DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) - BioAssay Summary
DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) ..more
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 Tested Compounds
 Tested Compounds
All(857)
 
 
Active(45)
 
 
Unspecified(813)
 
 
 Tested Substances
 Tested Substances
All(870)
 
 
Active(45)
 
 
Unspecified(825)
 
 
 Related BioAssays
 Related BioAssays
Table of Contents
AID: 625243
Data Source: ChEMBL (774741)
Depositor Category: Other
BioAssay Version:
Deposit Date: 2012-09-09
Modify Date: 2013-05-15

Data Table (Complete):           Active    All
Target
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Sequence: RecName: Full=Prostaglandin G/H synthase 1; AltName: Full=Cyclooxygenase-1; Short=COX-1; AltName: Full=Prostaglandin H2 synthase 1; Short=PGH synthase 1; Short=PGHS-1; Short=PHS 1; AltName: Full=Prostaglandin-endoperoxide synthase 1; Flags: Precursor
Description ..   
Protein Family: Animal prostaglandin endoperoxide synthase and related bacterial proteins
Comment ..   

Gene:PTGS1     Related Protein 3D Structures
BioActive Compounds: 45
Description:
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DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid)
Comment
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Compounds with activity <= 50uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.



Publication:
Journal: NULL
Year: NULL
Volume: NULL
Issue: NULL
First Page: NULL
Last Page: NULL
Categorized Comment
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ChEMBL Assay Type: Binding

ChEMBL Assay Data Source: DrugMatrix in vitro pharmacology assays

ChEMBL Assay Test Type: In vitro

ChEMBL Assay Tissue: Platelets

ChEMBL Target ID: 96

ChEMBL target type: Target is a single protein chain

Result Definitions
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Show more
TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1IC50*IC50 PubChem standard valueFloatμM
2BEIBinding Efficiency Index(nM)Float
3SEISurface Efficiency Index(nM)Float
4IC50 activity commentIC50 activity commentString
5IC50 standard flagIC50 standard flagInteger
6IC50 qualifierIC50 qualifierString
7IC50 published valueIC50 published valueFloatnM
8IC50 standard valueIC50 standard valueFloatnM
9IC50 binding domainsIC50 binding domainsString
10Ki activity commentKi activity commentString
11Ki standard flagKi standard flagInteger
12Ki qualifierKi qualifierString
13Ki published valueKi published valueFloat
14Ki standard valueKi standard valueFloat
15Ki binding domainsKi binding domainsString
* Activity Concentration.

Data Table (Concise)
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Classification
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