Bookmark and Share
BioAssay: AID 630820

Inhibition of CYP1A2

A series of pyrazole inhibitors of the human FPR1 receptor have been identified from high throughput screening. The compounds demonstrate potent inhibition in human neutrophils and attractive physicochemical and in vitro DMPK profiles to be of further interest. ..more
_
   
 Tested Compounds
 Tested Compounds
All(2)
 
 
Unspecified(2)
 
 
 Tested Substances
 Tested Substances
All(2)
 
 
Unspecified(2)
 
 
 Related BioAssays
 Related BioAssays
AID: 630820
Data Source: ChEMBL (788268)
Depositor Category: Literature, Extracted
BioAssay Version:
Deposit Date: 2012-09-09
Modify Date: 2013-11-17

Data Table ( Complete ):           All
Tested Compounds:
Description:
Title: Discovery of pyrazoles as novel FPR1 antagonists.

Abstract: A series of pyrazole inhibitors of the human FPR1 receptor have been identified from high throughput screening. The compounds demonstrate potent inhibition in human neutrophils and attractive physicochemical and in vitro DMPK profiles to be of further interest.
(PMID: 21955939)
Comment
Putative Target:

ChEMBL Target ID: 12594
Target Type: SINGLE PROTEIN
Pref Name: Cytochrome P450 1A2
Synonyms: CYPIA2;Cytochrome P(3)450;Cytochrome P450 1A2;Cytochrome P450 4;Cytochrome P450-P3;
Gene Name: CYP1A2;
Protein Accession: P05177;
Protein GI: 117144;
Organism: Homo sapiens
Tax ID: 9606
Target Classification: enzyme cytochrome p450 cyp_1 cyp_1a cyp_1a2
Confidence: Homologous single protein target assigned
Relationship Type: Homologous protein target assigned
Categorized Comment
ChEMBL Assay Type: ADMET

ChEMBL Assay Data Source: Scientific Literature

Result Definitions
TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1IC50*IC50 PubChem standard valueFloatμM
2IC50 activity commentIC50 activity commentString
3IC50 standard flagIC50 standard flagInteger
4IC50 qualifierIC50 qualifierString
5IC50 published valueIC50 published valueFloat
6IC50 standard valueIC50 standard valueFloatnM

* Activity Concentration.

Data Table (Concise)
PageFrom: