Fraction unbound in human - BioAssay Summary
A series of pyrazole inhibitors of the human FPR1 receptor have been identified from high throughput screening. The compounds demonstrate potent inhibition in human neutrophils and attractive physicochemical and in vitro DMPK profiles to be of further interest. ..more
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 Tested Compounds
 Tested Compounds
All(2)
 
 
Unspecified(2)
 
 
 Tested Substances
 Tested Substances
All(2)
 
 
Unspecified(2)
 
 
 Related BioAssays
 Related BioAssays
Table of Contents
AID: 630813
Data Source: ChEMBL (788261)
Depositor Category: Literature, Extracted
BioAssay Version:
Deposit Date: 2012-09-09
Modify Date: 2013-05-15

Data Table (Complete):           All
Tested Compounds:
Description:
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Title: Discovery of pyrazoles as novel FPR1 antagonists.

Abstract: A series of pyrazole inhibitors of the human FPR1 receptor have been identified from high throughput screening. The compounds demonstrate potent inhibition in human neutrophils and attractive physicochemical and in vitro DMPK profiles to be of further interest.
(PMID: 21955939)
Comment
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Putative Target:

ChEMBL Target ID: 50587
Target Type: ORGANISM
Pref Name: Homo sapiens
Organism: Homo sapiens
Tax ID: 9606
Confidence: Target assigned is non-molecular
Relationship Type: Non-molecular target assigned
Categorized Comment
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ChEMBL Assay Type: ADMET

ChEMBL Assay Data Source: Scientific Literature

Result Definitions
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TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1Funbound activity commentFunbound activity commentString
2Funbound standard flagFunbound standard flagInteger
3Funbound qualifierFunbound qualifierString
4Funbound published valueFunbound published valueFloat
5Funbound standard valueFunbound standard valueFloat

Data Table (Concise)
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