Tested Substances
 Tested Substances
All(8)
 
 
Active(8)
 
 
AID: 650870
Data Source: ChEMBL (808318)
BioAssay Type: Confirmatory, Concentration-Response Relationship Observed
Depositor Category: Literature, Extracted
BioAssay Version:
Deposit Date: 2012-09-09
Modify Date: 2014-08-24

Data Table ( Complete ):           View Active Data    View All Data
Target
Sequence: RecName: Full=Prostaglandin E2 receptor EP4 subtype; Short=PGE receptor EP4 subtype; Short=PGE2 receptor EP4 subtype; AltName: Full=Prostanoid EP4 receptor
Description ..   
Comment ..   

Gene:PTGER4     Conserved Domain     Related Protein 3D Structures     More BioActivity Data..
BioActive Compounds: 8
Description:
Title: Discovery of novel prostaglandin analogs as potent and selective EP2/EP4 dual agonists.

Abstract: To identify potent EP2/EP4 dual agonists with excellent subtype selectivity, a series of I(3)-lactam prostaglandin E analogs bearing a 16-phenyl I
(PMID: 22386979)
Comment
Compounds with activity <= 50uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.
Categorized Comment - additional comments and annotations
From BioAssay Depositor:
Assay Type: Functional
Target Type: Target is a single protein chain
Assay Data Source: Scientific Literature
Result Definitions
TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1EC50*EC50 PubChem standard valueFloatμM
2EC50 activity commentEC50 activity commentString
3EC50 standard flagEC50 standard flagInteger
4EC50 qualifierEC50 qualifierString
5EC50 published valueEC50 published valueFloatnM
6EC50 standard valueEC50 standard valueFloatnM
7EC50 binding domainsEC50 binding domainsString

* Activity Concentration.

Data Table (Concise)
Data Table ( Complete ):     View Active Data    View All Data
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