A novel class of 5-lipoxygenase (5-LO) inhibitors characterized by a central imidazo[1,2-a]pyridine scaffold, a cyclohexyl moiety and an aromatic system, is presented. This scaffold was identified in a virtual screening study and exhibits promising inhibitory potential on the 5-LO. Here, we investigate the structure-activity relationships of this compound class. With more ..
Target
| Sequence: RecName: Full=Arachidonate 5-lipoxygenase; Short=5-LO; Short=5-lipoxygenase Description ..   Protein Family: Lipoxygenase Comment .. Gene:ALOX5 Related Protein 3D Structures |
Tested Compound:
Description:
Title: SAR-study on a new class of imidazo[1,2-a]pyridine-based inhibitors of 5-lipoxygenase.
Abstract: A novel class of 5-lipoxygenase (5-LO) inhibitors characterized by a central imidazo[1,2-a]pyridine scaffold, a cyclohexyl moiety and an aromatic system, is presented. This scaffold was identified in a virtual screening study and exhibits promising inhibitory potential on the 5-LO. Here, we investigate the structure-activity relationships of this compound class. With N-cyclohexyl-6-methyl-2-(4-morpholinophenyl)imidazo[1,2-a]pyridine-3-amine (14), we identified a potent 5-LO inhibitor (IC(50)=0.16##M (intact cells) and 0.1##M (cell-free)), which may possess potential as an effective lead compound intervening with inflammatory diseases and certain types of cancer.
(PMID: 22326163)
Abstract: A novel class of 5-lipoxygenase (5-LO) inhibitors characterized by a central imidazo[1,2-a]pyridine scaffold, a cyclohexyl moiety and an aromatic system, is presented. This scaffold was identified in a virtual screening study and exhibits promising inhibitory potential on the 5-LO. Here, we investigate the structure-activity relationships of this compound class. With N-cyclohexyl-6-methyl-2-(4-morpholinophenyl)imidazo[1,2-a]pyridine-3-amine (14), we identified a potent 5-LO inhibitor (IC(50)=0.16##M (intact cells) and 0.1##M (cell-free)), which may possess potential as an effective lead compound intervening with inflammatory diseases and certain types of cancer.
(PMID: 22326163)
Categorized Comment
ChEMBL Assay Type: Binding
ChEMBL Assay Data Source: Scientific Literature
ChEMBL Target ID: 55
ChEMBL target type: Target is a single protein chain
ChEMBL Assay Data Source: Scientific Literature
ChEMBL Target ID: 55
ChEMBL target type: Target is a single protein chain
Result Definitions
| TID | Name | Description | Histogram | Type | Unit | |
|---|---|---|---|---|---|---|
| Outcome | The BioAssay activity outcome | Outcome | ||||
| 1 | Ratio IC50 activity comment | Ratio IC50 activity comment | String | |||
| 2 | Ratio IC50 standard flag | Ratio IC50 standard flag |  | Integer | ||
| 3 | Ratio IC50 qualifier | Ratio IC50 qualifier | String | |||
| 4 | Ratio IC50 published value | Ratio IC50 published value | | Float | ||
| 5 | Ratio IC50 standard value | Ratio IC50 standard value | | Float |
Data Table (Concise)
Classification
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