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BioAssay: AID 625190

DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT)

DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) ..more
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 Tested Compounds
 Tested Compounds
All(841)
 
 
Active(70)
 
 
Unspecified(771)
 
 
 Tested Substances
 Tested Substances
All(898)
 
 
Active(72)
 
 
Unspecified(826)
 
 
 Related BioAssays
 Related BioAssays
AID: 625190
Data Source: ChEMBL (774688)
BioAssay Type: Confirmatory, Concentration-Response Relationship Observed
Depositor Category: Other
BioAssay Version:
Deposit Date: 2012-09-09
Modify Date: 2014-08-25

Data Table ( Complete ):           View Active Data    View All Data
BioActive Compounds: 70
Description:
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT)
Comment
Compounds with activity <= 50uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Putative Target:

ChEMBL Target ID: 10576
Target Type: SINGLE PROTEIN
Pref Name: Serotonin 1a (5-HT1a) receptor
Synonyms: 5-HT-1A;5-HT1A;5-hydroxytryptamine receptor 1A;Serotonin receptor 1A;
Gene Name: 5ht1a;Htr1a;
Protein Accession: P19327;
Protein GI: 112812;
Organism: Rattus norvegicus
Tax ID: 10116
Target Classification: membrane receptor 7tm1 smallmol monoamine receptor serotonin receptor
Confidence: Homologous single protein target assigned
Relationship Type: Homologous protein target assigned
Categorized Comment - additional comments and annotations
From BioAssay Depositor:
Assay Type: Binding
Assay Data Source: DrugMatrix
Assay Cell Type: CHO-K1
Assay Test Type: In vitro
Assay Subcellular Fraction: membranes
Result Definitions
Show more
TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1IC50*IC50 PubChem standard valueFloatμM
2IC50 activity commentIC50 activity commentString
3IC50 standard flagIC50 standard flagInteger
4IC50 qualifierIC50 qualifierString
5IC50 published valueIC50 published valueFloatμM
6IC50 standard valueIC50 standard valueFloatnM
7IC50 Binding Efficiency Index(nM)IC50 Binding Efficiency Index(nM)Float
8IC50 Surface Efficiency Index(nM)IC50 Surface Efficiency Index(nM)Float
9IC50 Ligand EfficiencyIC50 Ligand EfficiencyFloat
10IC50 Lipophilic Ligand EfficiencyIC50 Lipophilic Ligand EfficiencyFloat
11Ki activity commentKi activity commentString
12Ki standard flagKi standard flagInteger
13Ki qualifierKi qualifierString
14Ki published valueKi published valueFloatμM
15Ki standard valueKi standard valueFloatnM
16Ki Binding Efficiency Index(nM)Ki Binding Efficiency Index(nM)Float
17Ki Surface Efficiency Index(nM)Ki Surface Efficiency Index(nM)Float
18Ki Ligand EfficiencyKi Ligand EfficiencyFloat
19Ki Lipophilic Ligand EfficiencyKi Lipophilic Ligand EfficiencyFloat

* Activity Concentration.

Data Table (Concise)
Data Table ( Complete ):     View Active Data    View All Data
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