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BioAssay: AID 625273

DRUGMATRIX: Insulin radioligand binding (ligand: [125I] Insulin)

DRUGMATRIX: Insulin radioligand binding (ligand: [125I] Insulin) ..more
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 Tested Compounds
 Tested Compounds
All(838)
 
 
Unspecified(838)
 
 
 Tested Substances
 Tested Substances
All(869)
 
 
Active(1)
 
 
Unspecified(868)
 
 
 Related BioAssays
 Related BioAssays
AID: 625273
Data Source: ChEMBL (774771)
BioAssay Type: Confirmatory, Concentration-Response Relationship Observed
Depositor Category: Other
BioAssay Version:
Deposit Date: 2012-09-09
Modify Date: 2014-05-26

Data Table ( Complete ):           View Active Data    View All Data
Target
Sequence: RecName: Full=Insulin receptor; Short=IR; AltName: CD_antigen=CD220; Contains: RecName: Full=Insulin receptor subunit alpha; Contains: RecName: Full=Insulin receptor subunit beta; Flags: Precursor
Description ..   
Protein Family: Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
Comment ..   

Gene:INSR     Related Protein 3D Structures     More BioActivity Data..
Tested Compounds:
Description:
DRUGMATRIX: Insulin radioligand binding (ligand: [125I] Insulin)
Comment
Compounds with activity <= 50uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Categorized Comment
Assay Type: Binding

Assay Data Source: DrugMatrix in vitro pharmacology assays

Assay Test Type: In vitro

BAO: Assay Format: subcellular format

Assay Tissue: Liver

Assay Subcellular Fraction: membranes

Target Type: Target is a single protein chain

Result Definitions
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TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1IC50*IC50 PubChem standard valueFloatμM
2IC50 activity commentIC50 activity commentString
3IC50 standard flagIC50 standard flagInteger
4IC50 qualifierIC50 qualifierString
5IC50 published valueIC50 published valueFloatμM
6IC50 standard valueIC50 standard valueFloatnM
7IC50 binding domainsIC50 binding domainsString
8Ki activity commentKi activity commentString
9Ki standard flagKi standard flagInteger
10Ki qualifierKi qualifierString
11Ki published valueKi published valueFloatμM
12Ki standard valueKi standard valueFloatnM
13Ki binding domainsKi binding domainsString

* Activity Concentration.

Data Table (Concise)
Data Table ( Complete ):     View Active Data    View All Data
Classification
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