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BioAssay: AID 625271

DRUGMATRIX: HMG-CoA Reductase enzyme inhibition (substrate: [14C]HMG-CoA)

DRUGMATRIX: HMG-CoA Reductase enzyme inhibition (substrate: [14C]HMG-CoA) ..more
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 Tested Compounds
 Tested Compounds
All(839)
 
 
Active(9)
 
 
Unspecified(830)
 
 
 Tested Substances
 Tested Substances
All(869)
 
 
Active(9)
 
 
Unspecified(860)
 
 
 Related BioAssays
 Related BioAssays
AID: 625271
Data Source: ChEMBL (774769)
BioAssay Type: Confirmatory, Concentration-Response Relationship Observed
Depositor Category: Other
BioAssay Version:
Deposit Date: 2012-09-09
Modify Date: 2014-05-26

Data Table ( Complete ):           Active    All
Target
Sequence: RecName: Full=3-hydroxy-3-methylglutaryl-coenzyme A reductase; Short=HMG-CoA reductase
Description ..   
Protein Family: Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)
Comment ..   

Gene:HMGCR     Related Protein 3D Structures     More BioActivity Data..
BioActive Compounds: 9
Description:
DRUGMATRIX: HMG-CoA Reductase enzyme inhibition (substrate: [14C]HMG-CoA)
Comment
Compounds with activity <= 50uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Categorized Comment
Assay Type: Binding

Assay Data Source: DrugMatrix in vitro pharmacology assays

Assay Test Type: In vitro

BAO: Assay Format: biochemical format

Target Type: Target is a single protein chain

Protein Target Class: enzyme reductase

Result Definitions
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TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1IC50*IC50 PubChem standard valueFloatμM
3BEIBinding Efficiency Index(nM)Float
2SEISurface Efficiency Index(nM)Float
4LELigand EfficiencyFloat
5LLELipophilic Ligand EfficiencyFloat
6IC50 activity commentIC50 activity commentString
7IC50 standard flagIC50 standard flagInteger
8IC50 qualifierIC50 qualifierString
9IC50 published valueIC50 published valueFloatμM
10IC50 standard valueIC50 standard valueFloatnM
11Ki activity commentKi activity commentString
12Ki standard flagKi standard flagInteger
13Ki qualifierKi qualifierString
14Ki published valueKi published valueFloat
15Ki standard valueKi standard valueFloat

* Activity Concentration.

Data Table (Concise)
Classification
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