DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) - BioAssay Summary
DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) ..more
 _
   
 Tested Compounds
 Tested Compounds
All(857)
 
 
Active(48)
 
 
Unspecified(809)
 
 
 Tested Substances
 Tested Substances
All(870)
 
 
Active(50)
 
 
Unspecified(820)
 
 
 Related BioAssays
 Related BioAssays
Table of Contents
AID: 625247
Data Source: ChEMBL (774745)
Depositor Category: Other
BioAssay Version:
Deposit Date: 2012-09-09
Modify Date: 2013-05-15

Data Table (Complete):           Active    All
Target
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Sequence: RecName: Full=Cytochrome P450 2C19; AltName: Full=(R)-limonene 6-monooxygenase; AltName: Full=(S)-limonene 6-monooxygenase; AltName: Full=(S)-limonene 7-monooxygenase; AltName: Full=CYPIIC17; AltName: Full=CYPIIC19; AltName: Full=Cytochrome P450-11A; AltName: Full=Cytochrome P450-254C; AltName: Full=Mephenytoin 4-hydroxylase
Description ..   
Protein Family: Cytochrome P450
Comment ..   

Gene:CYP2C19     Related Protein 3D Structures
BioActive Compounds: 48
Description:
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DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)
Comment
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Compounds with activity <= 50uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.



Publication:
Journal: NULL
Year: NULL
Volume: NULL
Issue: NULL
First Page: NULL
Last Page: NULL
Categorized Comment
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ChEMBL Assay Type: Binding

ChEMBL Assay Data Source: DrugMatrix in vitro pharmacology assays

ChEMBL Assay Test Type: In vitro

ChEMBL Assay Cell Type: BTI-TN-5B1-4

ChEMBL Target ID: 12912

ChEMBL target type: Target is a single protein chain

Result Definitions
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TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1IC50*IC50 PubChem standard valueFloatμM
2BEIBinding Efficiency Index(nM)Float
3SEISurface Efficiency Index(nM)Float
4IC50 activity commentIC50 activity commentString
5IC50 standard flagIC50 standard flagInteger
6IC50 qualifierIC50 qualifierString
7IC50 published valueIC50 published valueFloatnM
8IC50 standard valueIC50 standard valueFloatnM
9IC50 binding domainsIC50 binding domainsString
10Ki activity commentKi activity commentString
11Ki standard flagKi standard flagInteger
12Ki qualifierKi qualifierString
13Ki published valueKi published valueFloat
14Ki standard valueKi standard valueFloat
15Ki binding domainsKi binding domainsString
* Activity Concentration.

Data Table (Concise)
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Classification
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