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BioAssay: AID 625191

DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)

DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) ..more
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 Tested Compounds
 Tested Compounds
All(840)
 
 
Active(38)
 
 
Unspecified(802)
 
 
 Tested Substances
 Tested Substances
All(891)
 
 
Active(39)
 
 
Unspecified(852)
 
 
 Related BioAssays
 Related BioAssays
AID: 625191
Data Source: ChEMBL (774689)
Depositor Category: Other
BioAssay Version:
Deposit Date: 2012-09-09
Modify Date: 2013-11-17

Data Table ( Complete ):           Active    All
Target
Sequence: RecName: Full=5-hydroxytryptamine receptor 1B; Short=5-HT-1B; Short=5-HT1B; AltName: Full=Serotonin receptor 1B
Description ..   
Protein Family: Serpentine type 7TM GPCR chemoreceptor Srx
Comment ..   

Gene:HTR1B     Related Protein 3D Structures     More BioActivity Data..
BioActive Compounds: 38
Description:
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)
Comment
Compounds with activity <= 50uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Categorized Comment
ChEMBL Assay Type: Binding

ChEMBL Assay Data Source: DrugMatrix in vitro pharmacology assays

ChEMBL Assay Test Type: In vitro

ChEMBL Assay Tissue: Cerebral cortex

ChEMBL Assay Subcellular Fraction: membranes

ChEMBL Target ID: 10577

ChEMBL Target Type: Target is a single protein chain

Result Definitions
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TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1IC50*IC50 PubChem standard valueFloatμM
2IC50 activity commentIC50 activity commentString
3IC50 standard flagIC50 standard flagInteger
4IC50 qualifierIC50 qualifierString
5IC50 published valueIC50 published valueFloatμM
6IC50 standard valueIC50 standard valueFloatnM
7IC50 binding domainsIC50 binding domainsString
8IC50 Binding Efficiency Index(nM)IC50 Binding Efficiency Index(nM)Float
9IC50 Surface Efficiency Index(nM)IC50 Surface Efficiency Index(nM)Float
10IC50 Ligand EfficiencyIC50 Ligand EfficiencyFloat
11IC50 Lipophilic Ligand EfficiencyIC50 Lipophilic Ligand EfficiencyFloat
12Ki activity commentKi activity commentString
13Ki standard flagKi standard flagInteger
14Ki qualifierKi qualifierString
15Ki published valueKi published valueFloatμM
16Ki standard valueKi standard valueFloatnM
17Ki binding domainsKi binding domainsString
18Ki Binding Efficiency Index(nM)Ki Binding Efficiency Index(nM)Float
19Ki Surface Efficiency Index(nM)Ki Surface Efficiency Index(nM)Float
20Ki Ligand EfficiencyKi Ligand EfficiencyFloat
21Ki Lipophilic Ligand EfficiencyKi Lipophilic Ligand EfficiencyFloat

* Activity Concentration.

Data Table (Concise)
Classification
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