DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) - BioAssay Summary
DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) ..more
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 Tested Compounds
 Tested Compounds
All(857)
 
 
Active(29)
 
 
Unspecified(828)
 
 
 Tested Substances
 Tested Substances
All(870)
 
 
Active(29)
 
 
Unspecified(841)
 
 
 Related BioAssays
 Related BioAssays
Table of Contents
AID: 625162
Data Source: ChEMBL (774660)
Depositor Category: Other
BioAssay Version:
Deposit Date: 2012-09-09
Modify Date: 2013-05-15

Data Table (Complete):           Active    All
Target
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Sequence: RecName: Full=Kappa-type opioid receptor; Short=K-OR-1; Short=KOR-1
Description ..   
Protein Family: Serpentine type 7TM GPCR chemoreceptor Srx
Comment ..   

Gene:OPRK1     Related Protein 3D Structures
BioActive Compounds: 29
Description:
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DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine)
Comment
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Compounds with activity <= 50uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.



Publication:
Journal: NULL
Year: NULL
Volume: NULL
Issue: NULL
First Page: NULL
Last Page: NULL
Categorized Comment
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ChEMBL Assay Type: Binding

ChEMBL Assay Data Source: DrugMatrix in vitro pharmacology assays

ChEMBL Assay Test Type: In vitro

ChEMBL Assay Cell Type: HEK293

ChEMBL Assay Subcellular Fraction: membranes

ChEMBL Target ID: 137

ChEMBL target type: Target is a single protein chain

Result Definitions
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TIDNameDescriptionHistogramTypeUnit
OutcomeThe BioAssay activity outcomeOutcome
1IC50*IC50 PubChem standard valueFloatμM
2IC50 activity commentIC50 activity commentString
3IC50 standard flagIC50 standard flagInteger
4IC50 qualifierIC50 qualifierString
5IC50 published valueIC50 published valueFloatnM
6IC50 standard valueIC50 standard valueFloatnM
7IC50 binding domainsIC50 binding domainsString
8IC50 Binding Efficiency Index(nM)IC50 Binding Efficiency Index(nM)Float
9Surface Efficiency Index(nM)Surface Efficiency Index(nM)Float
10Ki activity commentKi activity commentString
11Ki standard flagKi standard flagInteger
12Ki qualifierKi qualifierString
13Ki published valueKi published valueFloatnM
14Ki standard valueKi standard valueFloatnM
15Ki binding domainsKi binding domainsString
16Ki Binding Efficiency Index(nM)Ki Binding Efficiency Index(nM)Float
17Surface Efficiency Index(nM)Surface Efficiency Index(nM)Float
* Activity Concentration.

Data Table (Concise)
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Classification
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