Displacement of [3H]-PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting
To identify potent EP2/EP4 dual agonists with excellent subtype selectivity, a series of I(3)-lactam prostaglandin E analogs bearing a 16-phenyl I ..more
BioActive Compounds: 22
Title: Discovery of novel prostaglandin analogs as potent and selective EP2/EP4 dual agonists.
Abstract: To identify potent EP2/EP4 dual agonists with excellent subtype selectivity, a series of I(3)-lactam prostaglandin E analogs bearing a 16-phenyl I
Compounds with activity <= 50uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.
Assay Type: Binding
Assay Data Source: Scientific Literature
BAO: Assay Format: cell-based format
Assay Cell Type: CHO
Target Type: Target is a single protein chain
* Activity Concentration.
Data Table (Concise)